32897-60-2Relevant academic research and scientific papers
Enantioselective NiH/Pmrox-Catalyzed 1,2-Reduction of α,β-Unsaturated Ketones
Chen, Fenglin,Zhang, Yao,Yu, Lei,Zhu, Shaolin
supporting information, p. 2022 - 2025 (2017/02/15)
The enantioselective 1,2-reduction of α,β-unsaturated ketones was achieved using a NiH catalyst in the presence of pinacolborane. This mild process represents a general method to access a wide variety of structurally diverse α-chiral allylic alcohols in excellent yields and enantioselectivity, as well as very high levels of ambidoselectivity for 1,2- over 1,4-reduction. Furthermore, for reactions on a 10 mmol scale, catalyst loadings as low as 0.5 mol % could be employed to deliver product without any detrimental effect on the yield, enantio-, or ambidoselectivity.
Br?nsted Acid Catalyzed Homoconjugate Addition of Organotrifluoroborates to Arylated Cyclopropyl Ketones
Nguyen, Truong N.,Nguyen, Thien S.,May, Jeremy A.
supporting information, p. 3786 - 3789 (2016/08/16)
A novel and practical homoconjugate addition of alkenyl, alkynyl, heteroaryl, and aryl trifluoroborates to arylated cyclopropyl ketones to synthesize γ,γ-disubstituted ketones is reported. A preliminary mechanistic proposal involving ketone protonation, a
New nucleotide-competitive non-nucleoside inhibitors of terminal deoxynucleotidyl transferase: Discovery, characterization, and crystal structure in complex with the target
Costi, Roberta,Cuzzucoli Crucitti, Giuliana,Pescatori, Luca,Messore, Antonella,Scipione, Luigi,Tortorella, Silvano,Amoroso, Alessandra,Crespan, Emmanuele,Campiglia, Pietro,Maresca, Bruno,Porta, Amalia,Granata, Ilaria,Novellino, Ettore,Gouge, Jéro?me,Delarue, Marc,Maga, Giovanni,Di Santo, Roberto
supporting information, p. 7431 - 7441 (2013/10/21)
Terminal deoxynucletidyl transferase (TdT) is overexpressed in some cancer types, where it might compete with pol μ during the mutagenic repair of double strand breaks (DSBs) through the nonhomologous end joining (NHEJ) pathway. Here we report the discove
DIRECT REGIOSELECTIVE VINYLATION OF INDOLES USING PALLADIUM (II) CHLORIDE
Murakami, Yasuoki,Yokoyama, Yuusaku,Aoki, Tsuyoshi
, p. 1493 - 1496 (2007/10/02)
Direct regioselective vinylation at C3-position of ethyl indole-2-carboxylate, its N-benzyl derivative, and N-benzylindole with various conjugated olefins was accomplished in the presence of palladium (II) chloride and acetate salt in good to moderate yie
