ETHYL 5-OXO-2,3-DIHYDRO-5H-PYRIMIDO[2,1-B][1,3]THIAZOLE-6-CARBOXYLATE

Base Information

• Chemical Name: ETHYL 5-OXO-2,3-DIHYDRO-5H-PYRIMIDO[2,1-B][1,3]THIAZOLE-6-CARBOXYLATE
• CAS No.: 32084-53-0
• Molecular Formula: C₉H₁₀N₂O₃S
• Molecular Weight: 226.256
• Hs Code.: 2934100090
• Mol file: 32084-53-0.mol

Synonyms:ETHYL 5-OXO-2,3-DIHYDRO-5H-[1,3]THIAZOLO[3,2-A]PYRIMIDINE-6-CARBOXYLATE;ETHYL 5-OXO-2,3-DIHYDRO-5H-PYRIMIDO[2,1-B][1,3]THIAZOLE-6-CARBOXYLATE;Ethyl 5-oxo-2,3-dihydro-5H-[1,3]thiazolo[3,2-b]pyrimidine-6-carboxylate;ETHYL 2,3-DIHYDRO-5-OXOTHIAZOLO(3,2-A)PYRIMIDINE-6-CARBOXYLATE

Chemical Property of ETHYL 5-OXO-2,3-DIHYDRO-5H-PYRIMIDO[2,1-B][1,3]THIAZOLE-6-CARBOXYLATE

Chemical Property:

• Vapor Pressure: 2.03E-05mmHg at 25°C
• Melting Point: 175 °C
• Boiling Point: 357.8°Cat760mmHg
• Flash Point: 170.2°C
• PSA: 86.49000
• Density: 1.5g/cm³
• LogP: 0.52570
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

Ethyl5-oxo-2H,3H-[1,3]thiazolo[3,2-a]pyrimidine-6-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ETHYL 5-OXO-2,3-DIHYDRO-5H-PYRIMIDO[2,1-B][1,3]THIAZOLE-6-CARBOXYLATE

There total 3 articles about ETHYL 5-OXO-2,3-DIHYDRO-5H-PYRIMIDO[2,1-B][1,3]THIAZOLE-6-CARBOXYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

ethyl chlorocarbonylacetate (36239-09-5) + N'-(4,5-dihydrothiazol-2-yl)-N,N-dimethylformamidine → ethyl 5-oxo-2,3-dihydro-5H-[1,3]thiazolo[3,2-a]-pyrimidine-6-carboxylate (32084-53-0)

Guidance literature:

ethyl chlorocarbonylacetate; N'-(4,5-dihydrothiazol-2-yl)-N,N-dimethylformamidine; In dichloromethane; at 20 ℃; for 4h;

With triethylamine; In dichloromethane; at 20 ℃; for 16h;

DOI:10.1055/s-2001-17718

Reference yield: 76.0%

ethylene dibromide (106-93-4) + ethyl 2-mercapto-6-oxo-1,6-dihydropyrimidine-5-carboxylate → ethyl 5-oxo-2,3-dihydro-5H-[1,3]thiazolo[3,2-a]-pyrimidine-6-carboxylate (32084-53-0)

Guidance literature:

With tetrabutylammomium bromide; potassium carbonate; In benzene; at 70 ℃;

DOI:10.1080/714040963

Reference yield:

4,5-Dihydro-thiazol-2-ylamin (1779-81-3) + diethyl 2-ethoxymethylenemalonate (87-13-8) → ethyl 5-oxo-2,3-dihydro-5H-[1,3]thiazolo[3,2-a]-pyrimidine-6-carboxylate (32084-53-0)

Guidance literature:

for 1h; Heating;

DOI:10.1039/j39710001527

upstream raw materials:

4,5-Dihydro-thiazol-2-ylamin

diethyl 2-ethoxymethylenemalonate

ethyl chlorocarbonylacetate

ethylene dibromide

Downstream raw materials:

2,3-Dihydrothiazolo<3,2-c>-pyrimidin-5-on

2,3-dihydro-5(H)-oxothiazolo<3,2-a>pyrimidine-6-carboxylic acid

5-Oxo-2,3-dihydro-5H-thiazolo[3,2-a]pyrimidine-6-carboxylic acid cyclohexylamide

(5-Oxo-2,3-dihydro-5H-thiazolo[3,2-a]pyrimidin-6-yl)-carbamic acid phenyl ester