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Usage

Uses

Used in Pharmaceutical Industry:
2-Chloro-3-phenylquinazolin-4(3H)-one is used as a key intermediate in the synthesis of various pharmaceuticals for its potential biological activities.
Used in Antitumor Applications:
In the field of medicinal chemistry, 2-CHLORO-3-PHENYLQUINAZOLIN-4(3H)-ONE is used as an antitumor agent, showing potential in the development of drugs targeting cancer cells.
Used in Anti-inflammatory Applications:
2-CHLORO-3-PHENYLQUINAZOLIN-4(3H)-ONE is also used as an anti-inflammatory agent, indicating its potential use in the treatment of inflammation-related conditions.
Used in Antifungal Applications:
2-Chloro-3-phenylquinazolin-4(3H)-one is utilized as an antifungal agent, suggesting its application in the development of antifungal medications to combat fungal infections.
Used in Organic Compounds Production:
As a chemical intermediate, 2-CHLORO-3-PHENYLQUINAZOLIN-4(3H)-ONE is used in the production of other organic compounds, contributing to the synthesis of a variety of chemical products.

InChI:InChI=1/C14H9ClN2O/c15-14-16-12-9-5-4-8-11(12)13(18)17(14)10-6-2-1-3-7-10/h1-9H

Upstream product

• 603-23-6 3-phenyl-2,4-(1H,3H)-quinazolinedione 
• 18741-24-7 3-phenyl-2-thioxo-2,3-dihydro-1H-quinazolin-4-one 
• 103-72-0 phenyl isothiocyanate 
• 118-92-3 anthranilic acid 

Downstream Products

• 10204-16-7 2-(butylamino)-3-phenylquinazolin-4(3H)-one 
• 76462-02-7 3a-Ethoxy-2,4-diphenyl-3a,4-dihydro-oxazolo[3,2-a]quinazoline-1,5-dione 
• 59342-38-0 4-phenyl-4,5-dihydrotetrazolo<1,2-a>-5-quinazolone 
• 731-52-2 2-hydrazino-3-phenyl-3H-quinazolin-4-one 
• 76462-03-8 1-Benzylsulfanyl-4-phenyl-4H-[1,2,4]triazolo[4,3-a]quinazolin-5-one 
• 67811-46-5 4-phenyl-5-oxo-4,5-dihydro-s-triazolo-<4,3-a>-quinazoline 
• 67442-90-4 4-phenyl-5-oxo-1-thioxo-1,2,4,5-tetrahydro-s-triazolo<4,3-a>-quinazoline 
• 55536-48-6 1-benzyl-2,3-dihydroimidazo[2,1-b]quinazolin-5(1H)-one 
• 32725-30-7 2,3-dihydroimidazo<2,1-b>quinazolin-5(1H)-one 

Relevant academic research and scientific papers

2-HETEROARYL AMINOQUINAZOLINONE DERIVATIVE

Provided is a 2-heteroaryl aminoquinazolinone derivative, which is a compound represented by formula (1): or a pharmaceutically acceptable salt thereof wherein X1 represents CR1 or N, X2 represents CR2 or N, X3 represents CR3 or N, X4 represents CR4 or N, Y represents optionally substituted C1-6 alkyl, an optionally substituted C3-10 alicyclic group, an optionally substituted 4- to 10-membered nitrogen-containing non-aryl heterocycle, optionally substituted C6-10 aryl, or optionally substituted 5- to 10-membered heteroaryl, Z represents optionally substituted 6- to 10-membered heteroaryl, and R1, R2, R3, and R4 each independently represent a hydrogen atom, halogen, cyano, optionally substituted C1-6 alkyl, optionally substituted C1-6 alkoxy, or the like.

Divergent 2-Chloroquinazolin-4(3H)-one Rearrangement: Twisted-Cyclic Guanidine Formation or Ring-Fused N-Acylguanidines via a Domino Process

A highly efficient 2-chloroquinazolin-4(3H)-one rearrangement was developed that predictably generates either twisted-cyclic or ring-fused guanidines in a single operation, depending on the presence of a primary versus secondary amine in the accompanying diamine reagent. Exclusive formation of twisted-cyclic guanidines results from pairing 2-chloroquinazolinones with secondary diamines. Use of primary amine-containing diamines permits a domino quinazolinone rearrangement/intramolecular cyclization, gated through (E)-twisted-cyclic guanidines, to afford ring-fused N-acylguanidines. This scalable, structurally tolerant transformation generated 55 guanidines and delivered twisted-cyclic guanidines with robust plasma stability and an abbreviated total synthesis of an antitumor ring-fused guanidine (4 steps, 55 % yield).

2-[3-(4-morpholinyl)propylamine]-3-aryl-4-quinolinone compounds and application thereof

The invention belongs to the technical field of medicines and relates to 2-[3-(4-morpholinyl)propylamine]-3-aryl-4-quinolinone compounds and an application thereof. 2-[3-(4-morpholinyl)propylamine]-3-aryl-4-quinolinone derivatives comprise stereisomers and pharmaceutically applicable salts of the compounds and have the general structural formula shown in the description, wherein R is described inthe claims and description. The 2-[3-(4-morpholinyl)propylamine]-3-aryl-4-quinolinone derivatives and pharmaceutically applicable acid-added salts of the compounds can be combined with existing medicines or used separately to serve as influenza virus inhibitors to treat influenza and have better curative effects on various type-A influenza in particular.

Synthesis, properties, and mass-spectrometric fragmentation of 2-thio derivatives of 3-arylquinazolin-4-ones

We have studied the reactions of alkylation, oxidation, and hydrolysis of 3-aryl-2-thioxoquinazolin-4-ones. Alkylation in an alkaline medium occurs exclusively at the sulfur atom. Oxidation by hydrogen peroxide leads to formation of 3-arylquinazoline-2,4-diones. The latter are also obtained in base or acid hydrolysis of the synthesized S-alkyl derivatives. When 3-aryl-2-thioxoquinazolin-4-ones are reacted with iodine, we obtain the disulfides, while the reaction with chlorine in hydrochloric acid leads to 2-chloroquinazolin-4-ones. Studying the mass spectrometric behavior of the compounds obtained made it possible to observe in the gas phase ring-chain isomerization of the heterocyclic ring, and also S-N migration of the propargyl radical in molecular ions of the S-propargyl derivatives.

Fungicidal azole compounds

Compounds of the formula: STR1 where: A is oxygen or sulphur; R1 is phenyl or substituted phenyl in which the substituent is at least one member selected from the group consisting of halogen, C1-6 -alkyl, C1-6 -haloalkyl, C1-6 -alkoxy, C1-6 -haloalkoxy and nitro; R2 is 1-imidazoly of 1,2,4-triazol-1-yl; and R3, R4, R5 and R6, which may be the same or different, are each hydrogen, halo, C1-6 -alkyl or C1-6 -alkoxy have valuable fungicidal properties.

Synthesis of Some Fused-ring Derivatives from 4(3H)-Quinazolone

A few more well-defined mesoionic thiazoloquinazolones have been synthesized and their properties recorded.Attempts to build-up analogous fused-ring mesoionic systems via 2-chloro-3-phenyl-4-quinazolone have not been successful.Several new triazolo