321575-57-9Relevant academic research and scientific papers
Enantioselective Michael addition of nitromethane to α,β-enones catalyzed by chiral quaternary ammonium salts. A simple synthesis of (R)-baclofen
Corey,Zhang, Fu-Yao
, p. 4257 - 4258 (2000)
(equation presented) R/S = 85/15, 97.5/2 after recryst. Enantioselective Michael addition of nitromethane to an α,β-enone is a key step in the synthesis of (R)-baclofen.
Primary amine-thioureas with improved catalytic properties for "difficult" Michael reactions: Efficient organocatalytic syntheses of (S)-baclofen, (R)-baclofen and (S)-phenibut
Tsakos, Michail,Kokotos, Christoforos G.,Kokotos, George
supporting information; experimental part, p. 740 - 746 (2012/05/04)
Among the class of primary amine-thioureas based on tert-butyl esters of α-amino acids, the most efficient organocatalyst for "difficult" Michael reactions was identified. The derivative based on (S)-di-tert-butyl aspartate and (1R,2R)-diphenylethylenedia
