33358-41-7

Upstream product

• 611-06-3 2,4-dichloronitrobenzene 
• 930-69-8 sodium thiophenolate 
• 64-17-5 ethanol 
• 610-40-2 3,4-dinitro-chlorobenzene 
• 14371-79-0 2-nitro-5-chlorothiophenol 
• 108-90-7 chlorobenzene 
• 700-37-8 4-chloro-2-fluoro-nitrobenzene 
• 108-98-5 thiophenol 
• 882-33-7 diphenyldisulfane 
• 18640-60-3 5-chloro-2-nitroacetophenone 

Downstream Products

• 1635-61-6 5-chloro-2-nitroaniline 
• 1696-40-8 5-Methoxy-2-nitro-diphenylsulfid 
• 672295-04-4 (5-chloro-2-nitro-phenyl)-phenyl sulfone 
• 53692-01-6 4-chloro-2-phenylsulfanylphenylamine 

Relevant academic research and scientific papers

Synthesis of thioethers, arenes and arylated benzoxazoles by transformation of the C(aryl)-C bond of aryl alcohols

Transformation of aryl alcohols into high-value functionalized aromatic compounds by selective cleavage and functionalization of the C(aryl)-C(OH) bond is of crucial importance, but very challenging by far. Herein, for the first time, we report a novel and versatile strategy for activation and functionalization of C(aryl)-C(OH) bonds by the cooperation of oxygenation and decarboxylative functionalization. A diverse range of aryl alcohol substrates were employed as arylation reagents via the cleavage of C(aryl)-C(OH) bonds and effectively converted into corresponding thioether, arene, and arylated benzoxazole products in excellent yields, in a Cu based catalytic system using O2 as the oxidant. This study offers a new way for aryl alcohol conversion and potentially offers a new opportunity to produce high-value functionalized aromatics from renewable feedstocks such as lignin which features abundant C(aryl)-C(OH) bonds in its linkages.

Ortho-selectivity in SNAr substitutions of 2,4-dihaloaromatic compounds. Reactions with anionic nucleophiles

The nucleophilic addition of organic anions to aromatic compounds with halogens positioned both ortho and para to activating groups was studied in a variety of solvents. Substrates showed strong preferences for ortho substitution in most cases. Evidence is presented for activating group-dependent coordination, which contributes to very high ortho-selectivity in nonpolar solvents. This also drives the overall reaction rate in these solvents, and is of close to the same magnitude of rate increase derived from polar solvents. para-Products are maximized by using crown ethers in protic solvents. Solvent effects overall are very different from corresponding reactions with amine nucleophiles due primarily to the different charges present in the transition states, and to solvation of the nucleophile.

CCR9 INHIBITORS AND METHODS OF USE THEREOF

The invention relates to compounds represented by Structural Formula I, which can bind to CCR9 receptors and block the binding of a ligand (e.g., TECK) to the receptors. The invention also relates to a method of inhibiting a function of CCR9, and to the use compounds represented by Structural Formula I in research, therapeutic, prophylactic and diagnostic methods.

Electron ionization-induced loss of SO2 from 2-nitrodiaryl sulfides

Electron ionization-induced loss of SO2 from 2-nitrodiphenyl sulfide leads to the same ionic structure, or mixture of structures, as loss of N2 from the molecular ion of N1-phenylbenzotriazole. Ab initio calculations are i