21352-19-2

Basic information

• Product Name: N-(2-Chloro-3-pyridinyl)-acetamide
• Synonyms: N-(2-Chloro-3-pyridinyl)-acetamide
• CAS NO: 21352-19-2
• Molecular Formula: C₇H₇ClN₂O
• Molecular Weight: 170.6
• Product Categories: pharmacetical
• Mol File: 21352-19-2.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 347.7°Cat760mmHg
• Flash Point: 164.1°C
• Appearance: /
• Density: 1.336g/cm³
• Vapor Pressure: 5.29E-05mmHg at 25°C
• Refractive Index: 1.597
• CAS DataBase Reference: N-(2-Chloro-3-pyridinyl)-acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-Chloro-3-pyridinyl)-acetamide(21352-19-2)
• EPA Substance Registry System: N-(2-Chloro-3-pyridinyl)-acetamide(21352-19-2)

Safety Data

• Hazardous Substances Data: 21352-19-2(Hazardous Substances Data)

Usage

InChI:InChI=1/C7H7ClN2O/c1-5(11)10-6-3-2-4-9-7(6)8/h2-4H,1H3,(H,10,11)

Upstream product

• 6298-19-7 2-chloro-3-aminopyridine 
• 75-05-8 acetonitrile 
• 108-24-7 acetic anhydride 
• 64-19-7 acetic acid 
• 3240-34-4 [bis(acetoxy)iodo]benzene 
• 6602-54-6 2-chloro-3-pyridinecarbonitrile 
• 39620-04-7 2-amino-3-chloropyridine 
• 75-36-5 acetyl chloride 
• 584-08-7 potassium carbonate 
• 5470-18-8 2-Chloro-3-nitropyridine 
• 462-08-8 pyridin-3-ylamine 

Downstream Products

• 31557-57-0 2-chloro-3-phenyl-pyridine 
• 959855-46-0 2-methyl-3-(2-methylphenyl)-3H-imidazo[4,5-b]pyridine 
• 117087-45-3 (2-chloropyridin-3-yl)hydrazine 
• 91813-40-0 2-methylthiazolo[5,4-b]pyridine 
• 91813-42-2 2-(2-methyl)oxazolo<5,4-b>pyridine 
• 138768-66-8 1-(4-Methyl-3,4-dihydro-2H-pyrido[2,3-b]pyrazin-1-yl)-ethanone 

Relevant articles and documents

Synthesis and indole coupling reactions of azetidine and oxetane sulfinate salts

Aztidine and oxetane sulfinate salts are easily prepared from commercially available 3-iodoheterocycle precursors in a three-step sequence. They undergo smooth coupling reactions thereby providing an expedient route for the introduction of these four-membered heterocycles into indoles.

SMALL MOLECULE INHIBITORS OF DYRK/CLK AND USES THEREOF

This invention is in the field of medicinal chemistry. In particular, the invention relates to a new class of small-molecules having a 6,5-heterocyclic structure (e.g., compounds having a imidazopyridine, imidazopyrimidine, imidazopyrazine, imidazopyridazine, imidazotriazine, benzoimidazole, benzotriazole, benzoisoxazole, purine, indazole, triazolotriazine, triazolopyridazine, triazolopyrimidine, triazolopyrazine, triazolotetrazine, triazolopyridine, pyrazolopyrazine, pyrazolopyrimidine, pyrazolopyridazine, pyrazolotriazine, pyrazolopyridine, isoxazolopyrazine, isoxazolopyrimidine, isoxazolopyrdiazine, isoxazolotriazine, or isoxalopyridine structure) which function as inhibitors of DYRK1A, DYRK1B, and Clk-1, and their use as therapeutics for the treatment of Alzheimer's disease, Down syndrome, diabetes, glioblastoma, autoimmune diseases, cancer (e.g., glioblastoma, prostate cancer), inflammatory disorders (e.g., airway inflammation), and other diseases.

A new transformation of aminopyridines upon diazotization in acetonitrile with the formation of N-pyridinylacetamides

Diazotization of aminopyridines upon treatment with NaNO2 and H3PO4 in acetonitrile led to the formation of N-pyridinylacetamides. This reaction constitutes a convenient and general preparative method for the synthesis of 2-, 3-, and 4-N-pyridinylacetamides under mild conditions in good yields. The in situ oxidation of the thus obtained N-pyridinylacetamides with hydrogen peroxide gave good yields of pyridinylacetamide N-oxides.