32084-53-0

Usage

Uses

Used in Medicinal Chemistry:
ETHYL 5-OXO-2,3-DIHYDRO-5H-PYRIMIDO[2,1-B][1,3]THIAZOLE-6-CARBOXYLATE is used as a chemical intermediate for the synthesis of new pharmaceutical compounds due to its unique structural features and potential biological activities.
Used in Drug Development:
In the pharmaceutical industry, ETHYL 5-OXO-2,3-DIHYDRO-5H-PYRIMIDO[2,1-B][1,3]THIAZOLE-6-CARBOXYLATE is used as a lead compound for the development of novel therapeutic agents, given its potential pharmacological properties that could be beneficial for treating various diseases.

InChI:InChI=1/C9H8N2O3S/c1-2-14-8(13)6-5-10-9-11(7(6)12)3-4-15-9/h3-5H,2H2,1H3

Upstream product

• 1779-81-3 4,5-Dihydro-thiazol-2-ylamin 
• 87-13-8 diethyl 2-ethoxymethylenemalonate 
• 36239-09-5 ethyl chlorocarbonylacetate 
• 106-93-4 ethylene dibromide 

Downstream Products

• 51068-10-1 2,3-Dihydrothiazolo<3,2-c>-pyrimidin-5-on 
• 32084-55-2 2,3-dihydro-5(H)-oxothiazolo<3,2-a>pyrimidine-6-carboxylic acid 
• 93501-51-0 5-Oxo-2,3-dihydro-5H-thiazolo[3,2-a]pyrimidine-6-carboxylic acid (3-trifluoromethyl-phenyl)-amide 
• 93501-52-1 5-Oxo-2,3-dihydro-5H-thiazolo[3,2-a]pyrimidine-6-carboxylic acid N'-phenyl-hydrazide 
• 93501-16-7 (5-Oxo-2,3-dihydro-5H-thiazolo[3,2-a]pyrimidin-6-yl)-carbamic acid phenyl ester 
• 93501-50-9 5-Oxo-2,3-dihydro-5H-thiazolo[3,2-a]pyrimidine-6-carboxylic acid cyclohexylamide 

Relevant academic research and scientific papers

N- vs. S-PTC alkylation of 5-carboethoxy-2-thiouracil and its reactivity towards some nucleophilic reagents

The reactivity of 5-carboethoxy-2-thiouracil (1) toward alkylation by different organohalogen compounds under phase-transfer catalysis (PTC) conditions has been investigated to give S-monoalkylated products and/or simultaneous S- and N-dialkylated product

A facile access to imidazo[2,1-b]thiazole and thiazolo[3,2-a]pyrimidine derivatives

A new and efficient method for the synthesis of 2,3-dihydroimidazo [2,1-b]thiazoles 3, 2,3-dihydro-5H-thiazolo[3,2-a]pyrimidin-5-ones 4 and 2,3-dihydro-5H-thiazolo[3,2-a]pyrimidines 5 has been developed. The reactions of N′-(4,5-dihydrothiazol-2-yl)-N,N-dimethylamidines 1 with α-halogenoketones, acid chlorides or acrylic dienophiles were performed, leading to the title products.

Synthesis & Biological Activity of Some New Carboxamides, Carbohydrazides & Carbamates Derived from 2,3-Dihydro-5(H)-oxothiazolopyrimidine-6-carboxylic Acid

Some new carboxamides (Va-j), carbohydrazides (Vk-p) and carbamates (VIIIa-d) derived from 2,3-dihydro-5(H)-oxothiazolopyrimidine-6-carboxylic acid (III) have been synthesised and evaluated for their antiinflammatory, antibacterial, antifungal and anthelmintic activities.The carboxamides (Ve,i,j) and carbohydrazides (Vk,n,o) possess promising antiinflammatory activity against carrageenin-induced paw oedema in rats, compound Ve being the most active member of the series showing 50.8 percent inhibition at 200 mg/kg (p.o.) dose.Ve, however, is found to be inactive at lower doses.None of the compounds shows any noteworthy antibacterial, antifungal or anthelmintic activities except Vk which displays promising antitubercular activity in vitro (MIC=5 mcg/ml) against Mycobacterium tuberculosis H37Rv.