33209-75-5

Usage

Uses

Used in Pharmaceutical Industry:
4-(2-methoxyphenyl)butyric acid is used as a chiral building block for the synthesis of various drugs, contributing to the development of new medications with improved efficacy and selectivity.
Used in Treatment of Pulmonary Fibrosis:
4-(2-methoxyphenyl)butyric acid is used as a potential therapeutic agent for pulmonary fibrosis, leveraging its anti-inflammatory and antifibrotic properties to alleviate the symptoms and progression of the disease.
Used in Treatment of Liver Fibrosis:
4-(2-methoxyphenyl)butyric acid is used as a potential therapeutic agent for liver fibrosis, utilizing its anti-inflammatory and antifibrotic properties to mitigate the effects of liver scarring and improve liver function.

Upstream product

• 996-82-7 sodium diethylmalonate 
• 36449-75-9 1-(2-bromoethyl)-2-methoxybenzene 
• 72734-85-1 1-(3-chloropropyl)-2-methoxybenzene 
• 77853-46-4 4-(2-Methoxyphenyl)-butanenitrile 
• 103987-16-2 β-methoxy-γ-oxo-γ-phenylbutanoic acid 
• 93108-08-8 methyl 4-(2'-methoxyphenyl)butanoate 
• 99046-13-6 4-oxo-4-(2-methoxyphenyl)butyric acid methyl ester 
• 108840-41-1 1-(2-methoxy-phenyl)-2-(toluene-4-sulfonyloxy)-ethane 
• 105-53-3 diethyl malonate 
• 33209-76-6 Ethyl 4-(2-Methoxyphenyl)-butanoate 
• 90266-01-6 1-diazo-4-(2'-methoxyphenyl)butan-2-one 
• 93-25-4 2-methoxyphenylacetic acid 
• 6342-77-4 2-methoxy-benzenepropanoic acid 
• 1011-54-7 2-methoxycinnamic acid 

Downstream Products

• 93108-08-8 methyl 4-(2'-methoxyphenyl)butanoate 
• 33209-76-6 Ethyl 4-(2-Methoxyphenyl)-butanoate 
• 33892-75-0 5-Methoxy-1-tetralone 
• 161053-79-8 4-(2-methoxy-phenyl)-butyryl chloride 
• 22565-26-0 4-(2-Methoxy-cyclohexyl)-butanol-⁽¹⁾ 
• 19142-95-1 Thiosulfuric acid S-{2-[4-(2-methoxy-cyclohexyl)-butylamino]-ethyl} ester 
• 21782-51-4 4-(o-Methoxy-cyclohexyl)-butylbromid 
• 33209-77-7 2-Methyl-5-o-anisyl-2-pentanol 
• 33214-70-9 1,1-dimethyl-5-methoxytetralin 

Relevant academic research and scientific papers

A heavy-metal-free desulfonylative Giese-type reaction of benzothiazole sulfones under visible-light conditions

A visible-light-induced desulfonylative Giese-type reaction has been developed. Essential to the success is the employment of Hantzsch ester to activate benzothiazole sulfones without any heavy-metal additives. Not only benzylic benzothiazole sulfones but also alkyl ones were viable substrates and reacted with electron-deficient alkenes and a propiol amide.

Carbonylative Transformation of Allylarenes with CO Surrogates: Tunable Synthesis of 4-Arylbutanoic Acids, 2-Arylbutanoic Acids, and 4-Arylbutanals

In this Communication, procedures for the selective synthesis of 4-arylbutanoic acids, 2-arylbutanoic acids, and 4-arylbutanals from the same allylbenzenes have been developed. With formic acid or TFBen as the CO surrogate, reactions proceed selectively and effectively under carbon monoxide gas-free conditions.

Design, synthesis, and evaluation of novel inhibitors for wild-type human serine racemase

Most of the endogenous free D-serine (about 90%) in the brain is produced by serine racemase (SR). D-Serine in the brain is involved in neurodegenerative disorders and epileptic states as an endogenous co-agonist of the NMDA-type glutamate receptor. Thus, SR inhibitors are expected to be novel therapeutic candidates for the treatment of these disorders. In this study, we solved the crystal structure of wild-type SR, and tried to identify a new inhibitor of SR by in silico screening using the structural information. As a result, we identified two hit compounds by their in vitro evaluations using wild-type SR. Based on the structure of the more potent hit compound 1, we synthesized 15 derivatives and evaluated their inhibitory activities against wild-type SR. Among them, the compound 9C showed relatively high inhibitory potency for wild-type SR. Compound 9C was a more potent inhibitor than compound 24, which was synthesized by our group based upon the structural information of the mutant-type SR.

Discovery of synthetic methoxy-substituted 4-phenylbutyric acid derivatives as chemical chaperones

In this study, we evaluated the chemical chaperone activity of synthetic 4-phenylbutyric acid (4-PBA) derivatives. These derivatives have a methoxy group at the benzene ring and/or longer or shorter fatty acid portions. Several 4-PBA derivatives demonstrated higher antiaggregation activity than 4-PBA. Moreover, 4-(4-methoxyphenyl)butanoic acid (7b) showed protective effects against endoplasmic reticulum stress-induced neuronal cell death.

STUDIES ON OXYGEN HETEROCYCLES PART-1 : ACID CATALYSED AND PHOTOCHEMICAL REACTIONS OF SOME ARYLDIAZOKETONES

Trifluoroacetic acid catalysed reaction of 2-methoxyphenyldiazomethylketone (4a), 2-acetoxyphenyldiazomethylketone (4b) and 3-(2-anisyl)-α-diazo-2-propanone (11) leads to the formation of coumaranone (6) and 3-chromanone (12), while 4-(2-anisyl)-α-diazo-2-butanone (16) affords benzo-1-oxepan-3-one (17) and 5-methoxy-2-tetralone (18) in moderate yield.The photochemical decomposition of the said diazoketones (4a, 11 and 16) gave products depending on the length of the side chain present in the substrates.