32960-45-5

Basic information

• Product Name: 1-(4-methoxyphenyl)cycloheptene
• CAS NO: 32960-45-5
• Molecular Formula: C₁₄H₁₈O
• Molecular Weight: 202.2921
• Mol File: 32960-45-5.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 306.7°C at 760 mmHg
• Flash Point: 119.7°C
• Density: 0.993g/cm³
• Vapor Pressure: 0.00137mmHg at 25°C
• Refractive Index: 1.53
• CAS DataBase Reference: 1-(4-methoxyphenyl)cycloheptene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-methoxyphenyl)cycloheptene(32960-45-5)
• EPA Substance Registry System: 1-(4-methoxyphenyl)cycloheptene(32960-45-5)

Safety Data

• Hazardous Substances Data: 32960-45-5(Hazardous Substances Data)

Usage

General Description

1-(4-methoxyphenyl)cycloheptene, also known as 4-methoxycycloheptene-1-phenyl, is a chemical compound with the molecular formula C14H16O. It is a cycloheptene derivative with a methoxy group attached to the phenyl ring. 1-(4-methoxyphenyl)cycloheptene is commonly used in the synthesis of pharmaceuticals and as a building block in organic chemistry. It has also been studied for its potential pharmacological properties, including its ability to act as a potential anti-inflammatory and analgesic agent. Additionally, 1-(4-methoxyphenyl)cycloheptene has been investigated for its potential use in the development of new materials and as a tool in organic synthesis due to its unique structural properties. Overall, this chemical compound has a diverse range of potential applications in various industries.

Upstream product

• 28075-51-6 cyclohept-1-en-1-yl trifluoromethanesulfonate 
• 100-66-3 methoxybenzene 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 502-42-1 cycloheptanone 
• 628-92-2 Cycloheptene 
• 66107-29-7 4-methoxyphenyl triflate 
• 150-76-5 4-methoxy-phenol 
• 77826-30-3 1-(4-methoxyphenyl)cycloheptan-1-ol 
• 13139-86-1 4-methoxyphenyl magnesium bromide 

Downstream Products

• 75120-08-0 4-cycloheptylphenol 
• 16235-49-7 1-cycloheptyl-4-methoxybenzene 
• 56140-77-3 1-(4-methoxyphenyl)cyclohexane-1-carbaldehyde 

Relevant articles and documents

Enantioselective Nickel-Catalyzed Alkyne-Azide Cycloaddition by Dynamic Kinetic Resolution

The triazole heterocycle has been widely adopted as an isostere for the amide bond. Many native amides are α-chiral, being derived from amino acids. This makes α-N-chiral triazoles attractive building blocks. This report describes the first enantioselective triazole synthesis that proceeds via nickel-catalyzed alkyne-azide cycloaddition (NiAAC). This dynamic kinetic resolution is enabled by a spontaneous [3,3]-sigmatropic rearrangement of the allylic azide. The 1,4,5-trisubstituted triazole products, derived from internal alkynes, are complementary to those commonly obtained by the related CuAAC reaction. Initial mechanistic experiments indicate that the NiAAC reaction proceeds through a monometallic Ni complex, which is distinct from the CuAAC manifold.

Synthesis of multisubstituted cycloalkenes through carbomagnesiation of strained cycloalkynes

An efficient synthetic method of seven- and six-membered cycloalkenes through the generation of strained cycloalkynes and following carbomagnesiation is described. Further bond formations of the resulting cycloalkenylmagnesium intermediates with a wide variety of electrophiles enabled us to prepare diverse cycloalkene derivatives including benzoxepine analogs having a fully substituted alkene structure.

Lewis Acid Catalyzed Transfer Hydromethallylation for the Construction of Quaternary Carbon Centers

The design and gram-scale synthesis of a cyclohexa-1,4-diene-based surrogate of isobutene gas is reported. Using the highly electron-deficient Lewis acid B(C6F5)3, application of this surrogate in the hydromethallylation of electron-rich styrene derivatives provided sterically congested quaternary carbon centers. The reaction proceeds by C(sp3)?C(sp3) bond formation at a tertiary carbenium ion that is generated by alkene protonation. The possibility of two concurrent mechanisms is proposed on the basis of mechanistic experiments using a deuterated surrogate.