32479-73-5

Usage

Uses

Used in Chemical Synthesis:
1,3-Diethylbarbituric Acid is used as a reactant/reagent in the green preparation of spiropyran derivatives. This process involves a three-component cyclization of indantrione with active methylene compounds and cyclic diketones, facilitated by the presence of a compact fluorescent lamp. This method is considered environmentally friendly and efficient, making it a valuable application in the field of organic chemistry.
Used in Photochemistry:
The use of 1,3-Diethylbarbituric Acid in the synthesis of spiropyran derivatives highlights its potential role in photochemistry. Spiropyran compounds are known for their photochromic properties, which can be useful in various applications such as optical data storage, molecular switches, and sensors.
Used in Pharmaceutical Industry:
Although not explicitly mentioned in the provided materials, the unique structure and reactivity of 1,3-Diethylbarbituric Acid may also suggest potential applications in the pharmaceutical industry. Its ability to participate in cyclization reactions could make it a valuable building block for the development of new drugs or drug delivery systems.

InChI:InChI=1/C8H12N2O3/c1-3-9-6(11)5-7(12)10(4-2)8(9)13/h3-5H2,1-2H3

Upstream product

• 102-09-0 bis(phenyl) carbonate 
• 63884-60-6 N,N'-bis-ethoxycarbonyl-2,2-diethyl-malonic acid diamide 
• 57-13-6 urea 
• 108-19-0 BIURET 
• 54505-72-5 diethylmalonyl chloride 
• 141-82-2 malonic acid 
• 693-29-8 N,N'-diethylcarbodiimide 
• 1663-67-8 malonoyl dichloride 
• 7664-93-9 sulfuric acid 
• 96-31-1 N,N'-Dimethylurea 
• 623-76-7 N,N'-diethylurea 

Downstream Products

• 115725-78-5 1,3-diethyl-5-[(1,3,3-trimethyl-indolin-2-yliden)-ethylidene]-barbituric acid 
• 86872-79-9 1,3-diethyl-5-(4-dimethylamino-benzylidene)-barbituric acid 
• 37042-04-9 1,3-diethyl-5-(4-oxo-2-phenyl-4H-chromen-3-ylmethylene)-pyrimidine-2,4,6-trione 
• 110-62-3 pentanal 
• 65150-41-6 6-chloro-1,3-diethyluracil 
• 37042-08-3 1,3-diethyl-5-(4-oxo-2-phenyl-4H-chromen-3-ylmethyl)-pyrimidine-2,4,6-trione 
• 1135372-41-6 5,5-bis(2-bromobenzyl)-1,3-diethylbarbituric acid 
• 1207614-77-4 5,7-diethyl-4,6,8-trioxo-2-phenyl-5,7-diazaspiro[2.5]octane-1,1-dicarbonitrile 
• 1207614-78-5 5,7-diethyl-2-(4-methylphenyl)-4,6,8-trioxo-5,7-diazaspiro[2.5]octane-1,1-dicarbonitrile 
• 1207614-79-6 2-(4-chlorophenyl)-5,7-diethyl-4,6,8-trioxo-5,7-diazaspiro[2.5]octane-1,1-dicarbonitrile 
• 1248591-27-6 C₂₄H₂₇N₅O₅ 
• 1248591-29-8 C₂₅H₂₉N₅O₅ 
• 1251930-83-2 5-(4-chlorophenyl)-1,3-diethyl-2-thioxo-2,3,8,9-tetrahydro-1H-chromeno[2,3-d]pyrimidine-4,6(5H,7H)-dione 
• 1251930-80-9 5-(4-chlorophenyl)-1,3-diethyl-8,8-dimethyl-2-thioxo-2,3,8,9-tetrahydro-1H-chromeno[2,3-d]pyrimidine-4,6(5H,7H)-dione 

Relevant academic research and scientific papers

Thermophysical study of several barbituric acid derivatives by differential scanning calorimetry (DSC)

The present study reports a differential scanning calorimetry (DSC) study of the barbituric acid derivatives: 1,3-dimethylbarbituric acid [CAS 769-42-6], 5,5-dimethylbarbituric acid [CAS 24448-94-0], 1,3-diethylbarbituric acid [CAS 32479-73-5], 1,3,5-trimethylbarbituric acid [CAS 7358-61-4], 1,5,5-trimethylbarbituric acid [CAS 702-47-6], and tetramethylbarbituric acid [CAS 13566-66-0] in the temperature interval from T = 268 K to their respective melting temperatures. Temperatures, enthalpies and entropies of fusion, and the heat capacities of the solid compounds as a function of temperature are reported.

Compound with aggregation-induced emission property, and application thereof in field of surgical navigation

The invention belongs to the technical field of synthesis of compounds with aggregation-induced emission properties, and relates to a compound with an aggregation-induced emission property, and application thereof. The compound has the beneficial effects that 1, a new thought of surgical navigation is provided; 2, materials are easy to obtain, cost is low, and preparation is easy; 3, the biotoxicity is low; and 4, the luminescent wavelength is long, the interference of background fluorescence is small, and the tissue penetrability is strong.

Selective Inhibitors of a Human Prolyl Hydroxylase (OGFOD1) Involved in Ribosomal Decoding

Human prolyl hydroxylases are involved in the modification of transcription factors, procollagen, and ribosomal proteins, and are current medicinal chemistry targets. To date, there are few reports on inhibitors selective for the different types of prolyl hydroxylases. We report a structurally informed template-based strategy for the development of inhibitors selective for the human ribosomal prolyl hydroxylase OGFOD1. These inhibitors did not target the other human oxygenases tested, including the structurally similar hypoxia-inducible transcription factor prolyl hydroxylase, PHD2.

Reaction of 1,3-Dialkylbarbituric acids with aliphatic amines

On heating triethylammonium 1,3-dimethylbarbiturate, 1,3-dimethylthiobarbiturate, and 1,3-diphenylbarbiturate occurs dealkylation of triethylamine to afford in high yields the corresponding 5-ethyl substituted barbituric acids. The cleavage of alkyl groups happened also efficiently with tributyl, tribenzyl, and dimethylbenzylammonium salts, and less efficiently with trimethylammonium and diethylammonium salts. These reactions are characteristic only of 1.3-disubstituted barbituric acids; the barbituric acid and its 1-alkyl derivatives under these conditions suffer degradation.

A facile entry to fused pyrimidines: Preparation of pyrimido[4,5-b]quinoline and pyrido[2,3-d:6,5-d']dipyrimidine derivatives

A number of pyrimido[4,5-b]quinolines 3 and pyrido[2,3-d:6,5-d']-dipyrimidines have been prepared by reaction of N,N'-disubstituted barbituric acids with the iminophosphorane derived from o-azidobenzaldehyde or 6-amino-5-formyl-1,3-dimethyluracil.