330-85-8

Basic information

• Product Name: 4-FLUORO DIPHENYL SULFIDE
• Synonyms: 4-FLUORO DIPHENYL SULFIDE;4-Fluorodiphenylsulphide;4-Fluoro diphenyl su;1-fluoro-4-(phenylsulfanyl)benzene
• CAS NO: 330-85-8
• Molecular Formula: C₁₂H₉FS
• Molecular Weight: 204.2632632
• Mol File: 330-85-8.mol
• Article Data: 73

Chemical Properties

• Boiling Point: 308.1 °C at 760 mmHg
• Flash Point: 140.1 °C
• Appearance: /
• Density: 1.2 g/cm³
• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.621
• CAS DataBase Reference: 4-FLUORO DIPHENYL SULFIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-FLUORO DIPHENYL SULFIDE(330-85-8)
• EPA Substance Registry System: 4-FLUORO DIPHENYL SULFIDE(330-85-8)

Safety Data

• Hazardous Substances Data: 330-85-8(Hazardous Substances Data)

Usage

General Description

4-Fluoro diphenyl sulfide is a chemical compound with the molecular formula C12H9FS. It is a crystalline solid that is insoluble in water and soluble in organic solvents. This chemical is commonly used as a building block in organic synthesis and pharmaceutical manufacturing. It has a wide range of applications, including as a reagent in the production of pharmaceuticals, agricultural chemicals, and materials science. Additionally, 4-fluoro diphenyl sulfide is also utilized in the manufacture of dyes, as well as in research and development activities in the chemical industry. It is important to handle this chemical with care, as it can be hazardous if proper safety measures are not taken.

InChI:InChI=1/C12H9FS/c13-10-6-8-12(9-7-10)14-11-4-2-1-3-5-11/h1-9H

Upstream product

• 591-50-4 iodobenzene 
• 371-42-6 4-Fluorothiophenol 
• 114650-59-8 C₁₂H₉FN₂S 
• 108-98-5 thiophenol 
• 460-00-4 1-Bromo-4-fluorobenzene 
• 1192-40-1 copper(I) thiophenolate 
• 405-31-2 bis(4-fluorophenyl)disulfide 
• 71-43-2 benzene 
• 352-13-6 4-flourophenylmagnesium bromide 
• 194720-38-2 2,3,5,6-tetramethyl-4-oxo-1-phenylthiocyclohexa-2,5-dienyl 2-chloroacetate 
• 352-34-1 4-fluoro-1-iodobenzene 
• 931-59-9 benzenesulfenyl chloride 
• 371-40-4 4-fluoroaniline 
• 369-57-3 benzenediazonium tetrafluoroborate 

Downstream Products

• 40154-93-6 (4-fluorophenyl)(phenyl) sulfoxide 
• 99433-23-5 1-(4-((4-fluorophenyl)thio)phenyl)ethan-1-one 
• 154093-57-9 (4-fluorophenyl)diphenylsulfonium trifluoromethanesulfonate 
• 177586-38-8 2-fluorodibenzothiophene 
• 40154-96-9 SC₆H₅(OC(CF₃)2C₆H₅)2C₆H₄F 
• 127855-21-4 (4-fluorophenyl)diphenylsulfonium hexafluoroantimonate 
• 126799-52-8 1-Methyl-4-(4-(phenylthio)phenoxy)piperidine 
• 312-31-2 4-(phenylsulfonyl)fluorobenzene 

Relevant articles and documents

REACTIONS OF SOME BROMOFLUOROBENZENES WITH COPPER(I) BENZENETHIOLATE

The reactions of copper(I) benzenethiolate with some bromofluorobenzenes have resulted in the replacement of the bromine by a phenylthio group.Combinations of this method and the reactions of sodium thiolates with fluorobenzenes have enabled various isomeric phenylthio substituted fluorobenzenes C6HxFy(SR)z to be prepared.The new products have been characterized by elemental analysis, mass, infrared, and fluorine NMR spectroscopy.

Rh(I)-Catalyzed Intramolecular Decarbonylation of Thioesters

Decarbonylative synthesis of thioethers from thioesters proceeds in the presence of a catalytic amount of [Rh(cod)Cl]2 (2 mol %). The protocol represents the first Rh-catalyzed decarbonylative thioetherification of thioesters to yield valuable thioethers. Notable features include the absence of phosphine ligands, inorganic bases, and other additives and excellent group tolerance to aryl chlorides and bromides that are problematic using other metals to promote decarbonylation. Gram scale synthesis, late-stage pharmaceutical derivatization, and orthogonal site-selective cross-couplings by C-S/C-Br cleavage are reported.

Chan-Lam-Type C-S Coupling Reaction by Sodium Aryl Sulfinates and Organoboron Compounds

A Chan-Lam-Type C-S coupling reaction using sodium aryl sulfinates has been developed to provide diaryl thioethers in up to 92% yields in the presence of a copper catalyst and potassium sulfite. Both electron-rich and electron-poor sodium aryl sulfinates and diverse organoboron compounds were tolerated for the synthesis of aryl and heteroaryl thioethers and dithioethers. The mechanistic study suggested that potassium sulfite was involved in the deoxygenation of sulfinate through a radical process.