329-17-9

Basic information

• Product Name: Benzenamine, N,N-dimethyl-4-(trifluoromethyl)-
• CAS NO: 329-17-9
• Molecular Formula: C9H10F3N
• Molecular Weight: 189.18
• Mol File: 329-17-9.mol
• Article Data: 40

Chemical Properties

• CAS DataBase Reference: Benzenamine, N,N-dimethyl-4-(trifluoromethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenamine, N,N-dimethyl-4-(trifluoromethyl)-(329-17-9)
• EPA Substance Registry System: Benzenamine, N,N-dimethyl-4-(trifluoromethyl)-(329-17-9)

Safety Data

• Hazardous Substances Data: 329-17-9(Hazardous Substances Data)

Upstream product

• 455-14-1 4-trifluoromethylphenylamine 
• 74-88-4 methyl iodide 
• 50-00-0 formaldehyd 
• 55642-42-7 bis(trifluoromethyl)tellurium 
• 121-69-7 N,N-dimethyl-aniline 
• 402-43-7 p-trifluoromethylphenyl bromide 
• 67530-30-7 N,N-dimethyl O-(2,4,6-trimethylphenyl-sulfonyl) hydroxylamine 
• 1092380-21-6 S-(trifluoromethyl)-4-nitrophenylphenylsulfonium tetrafluoroborate 
• 1226-46-6 thiomichlersketone 
• 1092380-24-9 S-(trifluoromethyl)-4-nitrophenylphenylsulfonium triflate 
• 67-68-5 dimethyl sulfoxide 
• 1622092-08-3 2,4-dimethyl-7-(pentafluorosulfanyl)-5-(trifluoromethyl)dibenzo[b,d]thiophenium trifluoromethanesulfonate 
• 124-38-9 carbon dioxide 
• 506-59-2 N,N-dimethylammonium chloride 

Downstream Products

• 22864-65-9 N-methyl-4-(trifluoromethyl)aniline 
• 1369856-62-1 2-bromo-N,N-dimethyl-4-(trifluoromethyl)aniline 
• 214360-65-3 4-trifluoromethylphenylboronic acid pinacol ester 
• 74702-40-2 N-(4-(trifluoromethyl)phenyl)formamide 
• 91385-14-7 N-methyl-N-(4-(trifluoromethyl)phenyl)nitrous amide 
• 402-54-0 p-nitrobenzotrifluoride 
• 27389-56-6 N,N,N-trimethyl-4-(trifluoromethyl)benzenaminium iodide 

Relevant articles and documents

Visible-Light-Mediated Late-Stage Sulfonylation of Anilines with Sulfonamides

A visible-light-mediated late-stage sulfonylation of anilines with sulfonamides under simple reaction conditions is presented. Various primary or secondary sulfonamides including several pharmaceuticals were incorporated successfully via N–S bond activati

Aminomethylation of Aryl Bromides by Nickel-Catalyzed Electrochemical Redox Neutral Cross Coupling

We develop an electrochemical nickel-catalyzed aminomethylation of aryl bromides under mild conditions. The convergent paired electrolysis makes full use of anode and cathode processes, free of a terminal oxidant, a sacrificial anode, a metal reductant, and a prefunctionalized radical precursor. In addition, this method exhibits wide functional group tolerance (63 examples), including some sensitive substituents and aromatic heterocycles. This redox neutral cross coupling provides a more environmentally friendly and synthetic practical protocol for forging C(sp2)–C(sp3) bonds.

Mechanistic Insight into Copper-Mediated Trifluoromethylation of Aryl Halides: The Role of CuI

The synthesis, characterization, and reactivity of key intermediates [Cu(CF3)(X)]-Q+ (X = CF3 or I, Q = PPh4) in copper-mediated trifluoromethylation of aryl halides were studied. Qualitative and quantitative studies showed [Cu(CF3)2]-Q+ and [Cu(CF3)(I)]-Q+ were not highly reactive. Instead, a much more reactive species, ligandless [CuCF3] or DMF-ligated species [(DMF)CuCF3], was generated in the presence of excess CuI. On the basis of these results, a general mechanistic map for CuI-promoted trifluoromethylation of aryl halides was proposed. Furthermore, on the basis of this mechanistic understanding, a HOAc-promoted protocol for trifluoromethylation of aryl halides with [Ph4P]+[Cu(CF3)2]- was developed.