32401-36-8

Usage

Uses

Used in Pharmaceutical Industry:
(6-methoxypyridin-3-yl)(phenyl)methanone is used as a key intermediate for the synthesis of various pharmaceuticals. Its unique structure allows for the development of new drugs with potential applications in treating different medical conditions.
Used in Agrochemical Industry:
In the agrochemical sector, (6-methoxypyridin-3-yl)(phenyl)methanone is utilized as a building block for the creation of novel compounds with pesticidal, herbicidal, or fungicidal properties, contributing to the development of more effective and targeted agrochemicals.
Used in Chemical Research:
(6-methoxypyridin-3-yl)(phenyl)methanone serves as an important research tool in the field of organic chemistry, where it is employed in the exploration of new synthetic pathways and the study of reaction mechanisms involving heterocyclic compounds.
Used in Laboratory Settings:
Due to its potential hazardous properties, (6-methoxypyridin-3-yl)(phenyl)methanone is primarily used in laboratory settings by trained professionals for the development and testing of new chemical processes and products.

Upstream product

• 13472-85-0 2-methoxy-5-bromopyridine 
• 98-88-4 benzoyl chloride 
• 41804-83-5 N-phenyl-N-((trifluoromethyl)sulfonyl)benzamide 
• 163105-89-3 2-methoxy-pyridine-5-boronic acid 
• 55-21-0 benzamide 
• 135364-97-5 tert-butyl benzoyl(tert-butoxycarbonyl)carbamate 
• 65-85-0 benzoic acid 
• 5145-65-3 N-benzoylpyrrole 
• 1022094-44-5 5-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)-2-methoxypyridine 
• 858600-08-5 N,6-dimethoxy-N-methylpyridine-3-carboxamide 
• 100-58-3 phenylmagnesium bromide 
• 26218-80-4 6-methoxy-nicotinic acid methyl ester 
• 66572-55-2 6-methoxynicotinic acid 

Relevant academic research and scientific papers

Triflamides: Highly Reactive, Electronically Activated N-Sulfonyl Amides in Catalytic N-C(O) Amide Cross-Coupling

The direct, highly chemoselective Suzuki-Miyaura cross-coupling of trifluoromethanesulfonamides (triflamides) by selective N-C(O) amide bond cleavage is reported. This operationally simple, mild, and user-friendly method accomplishes the direct synthesis of ketones from amides by a catalytic manifold as a powerful alternative to Weinreb amides. Mechanistic studies support rotational inversion and electronic activation, favoring selective insertion under mild conditions. Our data strongly suggest that triflamides should be routinely considered as precursors in amide bond cross-coupling.

General Method for the Suzuki-Miyaura Cross-Coupling of Primary Amide-Derived Electrophiles Enabled by [Pd(NHC)(cin)Cl] at Room Temperature

A general, highly selective method for the room temperature Suzuki-Miyaura cross-coupling of commonly encountered primary benzamides is reported. A combination of site-selective N,N-di-Boc-activation (tert-butoxycarbonyl activation) of the amide nitrogen with practical air- and moisture-stable, well-defined, and highly reactive [Pd(NHC)(cin)Cl] (NHC = N-heterocyclic carbene; cin = cinnamyl) provides a highly effective route to biaryl ketones from primary amides in high yields. For the first time, a TON of >1000 has been achieved in amide acyl cross-coupling.

Ni-Catalyzed cross-coupling reactions of N-acylpyrrole-type amides with organoboron reagents

The catalytic conversion of amides to ketones is highly desirable yet challenging in organic synthesis. We herein report the first Ni/bis-NHC-catalyzed cross-coupling of N-acylpyrrole-type amides with arylboronic esters to obtain diarylketones. This method is facilitated by a new chelating bis-NHC ligand. The reaction tolerates diverse functional groups on both arylamide and arylboronic ester partners including sensitive ester and ketone groups.

Synthesis and reduction reactions of pyridones and 5-acyl-2-methoxypyridines

The synthesis of a series of pyridones, from their 2-hydroxypyridine or 2-methoxypyridine precursors, is described, along with studies into their reductions to saturated heterocycles. A number of 5-acylpyridones were prepared and were evaluated as substrates for asymmetric transfer hydrogenation prior to conversion to saturated heterocycles. The enantioselective reduction of 5-acetyl-1-benzylpyrimidine-2,4(1H,3H)-dione is also described.

Heteroaryl manganese reagents: Direct preparation and reactivity studies

Direct preparation of various heteroaryl manganese reagents was performed by using highly active manganese (Mn*) and heteroaryl halides. The resulting organomanganese reagents were coupled with electrophiles such as aryl halides, vinyl halides, and benzoyl chlorides under mild reaction conditions. The corresponding coupling products were obtained in good yields.