333363-51-2Relevant academic research and scientific papers
Synthetic Studies of Tamandarin B Side Chain Analogues
Lassen, Kenneth M.,Lee, Jisun,Joullie, Madeleine M.
experimental part, p. 3027 - 3036 (2010/07/13)
The syntheses of three tamandarin B analogues are described. The goal of these studies was to prepare material to determine their relative therapeutic index and to gain an oversight as to their potential for clinical applications.
Structure-activity relationships of side-chain modified didemnins
Ding, Xiaobin,Vera, Matthew D.,Liang, Bo,Zhao, Yuming,Leonard, Michael S.,Joullie, Madeleine M.
, p. 231 - 234 (2007/10/03)
The synthesis and antitumor activity of a novel didemnin B analogue containing a ψ[CH2NH] amide bond surrogate between N-Me-D-Leu7 and Pro8 are reported. The analogue shows activity (GI50 = 4 nM) comparable to that of didemnin B (GI50 = 13 nM) in the NCI-60 tumor cell screen. This result, along with new data from previously reported synthetic didemnin analogues, is discussed within the context of the side-chain SAR for didemnins.
