148854-10-8

Basic information

• Product Name: (2,4-DIFLUOROPHENYL)TRIMETHYLSILANE
• Synonyms: (2,4-DIFLUOROPHENYL)TRIMETHYLSILANE
• CAS NO: 148854-10-8
• Molecular Weight: 186.277
• Mol File: 148854-10-8.mol

Chemical Properties

• CAS DataBase Reference: (2,4-DIFLUOROPHENYL)TRIMETHYLSILANE(CAS DataBase Reference)
• NIST Chemistry Reference: (2,4-DIFLUOROPHENYL)TRIMETHYLSILANE(148854-10-8)
• EPA Substance Registry System: (2,4-DIFLUOROPHENYL)TRIMETHYLSILANE(148854-10-8)

Safety Data

• Hazardous Substances Data: 148854-10-8(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
(2,4-DIFLUOROPHENYL)TRIMETHYLSILANE is used as a reagent in organic synthesis for its ability to facilitate various chemical reactions and improve the efficiency of the synthesis process.
Used in Pharmaceutical Production:
In the pharmaceutical industry, (2,4-DIFLUOROPHENYL)TRIMETHYLSILANE is used as a building block for the production of various pharmaceuticals. Its unique structure allows it to be incorporated into the molecular design of new drugs, potentially enhancing their efficacy and selectivity.
Used in Agrochemical Production:
(2,4-DIFLUOROPHENYL)TRIMETHYLSILANE is also utilized in the agrochemical industry as a building block for the development of new agrochemicals. Its incorporation into these compounds can lead to improved performance and selectivity in agricultural applications.
Used in Fine Chemicals Production:
(2,4-DIFLUOROPHENYL)TRIMETHYLSILANE is used in the synthesis of various fine chemicals, where its unique properties can contribute to the development of high-quality specialty chemicals for a range of applications.
Used in Organic Silicon Compounds Synthesis:
(2,4-DIFLUOROPHENYL)TRIMETHYLSILANE is employed in the synthesis of organic silicon compounds, which have a wide range of applications in various industries, including electronics, materials science, and chemical manufacturing.

Upstream product

• 75-77-4 chloro-trimethyl-silane 
• 348-57-2 2,4-difluorobromobenzene 
• 1450-14-2 1,1,1,2,2,2-hexamethyldisilane 

Downstream Products

• 22494-42-4 2',4'-difluoro-4-hydroxybiphenyl-3-carboxylic acid 
• 219926-39-3 3-Bromo-2,6-difluorophenyltrimethylsilane 
• 219926-41-7 1,3-Dibromo-2,4-difluorobenzene 
• 372-18-9 1,3-Difluorobenzene 
• 446-35-5 2,4-Difluoronitrobenzene 
• 367-82-8 3-Fluoro-4,6-dinitrophenol 
• 327-92-4 1,5-difluoro-2,4-dinitrobenzene 
• 348-57-2 2,4-difluorobromobenzene 
• 367-23-7 1,2,4-trifluorobenzene 

Relevant articles and documents

Synthese d'aryl- et heteroarylsilanes par scission de l'hexamethyldisilane

In the presence of hexamethylphosphormaide and a catalytic quantity of tetrakis(triphenylphosphine)palladium, hexamethyldisilane reacts with various functional aryl bromides to give the corresponding arylsilanes in satisfactory yields.The reaction has bee

Remote trimethylsilyl groups interfering with the ortho deprotonation of fluoroarenes and chloroarenes

(2-Fluorophenyl)trimethylsilane (2-F) and (2-chlorophenyl)-trimethylsilane (2-Cl) react with sec-butyllithium or lithium 2,2,6,6-tetramethylpiperidide under permutational hydrogen/metal interconversion (metalation) more slowly than, respectively, the corr

Fluorodesilylations of fluorophenyltrimethylsilanes with elemental fluorine: Discovery of a novel 1,2-migration of the trimethylsilyl group

The main product in the direct elemental fluorination of 4-fluorophenyltrimethylsilane was 1,4-difluorobenzene, produced by the ipso electrophilic substitution of the trimethylsilyl group. An unexpected product, 2,5-difluorophenyltrimethylsilane, was also formed as the result of a novel 1,2-migration of the trimethylsilyl group. The same trimethylsilyl 1,2-shifts were observed in the elemental fluorinations of 2-fluoro-and 2,4-difluoro-phenyltrimethylsilanes. We propose that the carbocations formed in the rearrangements were stabilised by the mescineric effect of the α-fluorine and the greater stability of these intermediates provided the driving force for the trimethylsilyl group migrations. Although the main products in all of the fluorinations were the fluorodesilylated product, the reactions were not totally regioselective and some competing fluorodeprotonation also occurred in the reactions of 2-fluoro-and 2,4-difluoro-phenyltrimethylsilanes. The role of protic acids and Lewis acids in particular triflic acid, trifluoroacetic acid and boron trifluoride in a variety of co-solvents, respectively, was crucial in all the fluorinations we studied, experiments done in their absence gave very poor yields. Optimal conditions for fluorination of silylated substrates are described.

Synthetic applications of fluorinated phenyllithiums: Preparation of fluorinated α-methylstyrenes, benzhydrols, benzophenones and aryltrimethylsilanes

Regioselective preparations of a number of fluorinated phenyllithiums have recently been reported, which in some cases also contain one or more bromine substituents. These have now been applied to the synthesis of the corresponding halogenated 2-arylpropenes (α-methyl-styrenes), benzhydrols, trifluoromethylbenzhydrols, benzophenones and aryltrimethylsilanes.