3197-57-7Relevant academic research and scientific papers
Solvent free one-pot multi-component synthesis of β-azaarene substituted ketones via a Sn-catalyzed C(sp3)-H functionalization of 2-alkylazaarenes
Chavan, Santosh S.,Pathan, Mohsinkhan Y.,Mulla, Shafeek A. R.
, p. 103091 - 103094 (2015/12/23)
A tin-catalyzed solvent free one-pot multi-component cascade reaction strategy for the direct Michael addition/C(sp3)-H functionalization of 2-alkylazaarenes with aldehydes and ketones via an aldol reaction has been developed. This is the first report and provides cost effective new access to potent biologically/medicinally important azaarene derivatives with high atom economy.
SITE SELECTIVE EFFECT OF N-OXIDE FUNCTION TO METHYL GROUPS ON SIX-MEMBERED N-HETEROAROMATICS
Sakamoto, Takao,Yoshizawa, Hiroshi,Yamanaka, Hiroshi,Goto, Yoshinobu,Niiya, Tokihiro,Honjo, Noriko
, p. 73 - 76 (2007/10/02)
Reaction of 2,4-dimethylpyridine 1-oxide with ethyl benzoate under basic conditions afforded 4-methyl-2-phenacylpyridine 1-oxide, while the same reaction of 2,4-dimethylpyridine itself is known to afford 2-methyl-4-phenacylpyridine.Concerning the above contrast, the effect of N-oxide function to the relative reactivity of the 2- and 4-methyl group was investigated on pyridine, quinoline, pyrimidine, and quinazoline homologues.The higher reactivity of α-methyl groups was concluded to be general in the N-oxides of these N-heteroaromatics.
