3329-35-9

Usage

Uses

Used in Pharmaceutical Industry:
(1,3-dimethylbutyl)methylamine(SALTDATA: HCl) is used as an intermediate for the synthesis of various drugs. Its unique chemical structure allows it to be incorporated into the development of new pharmaceutical compounds, contributing to the advancement of medicine.
Used in Agrochemical Industry:
In the agrochemical sector, (1,3-dimethylbutyl)methylamine(SALTDATA: HCl) serves as a key component in the production of various agrochemicals. Its properties make it suitable for use in the development of pesticides, herbicides, and other agricultural chemicals, enhancing crop protection and yield.
Used in Research and Development:
(1,3-dimethylbutyl)methylamine(SALTDATA: HCl) is utilized in research and development laboratories for the creation of new medications and chemical products. Its versatility and reactivity make it a valuable tool for scientists working on innovative chemical syntheses and applications.
It is important to handle (1,3-dimethylbutyl)methylamine(SALTDATA: HCl) with care due to its potential hazards, and it should only be used by trained professionals in a controlled laboratory setting.

InChI:InChI=1/C7H17N/c1-6(2)5-7(3)8-4/h6-8H,5H2,1-4H3

Upstream product

• 108-10-1 4-methyl-2-pentanone 
• 74-89-5 methylamine 
• 67-56-1 methanol 
• 15761-50-9 2-amino-4-methylpentane 

Downstream Products

• 856813-30-4 N-(1,3-dimethyl-butyl)-N-methyl-β-alanine nitrile 

Relevant academic research and scientific papers

Selective Monomethylation of Amines with Methanol as the C1 Source

The N-monomethyl functionality is a common motif in a variety of synthetic and natural compounds. However, facile access to such compounds remains a fundamental challenge in organic synthesis owing to selectivity issues caused by overmethylation. To address this issue, we have developed a method for the selective, catalytic monomethylation of various structurally and functionally diverse amines, including typically problematic primary aliphatic amines, using methanol as the methylating agent, which is a sustainable chemical feedstock. Kinetic control of the aliphatic amine monomethylation was achieved by using a readily available ruthenium catalyst at an adequate temperature under hydrogen pressure. Various substrates including bio-related molecules and pharmaceuticals were selectively monomethylated, demonstrating the general utility of the developed method.

Photometric Characterization of the Reductive Amination Scope of the Imine Reductases from Streptomyces tsukubaensis and Streptomyces ipomoeae

Imine reductases (IREDs) have emerged as promising enzymes for the asymmetric synthesis of secondary and tertiary amines starting from carbonyl substrates. Screening the substrate specificity of the reductive amination reaction is usually performed by time-consuming GC analytics. We found two highly active IREDs in our enzyme collection, IR-20 from Streptomyces tsukubaensis and IR-Sip from Streptomyces ipomoeae, that allowed a comprehensive substrate screening with a photometric NADPH assay. We screened 39 carbonyl substrates combined with 17 amines as nucleophiles. Activity data from 663 combinations provided a clear picture about substrate specificity and capabilities in the reductive amination of these enzymes. Besides aliphatic aldehydes, the IREDs accepted various cyclic (C4–C8) and acyclic ketones, preferentially with methylamine. IR-Sip also accepted a range of primary and secondary amines as nucleophiles. In biocatalytic reactions, IR-Sip converted (R)-3-methylcyclohexanone with dimethylamine or pyrrolidine with high diastereoselectivity (>94–96 % de). The nucleophile acceptor spectrum depended on the carbonyl substrate employed. The conversion of well-accepted substrates could also be detected if crude lysates were employed as the enzyme source.