33224-19-0

Usage

Uses

Used in Pharmaceutical Industry:
3-Methoxy-5-nitrobenzonitrile serves as an intermediate in the synthesis of various pharmaceuticals. It is utilized for its ability to contribute to the formation of complex molecular structures that can exhibit therapeutic properties.
Used in Agrochemical Industry:
In the agrochemical sector, 3-Methoxy-5-nitrobenzonitrile is employed as an intermediate in the production of agrochemicals, which are essential for enhancing crop protection and yield.
Used in Dye Industry:
3-Methoxy-5-nitrobenzonitrile is also used in the dye industry, where it acts as an intermediate for synthesizing dyes that impart color to various materials.
Used in Organic Synthesis:
3-methoxy-5-nitrobenzonitrile is a valuable building block in organic synthesis, enabling the production of a wide range of other chemical compounds for diverse applications.

Upstream product

• 16618-67-0 3-bromo-5-nitroanisole 
• 544-92-3 copper(I) cyanide 
• 5327-44-6 3,5-dinitroanisole 
• 586-10-7 3-methoxy-5-nitroaniline 
• 4110-35-4 3,5-dinitrobenzonitrile 
• 78238-12-7 3-methoxy-5-nitrobenzoic acid 
• 99-34-3 3,5-dinitrobenzoic acid 
• 292635-40-6 3-methoxy-5-nitrobenzamide 
• 85276-68-2 3-methoxy-5-nitrobenzoyl chloride 
• 1527-89-5 3-methoxybenzonitrile 
• 1035266-33-1 3-methoxy-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)benzonitrile 

Downstream Products

• 269411-71-4 3-amino-5-methoxy-benzonitrile 
• 354512-22-4 3-methoxyl-5-nitrobenzaldehyde 

Relevant academic research and scientific papers

meta-Nitration of Arenes Bearing ortho/para Directing Group(s) Using C?H Borylation

Herein, we report the meta-nitration of arenes bearing ortho/para directing group(s) using the iridium-catalyzed C?H borylation reaction followed by a newly developed copper(II)-catalyzed transformation of the crude aryl pinacol boronate esters into the corresponding nitroarenes in a one-pot fashion. This protocol allows the synthesis of meta-nitrated arenes that are tedious to prepare or require multistep synthesis using the existing methods. The reaction tolerates a wide array of ortho/para-directing groups, such as ?F, ?Cl, ?Br, ?CH3, ?Et, ?iPr ?OCH3, and ?OCF3. It also provides regioselective access to the nitro derivatives of π-electron-deficient heterocycles, such as pyridine and quinoline derivatives. The application of this method is demonstrated in the late-stage modification of complex molecules and also in the gram-scale preparation of an intermediate en route to the FDA-approved drug Nilotinib. Finally, we have shown that the nitro product obtained by this strategy can also be directly converted to the aniline or hindered amine through Baran's amination protocol.

Preparation technology of 3-cyano-5-anisole-1-sulfonyl chloride

The invention discloses a preparation technology of 3-cyano-5-anisole-1-sulfonyl chloride. The technology comprises the following steps: performing substitution reaction on a raw material which is 3,5-dinitrobenzene to obtain 3-anisyl-5-nitrobenzoic acid;

Synthesis of Unlabelled and Carboxyl-Labelled 3-Amino-5-hydroxybenzoic Acid

Efficient syntheses are reported of the natural amino acid 3-amino-5-hydroxybenzoic acid in unlabelled and carboxyl-labelled forms from 3,5-dinitrobenzoic acid and 3,5-dinitroanisole, respectively.