5327-44-6Relevant academic research and scientific papers
Clean production process for producing nitrobenzene alkoxy ether by using nitrohalogenated benzene
-
Paragraph 0049-0054, (2020/06/09)
The invention provides a clean production process for producing nitrobenzene alkoxy ether by using nitrohalogenated benzene. The specific production steps comprise: proportionally adding one or more than one non-polar solvents into a reactor, adding molten nitrohalogenated benzene into the reactor, uniformly stirring, and adding alkali metal alkoxide into the reactor at a constant speed; after thereaction is finished, adding water to washing the inorganic matters generated in the reaction process while recovering the solvent. According to the invention, the production process is simple, the catalyst separation efficiency in the reaction process is high, other substances irrelevant to the reaction are not added in the reaction process, the purity is high, the yield is high, byproducts arelow, the wastewater amount is low, and the reaction period is short; and the reaction device is operated in a totally-enclosed manner, so that the operation environment is improved, the harm to humanhealth is reduced, and the cost is saved.
Urea-linked, iodinated bis phenyl compounds for X-ray contrast media
-
, (2008/06/13)
The invention provides iodinated bis phenyl compounds, useful as X-ray contrast agents, of formula I STR1 (wherein each C6 R5 moeity may be the same or different; each R denotes a hydrogen or iodine atom or a group M, two or three non-adjacent R groups on each C6 R5 moiety denoting iodine atoms and one, two or three R groups on each C6 R5 moiety denoting M groups; X denotes a group providing a 1, 2 or 3 atom chain linking the two C6 R5 groups, preferably where X is or contains in the bridging chain a carbonyloxy group each C6 R5 group being a triodophenyl group or a group in which each R is other than hydrogen; and each M is independently a non-ionic hydrophilic moiety, M preferably being a non-ionic hydrophilic moiety comprising a monohydroxy- or polyhydroxy-alkyl group) and isomers, especially stereoisomers and rotamers, thereof.
Substituent Effects on the Decarboxylation of Dinitrobenzoate Ions, Representative Aromatic SE1 Reactions
Segura, Pascual,Bunnett, Joseph F.,Villanova, Laura
, p. 1041 - 1045 (2007/10/02)
Kinetics of decarboxylation, in water solution, of several 4-substituted 2,6-dinitrobenzoic and 2-substituted 4,6-dinitrobenzoic acids were determined, at several temperatures.The reactions are first order at the low concentrations employed, at which the acids are fully dissociated.Decarboxylation is accelerated by electron-attracting substituents; the Hammett ρ for the effects of 4-substituents is about +2.6.All the decarboxylations involve large positive enthalpies and entropies of activation.The solvent kinetic isotope effect (D2O/H2O) is not significantly different from unity.The data support a mechanism where in the substituted benzoate ion loses CO2 in the rate-determining step, forming a substituted aryl anion, which is then rapidly hydronated by the solvent.In the case of 2-methoxy-4,6-dinitrobenzoate ion, reaction occured with strikingly different activation parameters.
