31519-22-9

Basic information

• Product Name: 1,4-Dihydroxy-2-naphthoic acid
• Synonyms: 1,4-DIHYDROXY-2-NAPHTHALENECARBOXYLIC ACID;1,4-DIHYDROXY-2-NAPHTHALIC ACID;1,4-DIHYDROXY-2-NAPHTHOIC ACID;1,4-dihydroxy-2-naphthalenecarboxylicaci;1,4-Dihydroxy-2-naphtoic acid;1,4-Dohydroxy-2-naphthoic acid;1,4-dihydroxy-2-naphthoate;1 4-DIHYDROXY-2-NAPHTHOIC ACID 98%
• CAS NO: 31519-22-9
• Molecular Formula: C₁₁H₈O₄
• Molecular Weight: 204.18
• EINECS: 250-674-7
• Product Categories: Intermediates of Dyes and Pigments;Naphthalene derivatives;C11 to C12;Carbonyl Compounds;Carboxylic Acids
• Mol File: 31519-22-9.mol
• Article Data: 3

Chemical Properties

• Melting Point: 220 °C (dec.)(lit.)
• Boiling Point: 461.7 °C at 760 mmHg
• Flash Point: 247.1 °C
• Appearance: /
• Density: 1.535 g/cm³
• Vapor Pressure: 2.55E-09mmHg at 25°C
• Refractive Index: 1.761
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 2.89±0.30(Predicted)
• Water Solubility: Slightly soluble in water.
• CAS DataBase Reference: 1,4-Dihydroxy-2-naphthoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 1,4-Dihydroxy-2-naphthoic acid(31519-22-9)
• EPA Substance Registry System: 1,4-Dihydroxy-2-naphthoic acid(31519-22-9)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39
• WGK Germany: 3
• TSCA: Yes
• Hazardous Substances Data: 31519-22-9(Hazardous Substances Data)

Usage

Chemical Properties

Lighte yellow powder

Uses

1,4-Dihydroxy-2-naphthoic acid from Propionibacterium freudenreichii is known to promote the proliferation of Bifidobacterium. It has potential therapeutic application for psoriasis treatment.

Definition

ChEBI: A naphthoic acid that is 2-naphthoic acid substituted by hydroxy groups at positions 1 and 4.

General Description

1,4-Dihydroxy-2-naphthoic acid from Propionibacterium freudenreichii is known to promote the proliferation of Bifidobacterium. It has potential therapeutic application for psoriasis treatment.

InChI:InChI=1/C11H8O4/c12-9-5-8(11(14)15)10(13)7-4-2-1-3-6(7)9/h1-5,12-13H,(H,14,15)

Upstream product

• 86-48-6 1-hydroxy-2-naphthoic acid 
• 90-15-3 α-naphthol 
• 571-60-8 1,4-Dihydroxynaphthalene 
• 13588-28-8 di(propylene glycol) monomethyl ether 
• 84-66-2 Diethyl phthalate 
• 623-11-0 1-methyl-4-nitrosobenzene 
• 59883-07-7 Diethyl 1,4-dihydroxynaphthalene-2,3-dicarboxylate 
• 124-38-9 carbon dioxide 
• 97226-61-4 C₃₂H₄₄N₇O₂₀P₃S 

Downstream Products

• 856075-00-8 4-acetoxy-1-hydroxy-[2]naphthoic acid 
• 78265-13-1 1,4-dimethoxynaphthalene-2-carboxylic acid 
• 950191-89-6 C₁₈H₉F₅O₄ 
• 1010-60-2 2-chloro-1,4-naphthoquinone 
• 93325-42-9 1,4-Naphthohydrochinon-2-carboxanilid 
• 5697-00-7 1,4-diacetoxynaphthalene 
• 173043-38-4 2-amino-3-carboxy-1,4-naphthoquinone 
• 54978-55-1 phenyl 1,4-dihydroxynaphthalene-2-carboxylate 

Relevant articles and documents

-

-

Method for producing 1,4-dihydroxy-2-naphthoic acid

A method for producing 1,4-dihydroxy-2-naphthoic acid which comprises the steps of: subjecting 1,4-dihydroxynaphthalene into an alkali metal salt formation reaction in an organic medium capable of dissolving 1,4-dihydroxynaphthalene using an alkali metal alcoholate; and subjecting the salt formation reaction mixture to carboxylation using carbon dioxide gas.