3128-05-0

Basic information

• Product Name: 2-(3-oxocyclopentyl)acetic acid
• Synonyms: 2-(3-oxocyclopentyl)acetic acid;3-Oxo-cyclopentaneacetic acid
• CAS NO: 3128-05-0
• Molecular Formula: C₇H₁₀O₃
• Molecular Weight: 142.1525
• Mol File: 3128-05-0.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 316.5°Cat760mmHg
• Flash Point: 159.5°C
• Appearance: /
• Density: 1.21g/cm³
• Vapor Pressure: 8.69E-05mmHg at 25°C
• Refractive Index: 1.492
• PKA: 4.52±0.10(Predicted)
• CAS DataBase Reference: 2-(3-oxocyclopentyl)acetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3-oxocyclopentyl)acetic acid(3128-05-0)
• EPA Substance Registry System: 2-(3-oxocyclopentyl)acetic acid(3128-05-0)

Safety Data

• Hazardous Substances Data: 3128-05-0(Hazardous Substances Data)

Usage

Uses

2-(3-Oxocyclopentyl)acetic Acid can be used as HIV integrase inhibitors.

InChI:InChI=1/C7H10O3/c8-6-2-1-5(3-6)4-7(9)10/h5H,1-4H2,(H,9,10)

Upstream product

• 92731-03-8 ethyl 2,4-dicarbethoxy-3-oxocyclopentylacetate 
• 91766-21-1 3-di(ethoxycarbonyl)methyl-1-cyclopentanone 
• 102539-66-2 (3-hydroxycyclopentyl)acetic acid 
• 1609185-27-4 tert-butyl-(3-hydroxycyclopentyl)acetate 
• 57042-08-7 Diethyl trans-hex-3-enedioate 
• 679836-06-7 2,4-dimethylpent-3-yl 2-(trimethylsilanyl)-2-(3-oxocyclopentyl)acetate 
• 930-30-3 cyclopent-2-enone 
• 7664-93-9 sulfuric acid 
• 7647-01-0 hydrogenchloride 
• 996-82-7 sodium diethylmalonate 
• 57020-97-0 ethyl 5-oxocyclopent-1-en-1-carboxylate 
• 74786-02-0 1-(tert-butyldimethylsilyloxy)-1-tert-butoxyethylene 
• 497-38-1 Norbornan-2-on 

Downstream Products

• 34130-51-3 methylester of 3-oxo-cyclopentylacetic acid 
• 347184-27-4 N-(3,4,5-Trimethoxyphenyl)-2-(3-oxocyclopentyl)acetamide 
• 1059063-13-6 C₁₃H₁₀ClFN₂O₂ 
• 66972-67-6 3-formylmethylcyclopentan-1-one 
• 84211-58-5 3-Oxo-4-(3-oxo-cyclopentyl)-N-phenyl-2-(triphenyl-λ⁵-phosphanylidene)-butyramide 
• 66972-66-5 3-Ketocyclopentylacetylchlorid 

Relevant articles and documents

Enantioselective Michael-Mukaiyama Additions of Silylketene acetals to 2-Carboxycyclopentenones Promoted by Chiral Ti Complexes.

The conjugate addition of t-butylpropionate silylketeneacetal 2 to 2-carboxycyclopentenones 3a-b promoted by TADDOL-derived Ti chlorides gives the ketoacid 6 with excellent d.e. and e.e. up to 47percent.

Anodic Oxidation of Norcamphor in Aqueous Electrolytes

Norcamphor (1) was anodically oxidized at Pb/PbO2 anodes in 1 M*H2SO4, MeCN/H2O (V/V = 1/1). 3-Oxocyclopentaneacetic acid (3) and oxabicyclooctan-3-one (4) were obtained with material yields up to 76percent and 42percent, respectively.The effects of electrode materials, current densities and concentrations were studied.A possible anodic oxidation mechanism was proposed.

Heterogeneous platinum catalytic aerobic oxidation of cyclopentane-1,2- diols to cyclopentane-1,2-diones

A method for the aerobic oxidation of cyclopentane-1,2-diols to the corresponding diketones over a commercial heterogeneous Pt/C catalyst is described. Unsubstituted and 3- or 4-substituted cyclopentane-1,2-diols are oxidized to 1,2-dicarbonyl compounds in good yields under the reported optimized reaction conditions (atmospheric air, 1 mol % of catalyst, 1 equiv of LiOH, aqueous solvents and 60 °C temperature). The method is applicable for producing cyclopentane-1,2-diketones in a scalable manner.