4987-96-6

Usage

Uses

Used in Dye Production:
4,6-Dinitrobenzene-1,3-diamine is used as a chemical intermediate for the production of dyes. Its unique structure allows for the creation of various dye compounds that are utilized in different industries for coloring textiles, plastics, and other materials.
Used in Pharmaceutical Industry:
In the pharmaceutical sector, 4,6-dinitrobenzene-1,3-diamine is used as a key component in the synthesis of certain drugs. Its reactivity and functional groups facilitate the development of pharmaceutical compounds with specific therapeutic properties.
Used in Organic Compounds Synthesis:
4,6-dinitrobenzene-1,3-diamine is also utilized as a precursor in the synthesis of other organic compounds, contributing to the chemical diversity and innovation in various chemical industries.
Used in Explosives Production:
Due to its chemical composition, 4,6-dinitrobenzene-1,3-diamine is used in the production of explosives. Its properties make it a suitable component for the formulation of certain types of explosives.
Safety Note:
Given its toxic and mutagenic effects, 4,6-dinitrobenzene-1,3-diamine requires careful handling and the implementation of proper safety measures to mitigate potential health and environmental risks.

InChI:InChI=1/C6H6N4O4/c7-3-1-4(8)6(10(13)14)2-5(3)9(11)12/h1-2H,7-8H2

Upstream product

• 24239-82-5 1,5-dibromo-2,4-dinitrobenzene 
• 89464-07-3 2,4,5-trinitrobromobenzene 
• 64-17-5 ethanol 
• 861592-96-3 1,5-bis-(1-hydroxy-1H-[2]isoquinolyl)-2,4-dinitro-benzene 
• 62-53-3 aniline 
• 3698-83-7 2,4-dichloro-1,5-dinitrobenzene 
• 7664-41-7 ammonia 
• 1210-96-4 1,3-dimethoxy-4,6-dinitrobenzene 
• 327-92-4 1,5-difluoro-2,4-dinitrobenzene 
• 367-82-8 3-Fluoro-4,6-dinitrophenol 
• 446-35-5 2,4-Difluoronitrobenzene 
• 541-73-1 1,3-Dichlorobenzene 
• 446-36-6 5-fluoro-2-nitrophenol 
• 20039-27-4 N-acetyl-2,4-dinitro-5-chloroaniline 

Downstream Products

• 3204-61-3 1,2,4,5-tetraaminobenzene 
• 6635-35-4 1,2,4-triamino-5-nitro-benzene 
• 117899-09-9 N,N'-(4,6-diamino-m-phenylene)-bis-amidosulfuric acid ; disodium-salt 
• 42783-40-4 1,5-bis(acetylamino)-2,4-dinitrobenzene 
• 67451-30-3 N-[5-(Ethoxyoxalyl-amino)-2,4-dinitro-phenyl]-oxalamic acid ethyl ester 
• 1233335-55-1 tert-butyl tert-butoxycarbonyl(5-((tert-butoxycarbonyl)amino)-2,4-dinitrophenyl)carbamate 
• 1233335-54-0 di-tert-butyl (4,6-dinitro-1,3-phenylene)bis(tert-butoxycarbonylcarbamate) 
• 4506-66-5 1,2,4,5-benzenetetraamine tetrahydrochloride 

Relevant academic research and scientific papers

Process for the preparation of derivatives of tetraaminobenzene

A process is provided for preparing complexes of 1,2,4,5-tetraminobenzene with an aromatic diacid. The process design eliminates costly intermediate drying and recrystallization steps. Handling of solid materials with possible skin sensitizing properties and toxicity is avoided, thereby eliminating human and environmental exposure.

2,4,5-TRIAMINOTHIOPHENOLS AND RELATED COMPOUNDS

New triaminothiophenol compositions and related compounds are disclosed, as are processes for their preparation and for the preparation of novel salts, diacid complexes, and polymers from such compounds. Polymers prepared from these compositions can be made into high strength fiber, film, and tape and are useful in applications such as protective apparel, aircraft, automotive components, personal electronics, and sports equipment.

INTEGRATED PROCESSES FOR THE PREPARATION OF HETEROCYCLIC AROMATIC POLYMER PRECURSORS

An integrated process is provided for efficiently preparing 2, 4, 5-triaminothiophenol, starting; high purity salts thereof; and complexes of 2, 4, 5-triaminothiophenol with aromatic diacids, which are precursors for making polymer for high performance fibers. The process design eliminates several costly intermediate drying and recrystallization steps. The handling of solid materials with possible skin sensitizing properties and toxicity is avoided, thereby eliminating human and environmental exposure.

2,4,5-TRIAMINOTHIOPHENOLS AND RELATED COMPOUNDS

New triaminothiophenol compositions and related compounds are disclosed, as are processes for their preparation and for the preparation of novel salts and diacid complexes from such compounds. Polymers prepared from these compositions can be made into high strength fiber, film, and tape and are useful in applications such as protective apparel, aircraft, automotive components, personal electronics, and sports equipment.

Process for the synthesis of 1,3-diamino-4,6-dinitrobenzene

A process is provided for the preparation of 1,3-diamino-4,6-dinitrobenzene by amination of 1,3-dihalo-4,6-dinitrobenzene. The presence of water advantageously results in a highly pure product, free or essentially free of glycol ether impurities.

Efficient total synthesis of ammosamide B

A total synthesis of ammosamide B, a metabolite of the marine-derived Streptomyces strain CNR-698, has been executed in nine steps and 6.9% overall yield. The key step involves the condensation of a 4,6-diBoc-protected 1,3,4,6-tetraaminobenzene derivative with dimethyl 2-ketoglutaconate, which effectively constructs the pyrrolidinone ring and the quinoline ring in a single step. This contributes a unique approach to the synthesis of pyrroloquinoline alkaloids that offers the advantages of brevity and relatively high overall yield.

Synthesis of 1,5-Diamino-1,5-dihydrobenzobistriazole (DABT) and Its Use as a 1,4-Benzadiyne Equivalent

Amination of 1,5-dihydrobenzobistriazole (9) gives the 1,5- and 1,7-diamino derivatives 3 and 10 both useful as 1,4-benzadiyne equivalents, as well as the 1,6 isomer 11 and the recyclable monoamino derivatives 12 and 13.Sixteen examples of the synthetic utility of DABT (3) with lead tetraacetate in bisannulations are described (Table 1).The aryne-trapping dienes include ester, halogen, and carbonyl functionality; often the reactions are quite regio- and stereoselective as a consequence of the stepwise nature of the annulations.

Chemotherapeutically active nitro compounds. I. Nitroanilines

More than 200 nitro compounds, most of them nitroaniline derivatives substituted with one or more radicals having a basic reaction, were prepared and investigated as to their therapeutic activity against bacteria, fungi, protozoa, helminths, viruses and tumors. Several mono nitrobenzenes with a radical having a basic reaction showed a weak in vitro activity against gram positive bacteria and against Crocker's sarcoma 180; they also showed systemic activity against nematodes (Aspiculuris tetraptera) and viruses. The majority of therapeutically active compounds with pronounced in vitro activity against Trichomonas fetus, Entamoeba histolytica, Schistosoma mansoni, cestodes, nematodes (Ancylostoma caninum), viruses (influenza, MHV, SAV and EMC) and various types of carcinoma (Ehrlich's carcinoma, leukemia 1210, Crocker's sarcoma 180) were dinitrobenzene derivatives with one radical having a basic reaction and electropositive groups or unreactive or reactive chlorine atom, and di nitrobenzene with two equal or two different radicals having a basic reaction. Compound No. 70 revealed a marked in vitro activity against fungi (Trichophyton; Microsporum, Candida albicans). Other nitro compounds such as bis mono and bis dinitrobenzene derivatives likewise showed a systemic action against E. histolytica, viruses and, in particular, carcinoma (Crocker's sarcoma 180, Ridgway's osteosarcoma). Oxygen and sulfur analogue compounds as well as compounds produced by reduction also possessed a distinct activity against E. histolytica and viruses. On the basis of the present results, the dinitrobenzenes substituted with two radicals having a basic reaction include a number which have in common a recognizable structure/activity relationship in respect to E. histolytica, Schistosoma mansoni and different types of viruses. The activity against viruses in this class of compounds is probably due to an increased interferon production in the host animal. Whether the mechanism of action is the same against E. histolytica or Schistosoma mansoni has not been determined so far. A tumorigenic effect was observed mainly in those di nitrobenzenes which are classed as alkylating compounds. Because of the small chemotherapeutic index, the trials were not continued with the most effective compounds mentioned.