Enantioselective Michael addition of nitromethane to α,β-enones catalyzed by chiral quaternary ammonium salts. A simple synthesis of (R)-baclofen

Article abstract of DOI:10.1021/ol0068344

(equation presented) R/S = 85/15, 97.5/2 after recryst. Enantioselective Michael addition of nitromethane to an α,β-enone is a key step in the synthesis of (R)-baclofen.