32151-02-3

Basic information

• Product Name: (1S,2S)-2-Amino-2,3-dihydro-1H-inden-1-ol
• Synonyms: (1S,2S)-2-Amino-2,3-dihydro-1H-inden-1-ol
• CAS NO: 32151-02-3
• Molecular Formula: C₉H₁₁NO
• Molecular Weight: 149
• Mol File: 32151-02-3.mol
• Article Data: 5

Chemical Properties

• Melting Point: 160-161℃
• Boiling Point: 297℃
• Flash Point: 57℃
• Appearance: /
• Density: 1.212
• CAS DataBase Reference: (1S,2S)-2-Amino-2,3-dihydro-1H-inden-1-ol(CAS DataBase Reference)
• NIST Chemistry Reference: (1S,2S)-2-Amino-2,3-dihydro-1H-inden-1-ol(32151-02-3)
• EPA Substance Registry System: (1S,2S)-2-Amino-2,3-dihydro-1H-inden-1-ol(32151-02-3)

Safety Data

• Hazardous Substances Data: 32151-02-3(Hazardous Substances Data)

Usage

General Description

(1S,2S)-2-Amino-2,3-dihydro-1H-inden-1-ol, also known as quinolizidine, is a chemical compound that belongs to the class of indenols. It is a chiral molecule with two stereocenters. (1S,2S)-2-Amino-2,3-dihydro-1H-inden-1-ol has been studied for its potential applications in organic synthesis and pharmaceuticals. It has also been found to exhibit biological activity, including anti-inflammatory and analgesic properties. The compound's unique structure and functional groups make it a promising candidate for further research and development in the field of medicinal chemistry. Overall, (1S,2S)-2-Amino-2,3-dihydro-1H-inden-1-ol has the potential for various uses in both the chemical and pharmaceutical industries.

Upstream product

• 1775-27-5 2-bromoindanone 
• 83-33-0 inden-1-one 
• 74036-09-2 2-(1-oxo-indan-2-yl)-isoindole-1,3-dione 
• 29365-64-8 (1R,2R)-(-)-2-phthalimidoindan-1-ol 
• 15028-10-1 indan-1,2-dione-2-oxime 
• 171285-94-2 (1R,2R)-2-azido-2,3-dihydro-1H-inden-1-yl-4-nitrobenzoate 
• 166942-30-9 (1S,2R)-2-azido-2,3-dihydro-1H-inden1-ol 
• 2338-18-3 2-aminoindane hydrochloride 
• 171482-71-6 (1R,2R)-2-azido-2,3-dihydro-1H-inden-1-ol 
• 13575-72-9 2-amino-1-indanol 

Downstream Products

• 94077-02-8 (+)-(1S,2S)-2-benzylideneaminoindan-1-ol 
• 94133-00-3 (+)-(1S,2S)-2-benzylaminoindan-1-ol 
• 94077-17-5 (+)-(1S,2S)-2-(3-methoxybenzylamino)indan-1-ol 
• 94077-18-6 (+)-(1S,2S)-2-(3,4-dimethoxybenzylamino)indan-1-ol 
• 94077-19-7 (+)-(1S,2S)-2-(2,3-dimethoxybenzylamino)indan-1-ol 
• 94077-19-7 (1R,2R)-2-(2,3-Dimethoxy-benzylamino)-indan-1-ol 
• 94077-17-5 (1R,2R)-2-(3-Methoxy-benzylamino)-indan-1-ol 
• 23672-01-7 (-)-(1R,2R)-2-benzylaminoindan-1-ol 
• 94077-04-0 (1R,2R)-2-{[1-(2,3-Dimethoxy-phenyl)-meth-(E)-ylidene]-amino}-indan-1-ol 
• 94077-04-0 (+)-(1S,2S)-2-(2,3-dimethoxybenzylideneamino)indan-1-ol 
• 94077-03-9 (1R,2R)-2-{[1-(3-Methoxy-phenyl)-meth-(E)-ylidene]-amino}-indan-1-ol 
• 94077-03-9 (+)-(1S,2S)-2-(3-methoxybenzylideneamino)indan-1-ol 
• 94089-26-6 (+)-(1S,2S)-2-(3,4-dimethoxybenzylideneamino)indan-1-ol 
• 144285-04-1 (1R,2R)-2-(2-hydroxybenzylideneamino)-1-indanol 

Relevant articles and documents

Cyclic trans-β-amino alcohols: Preparation and enzymatic kinetic resolution

Enantioenriched cyclic β-amino alcohols, trans-2-aminocyclohexanols (ee, >99%), trans-2-aminocyclopentanols (ee, >99%), trans-1-amino-2- indanols (ee, >99%) and trans-2-amino-1-indanols (ee, ～98%) were prepared in high yields via an Arthrobacter sp. Lipase/PLAP catalyzed kinetic resolution of racemic phthalimido acetates. The addition of toluene as a co-solvent dramatically improved the hydrolysis and enantioselectivity, whereas for indanols, substrate immobilization on Celite improved the efficacy of the kinetic resolution.

Stereoselective synthesis of 1,2-amino alcohols by asymmetric borane reduction of α-oxoketoxime ethers

Asymmetric reduction of α-oxoketoxime ethers with the reagents prepared in situ from trimethyl borate and chiral amino alcohols derived from either L-proline or α-pinene was investigated. Both cyclic and acyclic α- oxoketoxime ethers were reduced to afford the corresponding chiral 1,2amino alcohols with high enantioselectivities.

COPPER(II) IN ORGANIC SYNTHESIS. X. THE IMPORTANCE OF STERIC HINDRANCE IN THE DESIGN OF CHIRAL TRIDENTATE LIGAND COPPER(II) CATALYSTS FOR ENANTIOSELECTIVE MICHAEL REACTIONS

Several copper(II) complexes with tridentate chiral ligands derived from 2-substituted 2-aminoethanols have been tested as catalysts for enantioselective Michael reactions.The degree of enantioselection increases with the increase of the steric hindrance of the substituents and the best result (65percent e.e.) was obtained with the benzyl-substituted catalyst.A comparison of these results with those obtained with complexes derived from 2-amino-1-indanols gives useful information about the requirements for the optimization of the catalyst design.