30750-74-4

Basic information

• Product Name: Boc-L-Aspartic anhydride
• Synonyms: Boc-L-Aspartic anhydride;N-[(3S)-Tetrahydro-2,5-dioxo-3-furanyl]-carbamic acid 1,1-dimethylethyl ester;N-tert-Butoxycarbonyl-L-aspartic anhydride;(S)-tert-Butyl (2,5-dioxotetrahydrofuran-3-yl)carbamate;tert-butyl N-[(3S)-2,5-dioxooxolan-3-yl]carbamate
• CAS NO: 30750-74-4
• Molecular Formula: C₉H₁₃NO₅
• Molecular Weight: 215.20322
• Mol File: 30750-74-4.mol
• Article Data: 10

Chemical Properties

• Melting Point: 134-135℃ (acetone ligroine )
• Boiling Point: 387.3±31.0 °C(Predicted)
• Appearance: /
• Density: 1.25±0.1 g/cm3 (20 ºC 760 Torr)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 10.14±0.20(Predicted)
• CAS DataBase Reference: Boc-L-Aspartic anhydride(CAS DataBase Reference)
• NIST Chemistry Reference: Boc-L-Aspartic anhydride(30750-74-4)
• EPA Substance Registry System: Boc-L-Aspartic anhydride(30750-74-4)

Safety Data

• Hazardous Substances Data: 30750-74-4(Hazardous Substances Data)

Usage

General Description

Boc-L-Aspartic anhydride is a chemical compound used in organic synthesis as a reagent for the protection of amino groups. It is a derivative of aspartic acid, containing a Boc (tert-butoxycarbonyl) protecting group on the α-amino group. Boc-L-Aspartic anhydride is commonly utilized in peptide synthesis to protect the aspartic acid residue and prevent unwanted side reactions during the assembly of peptide chains. Boc-L-Aspartic anhydride is a versatile reagent that enables efficient and selective protection of the aspartic acid residue in peptide and protein synthesis.

Upstream product

• 13726-67-5 Boc-Asp-OH 
• 56-84-8 L-Aspartic acid 
• 24424-99-5 di-tert-butyl dicarbonate 
• 693-13-0 diisopropyl-carbodiimide 

Downstream Products

• 1360817-30-6 C₃₀H₂₉FN₄O₅S 
• 1360817-31-7 C₃₀H₂₉FN₄O₅S 
• 40856-59-5 tert-butyl (3S)-2-oxotetrahydrofuran-3-ylcarbamate 
• 104227-71-6 N-[(3S)-tetrahydro-5-oxo-3-furanyl]carbamic acid-1,1-dimethylethyl ester 
• 117752-82-6 (S)-β-amino-γ-butyrolactone hydrochloride 
• 130052-03-8 2-tert-butoxycarbonylamino-succinic acid 4-benzyl ester 1-(2-cyano-ethyl) ester 
• 130052-02-7 Boc-Asp(OChx)-OCet 
• 73821-95-1 Boc-Asp(O-cyclohexyl)-OH 
• 1676-90-0 Boc-Asp(OtBu)-OH 
• 7536-58-5 BOC-L-aspartic acid 4-benzyl ester 
• 83345-44-2 3-tert-butoxycarbonylamino-4-hydroxy-butyric acid 
• 221106-60-1 (S)-3-(tert-butoxycarbonylamino)-4-(tert-butyldimethylsiloxy)butyric acid benzyl ester 
• 129046-87-3 fluoren-9-ylmethyl N-tert-butyloxycarbonyl-L-aspartate 
• 56-84-8 L-Aspartic acid 

Relevant articles and documents

CRYSTALLINE FORMS OF A PYRROLIDONE DERIVATIVE USEFUL IN THE TREATMENT OF ALZHEIMER'S DISEASE AND PREPARATION THEREOF

The present invention provides processes to manufacture crystalline N-[(3S)-1-[4-[(3-fluorophenyl)methoxy]phenyl]-5-oxo-pyrrolidin-3-yl]acetamide. Also disclosed are polymorphic forms of said compound as well as compounds useful as intermediates in the methods of the invention.

Isoform-selective thiazolo[5,4-b]pyridine S1P1 agonists possessing acyclic amino carboxylate head-groups

Replacement of the azetidine carboxylate of an S1P1 agonist development candidate, AMG 369, with a range of acyclic head-groups led to the identification of a novel, S1P3-sparing S1P1 agonist, (-)-2-amino -4-(3-fluoro-4-(5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridin-2-yl) phenyl)-2-methylbutanoic acid (8c), which possessed good in vivo efficacy and pharmacokinetic properties. A 0.3 mg/kg oral dose of 8c produced a statistically significant reduction in blood lymphocyte counts 24 h post-dosing in female Lewis rats.

An unexpected product from attempted reductive etherification of a silyl alcohol with an aldehyde

Reductive etherification, using BiBr3/Et3SiH, between two modified amino acids, one with a silyl alcohol side chain and one with an aldehyde side chain, gave, not the desired bis-amino acid, but a tetrahydrooxazine, in good yield.