333363-53-4Relevant academic research and scientific papers
Structure-activity relationships of side-chain modified didemnins
Ding, Xiaobin,Vera, Matthew D.,Liang, Bo,Zhao, Yuming,Leonard, Michael S.,Joullie, Madeleine M.
, p. 231 - 234 (2001)
The synthesis and antitumor activity of a novel didemnin B analogue containing a ψ[CH2NH] amide bond surrogate between N-Me-D-Leu7 and Pro8 are reported. The analogue shows activity (GI50 = 4 nM) comparable to that of didemnin B (GI50 = 13 nM) in the NCI-60 tumor cell screen. This result, along with new data from previously reported synthetic didemnin analogues, is discussed within the context of the side-chain SAR for didemnins.
