68692-74-0

Upstream product

• 925-90-6 ethylmagnesium bromide 
• 119-67-5 o-carboxybenzaldehyde 
• 127-08-2 potassium acetate 
• 34599-72-9 methyl 2-(prop-1-en-1-yl)benzoate 
• 16859-59-9 3-hydroxy-1(3H)-isobenzofuranone 
• 610-97-9 o-iodo-methyl-benzoic acid 
• 610-94-6 2-bromobenzoic acid methyl ester 
• 88-65-3 2-bromobenzoic-acid 
• 1530-32-1 ethyltriphenylphosphonium bromide 
• 124-38-9 carbon dioxide 
• 70913-21-2 (E)-1-bromo-2-(2-methylethenyl)benzene 
• 103441-58-3 1-(2-iodophenyl)propan-1-one 
• 144-62-7 oxalic acid 
• 93-55-0 1-phenyl-propan-1-one 

Downstream Products

• 1351766-10-3 2-p-tolyl-3-vinylisoindolin-1-one 
• 1351766-13-6 2-(3,4-dimethylphenyl)-3-vinylisoindolin-1-one 
• 1351766-15-8 2-(3,4-dimethylphenyl)-3-methylisoquinolin-1(2H)-one 
• 1351766-17-0 2-(2,4-dimethylphenyl)-3-vinylisoindolin-1-one 
• 1351766-19-2 2-(2,4-dimethylphenyl)-3-methylisoquinolin-1(2H)-one 
• 1351766-21-6 2-(4-chlorophenyl)-3-vinylisoindolin-1-one 
• 1351766-23-8 2-(4-chlorophenyl)-3-methylisoquinolin-1(2H)-one 
• 32346-23-9 (Z)-3-ethylidene-2-phenylisoindolin-1-one 
• 32346-24-0 (E)-3-ethylidene-2-phenylisoindolin-1-one 
• 1578268-60-6 2-(2-(3-(N-benzylsulfamoyl)-4-methoxyphenyl)-1-fluoroethyl)-N-(quinolin-8-yl)benzamide 
• 1578268-59-3 2-(1-fluoro-2-(p-tolyl)propyl)-N-(quinolin-8-yl)benzamide 
• 1578268-95-7 (E)-2-(prop-1-en-1-yl)-N-(quinolin-8-yl)benzamide 
• 73109-04-3 3-methyl-2-p-tolylisoquinolin-1(2H)-one 

Relevant academic research and scientific papers

Palladium-catalyzed: Ortho -halogen-induced deoxygenative approach of alkyl aryl ketones to 2-vinylbenzoic acids

The 2-vinylbenzoic acids have wide applications in the field of polymer chemistry and are key precursors for the synthesis of important bioactive molecules. Herein, an ortho-halogen-induced deoxygenative approach for the generation of 2-vinylbenzoic acids from alkyl aryl ketones by palladium catalysis is discovered and explored. This approach requires no base or stoichiometric additives and can be carried out through a simple one-step process. Furthermore, the present reaction is scalable up to one-gram scale. The commercially available palladium on carbon (5 wt%) was used as a heterogeneous catalyst and showed excellent recyclability (5 times) without significant loss in catalytic activity. Pleasingly, under our optimized conditions, the alpha alkyl substituted 2-iodoacetophenones exhibit good diastereoselectivity and predominantly (E)-2-vinylbenzoic acids were obtained with good to excellent yields.

Copper-Catalyzed Amino Lactonization and Amino Oxygenation of Alkenes Using O-Benzoylhydroxylamines

A copper-catalyzed amino lactonization of unsaturated carboxylic acids has been achieved as well as the analogous intermolecular three-component amino oxygenation of olefins. The transformation features mild conditions and a remarkably broad substrate sco

Synthesis of Secondary Unsaturated Lactams via an Aza-Heck Reaction

The preparation of unsaturated secondary lactams via the palladium-catalyzed cyclization of O-phenyl hydroxamates onto a pendent alkene is reported. This method provides rapid access to a broad range of lactams that are widely useful building blocks in alkaloid synthesis. Mechanistic studies support an aza-Heck-type pathway.

A series of two oxidation reactions of ortho-alkenylbenzamide with hypervalent iodine(III): A concise entry into (3 R,4 R)-4-hydroxymellein and (3 R,4 R)-4-hydroxy-6-methoxymellein

A sequence of oxidation reactions of alkenamides with hypervalent iodine is described. Oxidation of ortho-alkenylbenzamide substrates selectively gave isochroman-1-imine products. The products underwent further oxidation in the presence of a Pd salt catal

Supramolecular control of selectivity in hydroformylation of vinyl arenes: Easy access to valuable β-aldehyde intermediates

Go against the flow! A rationally designed regioselective hydroformylation catalyst, [Rh/L], in which noncovalent ligand-substrate interactions allow the unprecedented reversal of selectivity from the typical α-aldehyde to the otherwise unfavored product β-aldehyde, is reported. This catalytic system opens up novel and sustainable synthetic pathways to important intermediates for the fine-chemicals industry.

Regioselective Pd-catalyzed aerobic aza-Wacker cyclization for preparation of isoindolinones and isoquinolin-1(2 H)-ones

A switchable regioselective intramolecular aerobic aza-Wacker cyclization catalyzed by palladium is presented. Isoindolinones or isoquinolin-1(2H)-ones could be prepared selectively from the same substrates using different catalysts. The type and steric hindrance of the ligands may be the variables most significant for regiocontrol.

Selenium-mediated synthesis of biaryls through rearrangement

"Chemical Equation Presented" A new cyclization of β-keto ester substituted stilbene derivatives using selenium electrophiles in the presence of Lewis acids is described. Substituted naphthols are obtained through cyclization and subsequent 1,2-rearrangement of aryl groups under very mild reaction conditions.