317318-65-3

Upstream product

• 1706-60-1 (4-Mercapto-phenoxy)-acetic Acid Methyl Ester 
• 317318-97-1 5-(chloromethyl)-4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole 
• 317318-96-0 [4-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-yl]-methanol 
• 86487-19-6 tributyl(4-(trifluoromethyl)phenyl)stannane 
• 402-43-7 p-trifluoromethylphenyl bromide 
• 637-89-8 4-sulfanylphenol 
• 15015-57-3 bis(4-hydroxyphenyl)disulfide 
• 167012-47-7 methyl [4-(4-[methoxycarbonylmethoxy]phenyldithio)phenoxy]acetate 
• 873066-26-3 [4-bromo-2-(4-trifluoromethylphenyl)thiazol-5-yl]methanol 
• 873066-23-0 4-trifluoromethylphenylboronic dimethyl ester 

Relevant academic research and scientific papers

Synthesis of the PPARβ/δ-selective agonist GW501516 and C4-thiazole-substituted analogs

Sequential, position-selective, Pd-catalyzed cross-coupling reactions of 2,4-dibromo-5-hydroxymethylthiazole provided the scaffold for the synthesis of GW501516, the most potent PPARβ/δ agonist yet described, and equally selective analogs at the thiazole-

Medicaments

Methods or prevention or treatment of diseases or conditions where inhibition of NO synthase and/or TNF is desirable, the use of PPAR delta activators in such methods and methods for the identification of compounds useful in such treatment.

Activator of PPAR delta

Compounds of Formula (I) are disclosed. These compounds include selective activators of human PPAR delta.