31519-22-9

Hazards Identification

Pictogram(s):

Signal:

Warning

GHS Hazard Statements:

H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
H335 (97.56%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statement Codes:

P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories:

Skin Irrit. 2 (100%)
Eye Irrit. 2 (100%)
STOT SE 3 (97.56%)

Usage

Uses

Used in Pharmaceutical Industry:
1,4-Dihydroxy-2-naphthoic acid is used as a therapeutic agent for the treatment of psoriasis. It has demonstrated potential in promoting the proliferation of Bifidobacterium, which can contribute to the modulation of the skin microbiome and provide relief from psoriasis symptoms.
Used in Probiotic Applications:
In the field of probiotics, 1,4-Dihydroxy-2-naphthoic acid is used as a growth promoter for Bifidobacterium species. This application is particularly relevant in the development of probiotic products aimed at improving gut health and overall well-being. By enhancing the growth of beneficial bacteria, 1,4-Dihydroxy-2-naphthoic acid can contribute to a balanced gut microbiota, which is essential for maintaining a healthy immune system and preventing various health issues.

InChI:InChI=1/C11H8O4/c12-9-5-8(11(14)15)10(13)7-4-2-1-3-6(7)9/h1-5,12-13H,(H,14,15)

Upstream product

• 59883-07-7 Diethyl 1,4-dihydroxynaphthalene-2,3-dicarboxylate 
• 86-48-6 1-hydroxy-2-naphthoic acid 
• 124-38-9 carbon dioxide 
• 84-66-2 Diethyl phthalate 
• 90-15-3 α-naphthol 
• 571-60-8 1,4-Dihydroxynaphthalene 
• 13588-28-8 di(propylene glycol) monomethyl ether 
• 623-11-0 1-methyl-4-nitrosobenzene 
• 97226-61-4 C₃₂H₄₄N₇O₂₀P₃S 

Downstream Products

• 1010-60-2 2-chloro-1,4-naphthoquinone 
• 5697-00-7 1,4-diacetoxynaphthalene 
• 856075-00-8 4-acetoxy-1-hydroxy-[2]naphthoic acid 
• 93325-42-9 1,4-Naphthohydrochinon-2-carboxanilid 
• 950191-89-6 C₁₈H₉F₅O₄ 
• 573-13-7 lapachenole 
• 1452153-45-5 methyl 5-hydroxy-2-methyl-2-phenyl-2,3-dihydronaphtho[1,2-b]furan-4-carboxylate 
• 1452153-47-7 methyl 5-hydroxy-2-(4-methoxyphenyl)-2,3-dihydronaphtho[ 1,2-b]furan-4-carboxylate 
• 61658-41-1 furomollugin 
• 54978-55-1 phenyl 1,4-dihydroxynaphthalene-2-carboxylate 

Relevant academic research and scientific papers

Synthesis, Conformation, and Complexation Behavior of 2,9,18,25-Tetraoxa(1,4)naphthalenophane

The synthesis of the title compound is described.Evidence is presented for its preferential "face-edge" conformation.Charge-transfer complexation proves to be a classical ?-? interaction with the "face-edge"conformation.There is no evidence for inclusion complexation.Attempted synthesis of substituted analogues of the title compound is described, including novel transformations in the 1,2,4-trisubstituted and 1,2,3,4-tetrasubstituted naphthalene series.

Method for producing 1,4-dihydroxy-2-naphthoic acid

A method for producing 1,4-dihydroxy-2-naphthoic acid which comprises the steps of: subjecting 1,4-dihydroxynaphthalene into an alkali metal salt formation reaction in an organic medium capable of dissolving 1,4-dihydroxynaphthalene using an alkali metal alcoholate; and subjecting the salt formation reaction mixture to carboxylation using carbon dioxide gas.

SYNTHESIS AND REVISED STRUCTURE OF THE O-SUCCINYLBENZOIC ACID COENZYME A ESTER, AN INTERMEDIATE IN MENAQUINONE BIOSYNTHESIS

Synthesis of the two isomers 2, 3 of the mono coenzyme A ester of o-succinylbenzoic acid (1, OSB, i.e. 4-(2-carboxyphenyl)-4-oxobutanoic acid) and enzymic conversion of 3 to 1,4-dihydroxy-2-naphtoic acid 7 shows that as opposed to previous assumptions the "aliphatic" rather than the"aromatic" carboxyl group in o-succinylbenzoic acid 1 is activated during vitamin K2 biosynthesis in Escherichia coli and Myobacterium phlei.