3137-83-5 Usage
Uses
Used in Chemical Synthesis:
3'-Isothiocyanatoacetanilide is used as a reagent in chemical synthesis for its ability to form stable thiourea linkages with amine groups. This property makes ITC-A a valuable tool in the modification and labeling of biomolecules for various applications in biochemistry and molecular biology.
Used in Bioconjugation Reactions:
In bioconjugation reactions, 3'-Isothiocyanatoacetanilide is used as a coupling agent to link biomolecules, such as proteins or nucleic acids, to other molecules or surfaces. The reactive isothiocyanate moiety of ITC-A allows for the formation of stable thiourea linkages, facilitating the attachment of biomolecules for research purposes.
Used in Pharmaceutical Research:
3'-Isothiocyanatoacetanilide is used as a potential anti-cancer agent in pharmaceutical research. Studies have shown that isothiocyanates, including ITC-A, exhibit anti-tumor effects in various cell lines and animal models. This makes ITC-A a promising candidate for the development of new cancer therapies.
Used in Biochemistry and Molecular Biology Research:
In biochemistry and molecular biology research, 3'-Isothiocyanatoacetanilide is used for the modification and labeling of biomolecules. The reactive isothiocyanate group of ITC-A enables the formation of stable thiourea linkages, allowing researchers to study the structure, function, and interactions of biomolecules more effectively.
Overall, 3'-Isothiocyanatoacetanilide is a versatile chemical compound with a wide range of applications in chemical synthesis, bioconjugation, pharmaceutical research, and biochemistry and molecular biology. Its unique properties, such as the ability to form stable thiourea linkages with amine groups and its potential anti-cancer properties, make ITC-A a valuable tool in various scientific and industrial fields.
Check Digit Verification of cas no
The CAS Registry Mumber 3137-83-5 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 3,1,3 and 7 respectively; the second part has 2 digits, 8 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 3137-83:
(6*3)+(5*1)+(4*3)+(3*7)+(2*8)+(1*3)=75
75 % 10 = 5
So 3137-83-5 is a valid CAS Registry Number.
InChI:InChI=1/C9H8N2OS/c1-7(12)11-9-4-2-3-8(5-9)10-6-13/h2-5H,1H3,(H,11,12)
3137-83-5Relevant academic research and scientific papers
Synthesis and in-vitro evaluation of 2-amino-4-arylthiazole as inhibitor of 3D polymerase against foot-and-mouth disease (FMD)
Jeong, Kwi-Wan,Lee, Jung-Hun,Park, Sun-Mi,Choi, Joo-Hyung,Jeong, Dae-Youn,Choi, Dong-Hwa,Nam, Yeonju,Park, Jong-Hyeon,Lee, Kwang-Nyeong,Kim, Su-Mi,Ku, Jin-Mo
, p. 387 - 397 (2015/09/01)
Foot-and-mouth disease (FMD) is a highly contagious vesicular disease of livestock caused by a highly variable RNA virus, foot-and-mouth disease virus (FMDV). One of the targets to suppress expansion of and to control FMD is 3D polymerase (FMDV 3Dpol). In this study, 2-amino-4-arylthiazole derivatives were synthesized and evaluated for their inhibitory activity against FMDV 3Dpol. Among them, compound 20i exhibited the most potent functional inhibition (IC50 = 0.39μM) of FMDV 3D polymerase and compound 24a (EC50=13.09 μM) showed more potent antiviral activity than ribavirin (EC50=1367 μM) and T1105 (EC50=347 μM) with IBRS-2 cells infected by the FMDV O/SKR/2010 strain.
