129919-89-7

Basic information

• Product Name: N-(tert-butoxycarbonyl)-N-methyl-D-leucine benzyl ester
• Synonyms: N-(tert-butoxycarbonyl)-N-methyl-D-leucine benzyl ester
• CAS NO: 129919-89-7
• Molecular Weight: 335.444
• Mol File: 129919-89-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: N-(tert-butoxycarbonyl)-N-methyl-D-leucine benzyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: N-(tert-butoxycarbonyl)-N-methyl-D-leucine benzyl ester(129919-89-7)
• EPA Substance Registry System: N-(tert-butoxycarbonyl)-N-methyl-D-leucine benzyl ester(129919-89-7)

Safety Data

• Hazardous Substances Data: 129919-89-7(Hazardous Substances Data)

Upstream product

• 158804-50-3 Boc-D-leucine benzyl ester 
• 74-88-4 methyl iodide 
• 100-39-0 benzyl bromide 
• 89536-84-5 N-tert-butoxycarbonyl-N-methyl-D-leucine 

Downstream Products

• 333363-53-4 (R)-4-Methyl-2-{methyl-[(S)-1-(2-oxo-propionyl)-pyrrolidin-2-ylmethyl]-amino}-pentanoic acid benzyl ester 
• 333363-51-2 L-lactyl-Pro-ψ(NHCH2)-N-methyl-D-leucine benzyl ester 
• 333363-48-7 N-Boc-Pro-ψ(NHCH2)-N-methyl-leucine benzyl ester 
• 89536-86-7 H-N-Me-D-Leu-OBzl 

Relevant articles and documents

Total synthesis and structural investigations of didemnins A, B, and C

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Structure-activity relationships of side-chain modified didemnins

The synthesis and antitumor activity of a novel didemnin B analogue containing a ψ[CH2NH] amide bond surrogate between N-Me-D-Leu7 and Pro8 are reported. The analogue shows activity (GI50 = 4 nM) comparable to that of didemnin B (GI50 = 13 nM) in the NCI-60 tumor cell screen. This result, along with new data from previously reported synthetic didemnin analogues, is discussed within the context of the side-chain SAR for didemnins.