312-32-3

Usage

Uses

Used in Pharmaceutical Synthesis:
1-(4-Fluorophenylsulfonyl)piperidine is utilized as an intermediate in the synthesis of various pharmaceuticals, leveraging its unique structure to facilitate the creation of novel compounds with potential therapeutic benefits.
Used in Medicinal Chemistry:
In the realm of medicinal chemistry, 1-(4-Fluorophenylsulfonyl)piperidine is employed as a valuable building block. Its distinctive properties enable the development of new drugs with the aim of addressing unmet medical needs.
Used in Organic Synthesis:
1-(4-Fluorophenylsulfonyl)piperidine is also used as a reagent and catalyst in organic synthesis. Its application in this field is geared towards enhancing the efficiency and selectivity of chemical reactions, thereby contributing to the advancement of organic chemistry methodologies.
Used in Drug Discovery and Development:
1-(4-Fluorophenylsulfonyl)piperidine plays a significant role in drug discovery and development, serving as a key component in the design and synthesis of new drug candidates. Its contribution to this field is underscored by its ability to expand the scope of available chemical entities for therapeutic intervention.

Upstream product

• 110-89-4 piperidine 
• 349-88-2 4-Fluorobenzenesulfonyl chloride 
• 873-55-2 sodium benzenesulfonate 
• 6462-50-6 sodium 4-methoxybenzenesulfinate 
• 824-80-6 sodium 4-fluorobenzenesulfinate 
• 66003-76-7 Diphenyliodonium triflate 
• 591-50-4 iodobenzene 
• 71-43-2 benzene 
• 696-62-8 para-iodoanisole 
• 5720-07-0 4-methoxyphenylboronic acid 
• 1765-93-1 4-fluoroboronic acid 
• 332-01-4 1-((4-fluorophenyl)diazenyl)piperidine 
• 371-40-4 4-fluoroaniline 
• 861359-74-2 diisopropylethyl amine 

Relevant academic research and scientific papers

Iron-catalyzed synthesis of arylsulfinates through radical coupling reaction

A novel strategy for installation of a sulfonyl fragment into arenes has been accomplished via an iron-catalyzed radical coupling reaction. Arene radicals derived from diaryliodoniums via single electron transfer reaction combine with sulfoxylate anion radicals readily generated from commercially available rongalite (HOCH2SO2Na·2H2O) to afford arylsulfinates efficiently at room temperature. In this protocol, a broad range of functional groups are tolerated to give products in good yields.

Catalytic conversion of aryl triazenes into aryl sulfonamides using sulfur dioxide as the sulfonyl source

Various sulfonamides have been synthesized from triazenes and sulfur dioxide. In the presence of just a catalytic amount of BF3· OEt2, a series of 1-aryl-triazenes were converted into sulfonyl hydrazines in good to excellent yields. When using CuCl2 as the catalyst, the corresponding sulfonamides can be produced from the 1-aryl triazenes in good yields. This journal is the Partner Organisations 2014.

Substituted 2- (S) -hydroxy-3- (piperidin-4-yl-methylamino) -propyl ethers and substituted 2-aryl-2- (R) - hydroxy-1- (piperidin-4-yl-methyl) -ethylamine beta-3 adrenergic receptor agonists

This invention provides compounds of Formula I having the structure wherein A, B, Z, R and R1 are as defined hereinbefore, or a pharmaceutically acceptable salt thereof, which are useful in treating or inhibiting metabolic disorders related to insulin resistance or hyperglycemia (typically associated with obesity or glucose intolerance), atherosclerosis, gastrointestinal disorders, neurogenetic inflammation, glaucoma, ocular hypertension and frequent urination; and are particularly useful in the treatment or inhibition of type II diabetes.

HETEROCYCLIC BETA-3 ADRENERGIC RECEPTOR AGONISTS

This invention provides compounds of Formula I having the structure U, V, W, X, and Y are as defined hereinbefore, or a pharmaceutically acceptable salt thereof, which are useful in treating or inhibiting metabolic disorders related to insulin resistance or hyperglycemia (typically associated with obesity or glucose intolerance), atherosclerosis, gastrointestinal disorders, neurogenetic inflammation, glaucoma, ocular hypertension and frequent urination; and are particularly useful in the treatment or inhibition of type II diabetes.