33358-41-7Relevant articles and documents
New class of antihypertensive agents.
RUBIN,ROTH,WINBURY,TOPLISS,SHERLOCK,SPERBER,BLACK
, p. 2067 - 2067 (1961)
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Ortho-selectivity in SNAr substitutions of 2,4-dihaloaromatic compounds. Reactions with anionic nucleophiles
Wendt, Michael D.,Kunzer, Aaron R.
scheme or table, p. 3041 - 3044 (2010/07/18)
The nucleophilic addition of organic anions to aromatic compounds with halogens positioned both ortho and para to activating groups was studied in a variety of solvents. Substrates showed strong preferences for ortho substitution in most cases. Evidence is presented for activating group-dependent coordination, which contributes to very high ortho-selectivity in nonpolar solvents. This also drives the overall reaction rate in these solvents, and is of close to the same magnitude of rate increase derived from polar solvents. para-Products are maximized by using crown ethers in protic solvents. Solvent effects overall are very different from corresponding reactions with amine nucleophiles due primarily to the different charges present in the transition states, and to solvation of the nucleophile.
Electron ionization-induced loss of SO2 from 2-nitrodiaryl sulfides
Lambert,Bertin,Lacoste,Volland,Krick,Furet,Botrel,Guenot
, p. 242 - 249 (2007/10/03)
Electron ionization-induced loss of SO2 from 2-nitrodiphenyl sulfide leads to the same ionic structure, or mixture of structures, as loss of N2 from the molecular ion of N1-phenylbenzotriazole. Ab initio calculations are i
