318237-73-9

Basic information

• Product Name: 2-Methyl-1,4,5,6-tetrahydroimidazo[4,5-d][1]benzazepine
• Synonyms: 2-Methyl-1,4,5,6-tetrahydroimidazo[4,5-d][1]benzazepine;1,4,5,6-Tetrahydro-2-methyl-imidazo[4,5-d][1]benzazepine;2-methyl-1,4,5,6-tetrahydrobenzo[b]imidazo[4,5-d]azepine;Conivaptan hydrochkoride Impurity C;Conivaptan Hydrochloride impurity C;2-methyl-3,4,5,6-tetrahydroimidazo[4,5-d][1]benzazepine
• CAS NO: 318237-73-9
• Molecular Formula: C₁₂H₁₃N₃
• Molecular Weight: 199.25
• Product Categories: pharmaceutical intermediare
• Mol File: 318237-73-9.mol
• Article Data: 3

Chemical Properties

• Melting Point: 178-180 ºC
• Boiling Point: 529.2 °C at 760 mmHg
• Flash Point: 273.8 °C
• Appearance: /
• Density: 1.188
• Vapor Pressure: 2.77E-11mmHg at 25°C
• Refractive Index: 1.622
• PKA: 14.52±0.20(Predicted)
• CAS DataBase Reference: 2-Methyl-1,4,5,6-tetrahydroimidazo[4,5-d][1]benzazepine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Methyl-1,4,5,6-tetrahydroimidazo[4,5-d][1]benzazepine(318237-73-9)
• EPA Substance Registry System: 2-Methyl-1,4,5,6-tetrahydroimidazo[4,5-d][1]benzazepine(318237-73-9)

Safety Data

• Hazardous Substances Data: 318237-73-9(Hazardous Substances Data)

Usage

Uses

2-Methyl-1,4,5,6-tetrahydrobenzo[b]imidazo[4,5-d]azepine is an impurity of Conivaptan(C384700). Conivaptan is used in the treatment of congestive heart failures.

InChI:InChI=1/C12H13N3/c1-8-14-11-6-7-13-10-5-3-2-4-9(10)12(11)15-8/h2-5,13H,6-7H2,1H3,(H,14,15)

Upstream product

• 877858-24-7 6-benzoyl-2-methyl-1,4,5,6-tetrahydro-1,3,6-triaza-benzo[e]azulene 
• 105895-93-0 methyl 2-{(3-cyanopropyl)[(4-methylphenyl)sulfonyl]amino}benzoate 
• 134-20-3 2-carbomethoxyaniline 
• 68595-19-7 1-[(4-methylphenyl)sulfonyl]-5-oxo-2,3,4,5-tetrahydro-1H-1-benzazepine-4-carbonitrile 
• 24310-36-9 1-tosyl-2,3,4,5-tetrahydro-1H-1-benzazepin-5-one 
• 50998-74-8 methyl N-tosylanthranilate 
• 29489-04-1 4-bromo-1-[(4-methylphenyl)sulfonyl]-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one 
• 717917-14-1 2-methyl-6-[(4-methylphenyl)sulfonyl]-1,4,5,6-tetrahydroimidazo[4,5-d][1]benzazepine 

Downstream Products

• 168626-94-6 conivaptan hydrochloride 
• 195531-22-7 {4-[(2-methyl-4,5-dihydroimidazo[4,5-d][1]benzazepin-6(1H)-yl)carbonyl]phenyl}amine 

Relevant articles and documents

VASOPRESSIN V1A ANTAGONISTS

The present invention concerns compounds inter alia according to general formula 1a. Compounds according to the invention are vasopressin V 1a receptor antagonists. Pharmaceutical compositions of the compounds are useful as treatment of dysmenorrhoea.

A new synthetic route to YM087, an arginine vasopressin antagonist

A new synthesis of N-{4-[(2-methyl-4,5-dihydroimidazo[4,5-d][1]benzazepin-6(1H)-yl)carbonyl]phenyl} biphenyl-2-carboxamide monohydrochloride (1, YM087) via new imidazobenzazepine intermediates is described. This method remarkably improves the overall yiel