32084-53-0

Basic information

• Product Name: ETHYL 5-OXO-2,3-DIHYDRO-5H-PYRIMIDO[2,1-B][1,3]THIAZOLE-6-CARBOXYLATE
• Synonyms: ETHYL 5-OXO-2,3-DIHYDRO-5H-[1,3]THIAZOLO[3,2-A]PYRIMIDINE-6-CARBOXYLATE;ETHYL 5-OXO-2,3-DIHYDRO-5H-PYRIMIDO[2,1-B][1,3]THIAZOLE-6-CARBOXYLATE;Ethyl 5-oxo-2,3-dihydro-5H-[1,3]thiazolo[3,2-b]pyrimidine-6-carboxylate;ETHYL 2,3-DIHYDRO-5-OXOTHIAZOLO(3,2-A)PYRIMIDINE-6-CARBOXYLATE;Ethyl 5-oxo-3,5-dihydro-2H-thiazolo[3,2-a]pyriMidine-6-carboxylate;Ethyl 5-oxo-2H,3H-[1,3]thiazolo[3,2-a]pyriMidine-6-carboxylate
• CAS NO: 32084-53-0
• Molecular Formula: C₉H₁₀N₂O₃S
• Molecular Weight: 226.25
• Product Categories: pyrimidine;Heterocycle-Pyrimidine series
• Mol File: 32084-53-0.mol
• Article Data: 3

Chemical Properties

• Melting Point: 175 °C
• Boiling Point: 357.8°Cat760mmHg
• Flash Point: 170.2°C
• Appearance: /
• Density: 1.5g/cm³
• Vapor Pressure: 2.03E-05mmHg at 25°C
• Refractive Index: 1.675
• Storage Temp.: 2-8°C
• CAS DataBase Reference: ETHYL 5-OXO-2,3-DIHYDRO-5H-PYRIMIDO[2,1-B][1,3]THIAZOLE-6-CARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 5-OXO-2,3-DIHYDRO-5H-PYRIMIDO[2,1-B][1,3]THIAZOLE-6-CARBOXYLATE(32084-53-0)
• EPA Substance Registry System: ETHYL 5-OXO-2,3-DIHYDRO-5H-PYRIMIDO[2,1-B][1,3]THIAZOLE-6-CARBOXYLATE(32084-53-0)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 32084-53-0(Hazardous Substances Data)

Usage

General Description

ETHYL 5-OXO-2,3-DIHYDRO-5H-PYRIMIDO[2,1-B][1,3]THIAZOLE-6-CARBOXYLATE is a chemical compound that belongs to the class of pyrimidine derivatives. It contains an ethyl ester functional group, a carbonyl group, and a dihydro-5H-pyrimido-thiazole ring system. ETHYL 5-OXO-2,3-DIHYDRO-5H-PYRIMIDO[2,1-B][1,3]THIAZOLE-6-CARBOXYLATE has potential applications in medicinal chemistry and drug development due to its unique structural features. It may exhibit biological activities and pharmacological properties that could be beneficial for the treatment of various diseases. Further research and studies are necessary to explore the potential uses and properties of ETHYL 5-OXO-2,3-DIHYDRO-5H-PYRIMIDO[2,1-B][1,3]THIAZOLE-6-CARBOXYLATE.

InChI:InChI=1/C9H8N2O3S/c1-2-14-8(13)6-5-10-9-11(7(6)12)3-4-15-9/h3-5H,2H2,1H3

Upstream product

• 106-93-4 ethylene dibromide 
• 36239-09-5 ethyl chlorocarbonylacetate 
• 1779-81-3 4,5-Dihydro-thiazol-2-ylamin 
• 87-13-8 diethyl 2-ethoxymethylenemalonate 

Downstream Products

• 93501-51-0 5-Oxo-2,3-dihydro-5H-thiazolo[3,2-a]pyrimidine-6-carboxylic acid (3-trifluoromethyl-phenyl)-amide 
• 93501-52-1 5-Oxo-2,3-dihydro-5H-thiazolo[3,2-a]pyrimidine-6-carboxylic acid N'-phenyl-hydrazide 
• 93501-16-7 (5-Oxo-2,3-dihydro-5H-thiazolo[3,2-a]pyrimidin-6-yl)-carbamic acid phenyl ester 
• 93501-50-9 5-Oxo-2,3-dihydro-5H-thiazolo[3,2-a]pyrimidine-6-carboxylic acid cyclohexylamide 
• 32084-55-2 2,3-dihydro-5(H)-oxothiazolo<3,2-a>pyrimidine-6-carboxylic acid 
• 51068-10-1 2,3-Dihydrothiazolo<3,2-c>-pyrimidin-5-on 

Relevant articles and documents

N- vs. S-PTC alkylation of 5-carboethoxy-2-thiouracil and its reactivity towards some nucleophilic reagents

The reactivity of 5-carboethoxy-2-thiouracil (1) toward alkylation by different organohalogen compounds under phase-transfer catalysis (PTC) conditions has been investigated to give S-monoalkylated products and/or simultaneous S- and N-dialkylated product

Synthesis & Biological Activity of Some New Carboxamides, Carbohydrazides & Carbamates Derived from 2,3-Dihydro-5(H)-oxothiazolopyrimidine-6-carboxylic Acid

Some new carboxamides (Va-j), carbohydrazides (Vk-p) and carbamates (VIIIa-d) derived from 2,3-dihydro-5(H)-oxothiazolopyrimidine-6-carboxylic acid (III) have been synthesised and evaluated for their antiinflammatory, antibacterial, antifungal and anthelmintic activities.The carboxamides (Ve,i,j) and carbohydrazides (Vk,n,o) possess promising antiinflammatory activity against carrageenin-induced paw oedema in rats, compound Ve being the most active member of the series showing 50.8 percent inhibition at 200 mg/kg (p.o.) dose.Ve, however, is found to be inactive at lower doses.None of the compounds shows any noteworthy antibacterial, antifungal or anthelmintic activities except Vk which displays promising antitubercular activity in vitro (MIC=5 mcg/ml) against Mycobacterium tuberculosis H37Rv.