32449-46-0

Upstream product

• 17333-82-3 4-bromo-benzenediazonium ion 
• 2028-85-5 (4-bromophenyl)diazonium chloride 
• 127-09-3 sodium acetate 
• 3425-46-5 potassium selenocyanate 
• 106-40-1 4-bromo-aniline 
• 139139-81-4 bis(4-bromophenyl)iodonium triflate 
• 2179-96-6 triselenium dicyanide 
• 5467-74-3 4-Bromophenylboronic acid 
• 7677-24-9 trimethylsilyl cyanide 

Downstream Products

• 109219-08-1 (4-bromo-phenyl)-(4-chloro-phenyl)-selenide 
• 111355-46-5 biphenyl-4-yl-(4-bromo-phenyl)-selenide 
• 109287-58-3 (4-bromo-phenyl)-m-tolyl selenide 
• 109019-09-2 (4-bromophenyl)(phenyl)selane 
• 20825-08-5 4-bromo-benzeneseleninic acid 
• 20541-48-4 1,2-bis(4-bromophenyl)diselenide 
• 109287-42-5 4-bromophenyl 4-methylphenyl selenide 
• 109512-10-9 (4-bromo-phenyl)-dichloro-phenyl-λ⁴-selane 
• 125715-79-9 biphenyl-4-yl-(4-bromo-phenyl)-dichloro-λ⁴-selane 

Relevant academic research and scientific papers

Bifunctional chiral selenium-containing 1,4-diarylazetidin-2-ones with potent antitumor activities by disrupting tubulin polymerization and inducing reactive oxygen species production

Organoselenium compounds have attracted growing interests as promising antitumor agents over recent years. Herein, four series of novel selenium-containing chiral 1,4-diarylazetidin-2-ones were asymmetrically synthesized and biologically evaluated for ant

Metal-Free Synthesis of Aryl Selenocyanates and Selenaheterocycles with Elemental Selenium

This work reports a green method for the synthesis of aryl selenocyanates via a three-component reaction of arylboronic acids, Se powder, and trimethylsilyl cyanide (TMSCN) under metal-free and additive-free conditions. Remarkably, TMSCN acts as not only the substrate, but also the catalyst. Various selenaheterocycles can be also accessed with a catalytic amount of TMSCN.

Synthesis of Thio-/Selenopyrrolines via SnCl4-Catalyzed (3+2)-Cycloadditions of Donor-Acceptor Cyclopropanes with Thio-/Selenocyanates

A straightforward protocol has been developed to access thio-/selenopyrrolines through a (3+2)-cycloaddition of aryl thio-/selenocyanates with donor-acceptor cyclopropanes (DACs) in the presence of SnCl4 as a Lewis acid catalyst. Further, good chemoselectivity was observed when DACs were treated with 3-cyano phenyl thiocyanate. These results suggest that thiocyanate is more reactive than nitrile moiety in such (3+2)-cycloaddition reactions.

Metal-Free ipso -Selenocyanation of Arylboronic Acids Using Malononitrile and Selenium Dioxide

The first ipso -selenocyanation of arylboronic acids is achieved using selenium dioxide and malononitrile under mild conditions. The reaction is successful even without metal or base in DMSO. The major advantages of this new method are an easy set-up, excellent yields, and the use of odorless and inexpensive selenium reagents. Basic conditions subsequently afford new access to diaryldiselenides in good yields without isolating the organoselenocyanate intermediates.

Synthesis of Monofluoromethyl Selenoethers of Aryl and Alkyl from Organoselenocyanate via One-Pot Reaction

The first practical and feasible approach for the monofluoromethylselenolation of aryl and alkyl halides via one-pot multistep synthesis using KSeCN and ICFH2 is described. Good yields and broad functional group compatibility were obtained. The successful preparation of monofluoromethylselenolated drug-like compounds good practicability of this method. This protocol offered a number of new monofluoromethyl selenoethers, which would accelerate the use of such compounds in the areas of life science. (Figure presented.).

Metal-free synthesis of unsymmetrical organoselenides and selenoglycosides

A one-pot, metal-free procedure has been developed to synthesize unsymmetrical organoselenides. In the first step of the reaction, arylation of potassium selenocyanate (KSeCN) with an iodonium reagent proceeds in the absence of a metal catalyst to produce

Design, Synthesis, and Biological Evaluation of Novel Selenium-Containing Isocombretastatins and Phenstatins as Antitumor Agents

Two series of structurally related organoselenium compounds designed by fusing the anticancer agent methyl(phenyl)selane into the tubulin polymerization inhibitors isocombretastatins or phenstatins were synthesized and evaluated for antiproliferative acti

Synthesis of novel 5-aryl-1H-tetrazoles

In this study phenylselenocyanate and some of its derivatives (o-Cl, p-Cl, p-Br, o-NO2, p-NO2, o-CH3, p-CH3, o-COOH, p-COOH, p-OCH3 substituted) were synthesized (3a-3j). The synthesized compounds were converted to 5-aryl-1H-tetrazole (4a-4j), by Et 3N · HCl-NaN3 in toluene, which are a new series of phenylselanyl-1H-tetrazoles. The structure of all the presently synthesized compounds were confirmed using spectroscopic methods (FTIR, 1H NMR, MS).