322-33-8

Usage

Uses

Used in Pharmaceutical Industry:
N-(3-Fluoro-2-methylphenyl)acetamide is used as a pharmaceutical agent for its analgesic and anti-inflammatory properties, contributing to the development of new drugs for pain management. Its potential in this area is supported by its ability to alleviate pain and reduce inflammation, making it a promising candidate for further research and development.
Used in Organic Synthesis:
In the field of organic synthesis, N-(3-Fluoro-2-methylphenyl)acetamide is used as a building block, facilitating the creation of more complex molecules and compounds. Its structural features allow it to be a versatile component in the synthesis of various organic compounds.
Used in Chemical Reactions:
As a reagent in chemical reactions, N-(3-Fluoro-2-methylphenyl)acetamide plays a crucial role in various processes, enabling specific transformations and facilitating desired outcomes in chemical research and development. Its reactivity and stability make it a valuable tool for scientists and researchers working with chemical reactions.

Upstream product

• 443-86-7 3-fluoro-2-methylaniline 
• 108-24-7 acetic anhydride 
• 75-36-5 acetyl chloride 
• 127-19-5 N,N-dimethyl acetamide 
• 875145-55-4 2-fluoro-3-methyl-4-(acetyl)aminophenyl iodide 
• 124-38-9 carbon dioxide 
• 329927-16-4 2-fluoro-3-methyl-4-aminophenyl iodide 
• 769-10-8 1-fluoro-2-methyl-3-nitrobenzene 

Downstream Products

• 757247-91-9 N-(4-Bromo-3-fluoro-2-methylphenyl)acetamide 
• 1374606-66-2 N-(3-fluoro-2-methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetamide 
• 757247-92-0 N-(4-Cyano-3-fluoro-2-methylphenyl)acetamide 
• 757247-94-2 2-Fluoro-4-isocyanato-3-methylbenzonitrile 
• 757247-93-1 4-Amino-2-fluoro-3-methylbenzonitrile 

Relevant academic research and scientific papers

Copper-(II) Catalyzed N-Formylation and N-Acylation of Aromatic, Aliphatic, and Heterocyclic Amines and a Preventive Study in the C-N Cross Coupling of Amines with Aryl Halides

A Cu-(II) catalyzed N-formylation and N-acylation of amines with moderate to excellent yields, using N, N-dimethyl formamide (DMF) and N, N-dimethyl acetamide (DMA) as a formyl and acylating sources in the presence of 1,2,4-triazole is reported. This novel, highly efficient and simple protocol shows broad substrate scope for aliphatic, aromatic, and heterocyclic amines. In addition, the conditions to prevent N-formylation and N-acylation impurities in the C?N cross coupling of amines and aryl halides are described typically when DMF and DMA are used as solvents, with various catalysts, ligands, and bases.

Synthesis and Herbicidal Activity of Triketone-Quinoline Hybrids as Novel 4-Hydroxyphenylpyruvate Dioxygenase Inhibitors

4-Hydroxyphenylpyruvate dioxygenase (EC 1.13.11.27, HPPD) is one of the most important targets for herbicide discovery. In the search for new HPPD inhibitors with novel scaffolds, triketone-quinoline hybrids were designed and subsequently optimized on the basis of the structure-activity relationship (SAR) studies. Most of the synthesized compounds displayed potent inhibition of Arabidopsis thaliana HPPD (AtHPPD), and some of them exhibited broad-spectrum and promising herbicidal activity at the rate of 150 g ai/ha by postemergence application. Most promisingly, compound III-l, 3-hydroxy-2-(2-methoxy-7-(methylthio)quinoline-3-carbonyl)cyclohex-2-enone (Ki = 0.009 ～M, AtHPPD), had broader spectrum of weed control than mesotrione. Furthermore, compound III-l was much safer to maize at the rate of 150 g ai/ha than mesotrione, demonstrating its great potential as herbicide for weed control in maize fields. Therefore, triketone-quinoline hybrids may serve as new lead structures for novel herbicide discovery.

Practical synthesis of a benzophenone-based NNRT inhibitor of HIV-1

A convergent synthesis of NNRTI 1 is described. The key step involves a direct coupling of acid chloride 4 with Grignard reagent 11 in the presence of bis[2-(N,N-dimethylamino)ethyl] ether that moderates the reactivity of the Grignard reagent to give benzophenone 7. An efficient 2-step process for the preparation of 2-fluoro-3-methyl-4-aminobenzoic acid (3) is also described.

FUSED PYRIDINE AND PYRAZINE DERIVATIVES AS KINASE INHIBITORS

A series of amino-substituted fused pyridine and pyrazine derivatives, in particular amino-substituted quinoline and quinoxaline derivatives, being selective inhibitors of PI3 kinase enzymes, are accordingly of benefit in medicine, for example in the treatment of inflammatory, autoimmune, cardiovascular, neurodegenerative, metabolic, oncological, nociceptive or ophthalmic conditions.

Enzymatic substrates derived from phenoxazinone and their use as developer in detection of microorganisms with peptidase activity

Novel enzymatic substrates of the general formula below: reaction media containing the same and their use for detecting and/or identifying and/or quantifying microorganisms expressing at least one peptidase activity.

Tandem optimization of target activity and elimination of mutagenic potential in a potent series of N-aryl bicyclic hydantoin-based selective androgen receptor modulators

Pharmacokinetic studies in cynomolgus monkeys with a novel prototype selective androgen receptor modulator revealed trace amounts of an aniline fragment released through hydrolytic metabolism. This aniline fragment was determined to be mutagenic in an Ames assay. Subsequent concurrent optimization for target activity and avoidance of mutagenicity led to the identification of a pharmacologically superior clinical candidate without mutagenic potential.

BICYCLIC MODULATORS OF ANDROGEN RECEPTOR FUNCTION

The invention provides compounds according to formula I wherein the substitutents are as described herein. Further provided are methods of using such compounds for the treatment of nuclear hormone receptor-associated conditions, such as age related diseases, for example sarcopenia. Also provided are pharmaceutical compositions containing such compounds and processes for preparing some of the compounds of the invention.