30764-27-3Relevant academic research and scientific papers
15N NMR Spectroscopy. 28 - Solvent Effects on the 15N - 13C Coupling Constants of Amides, Imides, Ureas and Polypeptides
Kricheldorf, Hans R.
, p. 455 - 461 (1980)
The 15N - 13C coupling constants of 15N-enriched acetamide, N-acetylglycine anilide, phthalimide, α,α'-bisphthalimido-p-xylene, N-methyl-N'-phenylurea, poly-L-alanine, poly-L-leucine and poly-L-valine were measured in various solvents.It was found that th
The Ugly Duckling Metamorphosis: The Ammonia/Formaldehyde Couple Made Possible in Ugi Reactions.
Rosalba, Thaissa Pasquali F.,Kas, Samia Sayegh A.,Sampaio, Ana Beatriz S.,Salvador, Carlos Eduardo M.,Andrade, Carlos Kleber Z.
, p. 2831 - 2842 (2021/05/13)
Ugi reactions are still a challenge when the concomitant use of ammonia and formaldehyde is required. Herein, we propose a strategy to overcome this challenge using hexamethylenetetramine (HMTA) as a singular key for the employment of these two simple starting materials in the Ugi reaction. Acylaminoacetamide derivatives were prepared in good to excellent yields by this new methodology. The scope and optimization of the reaction conditions were investigated. This novel methodology was successfully applied in the synthesis of two different diketopiperazines (DKPs) using the Ugi/Deprotection+Activation/Cyclization (UDAC) method. A continuous flow approach was also used in this methodology.
Synthesis and characterization of low molecular weight organogelators derived from amide derivatives of N-acetylglycine
Ali, Firdous Imran,Shaikh, Rabel,Bari, Ahmed,Khan, Umair Ahmad,Muhammad, Shoaib,Hashmi, Imran Ali
, p. 99 - 104 (2019/05/01)
Summary: Six new N-acetylglycine amides and bisamides were prepared by reacting N-acetylglycine with different isocyanates including, hexamethylene diisocyanate, bis(4isocyanatophenyl)methane, toluene 2,4-diisocyanate, 1,3-bis(2-isocyanatopropan-2-yl)benzene, phenyl isocyanate and 2-naphthyl isocyanate to furnish amides 1-6. The gelation ability of compounds (1-6) was investigated using fourteen different solvents including polar, non-polar organic solvents. Only compound 1 solidified toluene. Characterization of compounds (1-6) was done using spectroscopic methods, ESI-MS, FTIR, 1H- and 13C-NMR. The morphology of toluene organogel (as xerogel) was determined through scanning electron microscopy (SEM).
A study of fragmentation of protonated amides of some acylated amino acids by tandem mass spectrometry: Observation of an unusual nitrilium ion
Talaty, Erach R.,Young, Sarah M.,Dain, Ryan P.,Van Stipdonk, Michael J.
experimental part, p. 1119 - 1129 (2012/03/26)
A tandem mass spectrometric study of a series of secondary amides of acetylglycine and hippuric acid utilizing electrospray ionization (ESI) was conducted. Among the fragment ions observed was an unusual one, which we have determined to be a nitrilium ion
A novel one flask synthesis of 1,2-substituted 5-imidazolones
Dasgupta, Purbasha,Taunk, Archana
scheme or table, p. 1242 - 1245 (2010/08/19)
One flask synthesis of 4-arylmethylene-1-phenyl-2-styryl-2-imidazolin-5- ones was achieved by the phenyl isothiocyanate-mediated condensation of N-acetyl glycine with aromatic aldehydes.
Reaction of Phenyl Isothiocyanate with Some α,N-Acylamino and Dicarboxylic Acids
Ashare, Ram,Ram, Ram N.,Mukerjee, Arya K.
, p. 759 - 760 (2007/10/02)
Dianilides are obtained in the reaction of phenyl isothiocyanate with dicarboxylic acids, such as oxalic, malonic, glutaric and adipic acids, and not in the case of succinic and phthalic acids.In the case of succinic acid, the product is monoanilide, dianilide or N-phenylsuccinimide, depending upon the reaction conditions.Phthalic acid always gives N-phenylphthalimide.N-Acylamino acids on reaction with phenyl isothiocyanate yield the corresponding anilides.The probable mechanisms of this reaction are discussed.
