3158-98-3

Usage

Chemical Properties

Off-White Solid

InChI:InChI=1/C14H14ClNO/c1-14(17,10-5-3-2-4-6-10)12-9-11(15)7-8-13(12)16/h2-9,17H,16H2,1H3

Upstream product

• 917-64-6 methyl magnesium iodide 
• 719-59-5 5-chloro-2-aminobenzophenone 
• 1685-19-4 2-amino-5-chloroacetophenone 
• 100-58-3 phenylmagnesium bromide 
• 75-16-1 methylmagnesium bromide 
• 74-88-4 methyl iodide 

Downstream Products

• 68054-98-8 C₁₇H₁₆Cl₂N₂O₂ 
• 68055-00-5 C₂₀H₂₂Cl₂N₂O₃ 
• 30169-33-6 6-Chlor-1,2-dihydro-4-phenylchinolin-2-on 
• 3159-01-1 4-chloro-2-(1-phenylethyl)benzenamine 
• 3159-00-0 N-[4-chloro-2-(1-phenylethenyl)phenyl]acetamide 
• 858621-43-9 7-acetyl-3-chloro-8-iodomethyl-8-phenylbicyclo[4.2.0]-7-azaocta-1,3,5-triene 
• 3158-99-4 1-phenyl-1-(2-amino-5-chlorophenyl)ethylene 
• 68055-01-6 C₂₁H₁₇Cl₂N₃O₃ 
• 68182-92-3 C₂₁H₁₈Cl₂N₂O₃S 
• 68054-99-9 C₂₂H₁₈Cl₂N₂O₂ 

Relevant academic research and scientific papers

DEUTERATED ANALOGS OF ETIFOXINE, THEIR DERIVATIVES AND USES THEROF

This invention relates to deuterated analogs of etifoxine of Formula 1, solvates, prodrugs, and pharmaceutically acceptable salts thereof, as well as to methods for their preparation and use, and to pharmaceutical compositions. Briefly, this invention is generally directed to deuterated analogs of etifoxine as well as to methods for their preparation and use, and to pharmaceutical compositions containing the same.

Beyond a Protecting Reagent: DMAP-Catalyzed Cyclization of Boc-Anhydride with 2-Alkenylanilines

A novel rapid synthesis of quinolines from 2-alkenylanilines has been described; the reaction involves an unexpected DMAP-catalyzed cyclization of 2-alkenylanilines with di-tert-butyl dicarbonate (Boc2O, 2.0 equiv), and a series of tert-butyl quinolin-2-yl carbonate with various functional groups have been synthesized in good yields under mild conditions. Furthermore, the tert-butyl quinolin-2-yl carbonate can be easily converted into corresponding quinolinones and 2-(pseudo)haloquinolines.

Synthesis of benzazetine derivatives by intramolecular iodoamination of o-(acylamino)styrene derivatives

The iodoamination of o-(acylamino)styrene derivatives using iodine and sodium hydrogencarbonate, producing 7-acyl-8-iodomethylbicyclo[4.2.0]-7-azaoct- 1,3,5-triene [1-acyl-2-(iodomethyl)benzazetine] derivatives, is described. Replacement of the iodo moiety by hydrogen or phenylthio group is also reported.