325796-84-7Relevant academic research and scientific papers
An investigation of structure‐activity relationships of azolylacryloyl derivatives yielded potent and long‐acting hemoglobin modulators for reversing erythrocyte sickling
Abdulmalik, Osheiza,El‐araby, Moustafa E.,Ghatge, Mohini S.,Muhammad, Yosra A.,Omar, Abdelsattar M.,Paredes, Steven D.,Safo, Martin K.
, p. 1 - 21 (2020/11/09)
Aromatic aldehydes that bind to sickle hemoglobin (HbS) to increase the protein oxygen affinity and/or directly inhibit HbS polymer formation to prevent the pathological hypoxia‐induced HbS polymerization and the subsequent erythrocyte sickling have for s
Discovery of oxazolobenzimidazoles as positive allosteric modulators for the mGluR2 receptor
Garbaccio, Robert M.,Brnardic, Edward J.,Fraley, Mark E.,Hartman, George D.,Hutson, Pete H.,O'Brien, Julie A.,Magliaro, Brian C.,Uslaner, Jason M.,Huszar, Sarah L.,Fillgrove, Kerry L.,Small, James H.,Tang, Cuyue,Kuo, Yuhsin,Jacobson, Marlene A.
scheme or table, p. 406 - 410 (2011/02/21)
Novel oxazolobenzimidazoles are described as potent and selective positive allosteric modulators of the metabotropic glutamate receptor 2. The discovery of this class and optimization of its physical and pharmacokinetic properties led to the identificatio
PYRAZOLE DERIVATIVE
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Page/Page column 32, (2010/11/27)
A compound represented by Formula (I): wherein Ar1 represents Formula (II): Ar2 represents a 5- or 6-membered aromatic heterocyclic group which may be substituted; and X represents Formula (III): a salt thereof, or a solvate of the compound or the salt. A potent platelet aggregation suppressant which does not inhibit COX-1 and COX-2 is provided.
Thieno-pyrimidine compounds having fungicidal activity
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Page/Page column 33-34, (2010/11/08)
The present invention relates to thieno[2,3-d]-pyrimidine compounds having fungicidal activity.
Intramolecular alkylation of aromatic compounds, XXXIV: Synthesis of pyridinylmethyl indolines as potential precursors of ergolines
Reimann,Erdle
, p. 907 - 912 (2007/10/03)
The carbinoles 3 prepared from the N-protected indolaldehydes 2 and bromomethoxypyridine 1 can smoothly be hydrogenolized to the lutidinylindoles 4 which in turn give the corresponding indolines 5 by NaCNBH3-reduction. Treatment of 3a by acid the trihetarylmethane 9 and 5-methoxypyridine-2-carboxaldehyde 10 are generated. The acetylpyridine 7 is found as a by-product of 3c. As by-product of the reduction the borane adduct 8 is detected.
