32588-36-6

Basic information

• Product Name: INDOLE-2-ACETIC ACID
• Synonyms: 1H-INDOLE-2-ACETIC ACID;(1H-INDOL-2-YL)-ACETIC ACID;1h-indole-2-acetic acid (as sodium salt);2-(2-indolyl)acetic acid 4-nitrophenyl ester;2-Indolylacetic acid;INDOLE-2-ACETIC ACID
• CAS NO: 32588-36-6
• Molecular Formula: C₁₀H₉NO₂
• Molecular Weight: 175.18
• Product Categories: Carboxylic Acids;Pyrroles & Indoles;Carboxylic Acids;Pyrroles & Indoles;Heterocycles
• Mol File: 32588-36-6.mol
• Article Data: 7

Chemical Properties

• Melting Point: 95℃ (DEC.)
• Boiling Point: 415.03 °C at 760 mmHg
• Flash Point: 204.803 °C
• Appearance: /
• Density: 1.354
• Vapor Pressure: 1.24E-07mmHg at 25°C
• Refractive Index: 1.693
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
• PKA: 4.54±0.30(Predicted)
• CAS DataBase Reference: INDOLE-2-ACETIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: INDOLE-2-ACETIC ACID(32588-36-6)
• EPA Substance Registry System: INDOLE-2-ACETIC ACID(32588-36-6)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 32588-36-6(Hazardous Substances Data)

Usage

Chemical Properties

off-white powder

InChI:InChI=1/C10H9NO2/c12-10(13)6-8-5-7-3-1-2-4-9(7)11-8/h1-5,11H,6H2,(H,12,13)

Upstream product

• 914362-38-2 2-Carboxymethyl-indole-1-carboxylic acid 
• 7210-27-7 2-indoleacetonitrile 
• 19005-93-7 1H-indol-2-ylcarboxaldehyde 
• 1643439-37-5 methyl 2‐(1‐(pyrimidin‐2‐yl)‐1H‐indol‐2‐yl)acetate 
• 40899-71-6 1-benzenesulfonylindole 
• 120-72-9 indole 
• 75400-66-7 N-(phenylsulfonyl)-2-methoxalylindole 
• 21422-40-2 methyl 1H-indole-2-acetate 
• 108629-63-6 2-indol-2-yl-acetimidic acid ethyl ester; hydrochloride 
• 66073-33-4 4-(2-nitrophenyl)-3-oxobutyric acid ethyl ester 
• 61417-33-2 ethyl 2-acetyl-3-oxo-4-(2-nitrophenyl)butanoate 
• 95-20-5 2-methyl-1H-indole 
• 1477-50-5 Indole-2-carboxylic acid 
• 24621-70-3 2-(hydroxymethyl)indole 

Downstream Products

• 21422-40-2 methyl 1H-indole-2-acetate 
• 91677-71-3 [3-(1-Pyridin-3-yl-ethyl)-1H-indol-2-yl]-acetic acid methyl ester 
• 91653-17-7 2,11-Dimethyl-4a,5,6,11-tetrahydro-2H-pyrido[4,3-b]carbazole-5-carboxylic acid methyl ester 
• 91653-14-4 1-<2-(carbomethoxymethyl)-3-indolyl>-1-(3-pyridyl)ethene 
• 1352569-53-9 ethyl 2-(1-(2-(1H-indol-2-yl)acetyl)indolin-2-yl)acetate 
• 616235-64-4 C₂₆H₃₂N₄ 

Relevant articles and documents

Rh-Catalyzed C-H bond alkylation of indoles with α,α-difluorovinyl tosylate: Via indolyl group migration

Herein we demonstrate that an alkylation of indoles could be accessed through C-H bond functionalization with α,α-difluorovinyl tosylate. The key aspect for the effective alkylation is the influence of the fluorine substituents on the reactivity of the CC double bond, allowing regioselective insertion as well as an indolyl group shift process. Furthermore, the fluorides are removed through alcoholysis to furnish the alkylation product as a traceless auxiliary.

6,7,14,15-Tetrahydro-15aH-azocino[1,2-a:6,5-b′]diindole. Synthesis of a novel pentacyclic ring system

In search of new lead structures for potent allosteric enhancers of antagonist binding to muscarinic M2 receptors, a novel heterocyclic ring system, 6,7,14,15-tetrahydro-15aH-azocino[1,2-a:6,5-b′]diindole, has been synthesized. The new ring skeleton was obtained from indol-2-yl-acetic acid in three steps.

INDOLE DERIVATIVES AS DOPAMINE D4 ANTAGONISTS

Compound of formula (I), or a pharmaceutically acceptable salt thereof or a prodrug thereof wherein E represents--CH 2--or--CH. sub.2 CH. sub. 2--; R represents hydrogen or C 1-6 alkyl; Q represents a moiety of formula Qa, Qb, Qc or Qd which are antagonists of dopamine receptor subtypes within the brain, having a selective affinity for the dopamine D. sub.4 receptor subtype over other dopamine receptor subtypes, and are accordingly of benefit in the treatment and/or prevention of psychotic disorders such as schizophrenia whilst manifesting fewer side-effects than those associated with classical neuroleptic drugs. STR1