333985-88-9

Basic information

• Product Name: 1-Piperidinecarboxylic acid, 4-(2-pyridinylthio)-, 1,1-dimethylethyl ester
• Synonyms: 4-(PYRIDIN-2-YLSULFANYL)-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;1-Piperidinecarboxylic acid, 4-(2-pyridinylthio)-, 1,1-dimethylethyl ester
• CAS NO: 333985-88-9
• Molecular Formula: C₁₅H₂₂N₂O₂S
• Molecular Weight: 294.41
• Mol File: 333985-88-9.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 418.5±35.0 °C(Predicted)
• Appearance: /
• Density: 1.16±0.1 g/cm3(Predicted)
• PKA: 2.93±0.19(Predicted)
• CAS DataBase Reference: 1-Piperidinecarboxylic acid, 4-(2-pyridinylthio)-, 1,1-dimethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Piperidinecarboxylic acid, 4-(2-pyridinylthio)-, 1,1-dimethylethyl ester(333985-88-9)
• EPA Substance Registry System: 1-Piperidinecarboxylic acid, 4-(2-pyridinylthio)-, 1,1-dimethylethyl ester(333985-88-9)

Safety Data

• Hazardous Substances Data: 333985-88-9(Hazardous Substances Data)

Usage

Molecular Weight

270.36 g/mol

Structure

Consists of a piperidine ring with a carboxylic acid group, a 2-pyridinylthio group, and a 1,1-dimethylethyl ester group.

Usage

Commonly used as an intermediate in the synthesis of various drugs, including antihistamines and antihypertensive medications. Also used as an ingredient in the manufacturing of certain pesticides and herbicides.

Properties

Known for its ability to modify and enhance the properties of other chemicals, making it a valuable tool in drug development and research. Versatile and important in various industries.

Upstream product

• 84358-13-4 N-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid 
• 2127-03-9 2,2'-dipyridyldisulphide 
• 1872262-73-1 1-(tert-butyl) 4-(1,3-dioxoisoindolin-2-yl) piperidine-1,4-dicarboxylate 
• 5029-67-4 2-iodopyridine 
• 134464-79-2 tert-butyl 4-mercapto-1-piperidinecarboxylate 
• 2637-34-5 2-Sulfanylpyridine 
• 180695-79-8 tert-butyl 4-bromo-1-piperidinecarboxylate 
• 109384-19-2 t-butyl 4-hydroxy piperidine-1-carboxylate 

Downstream Products

• 333989-82-5 1-Acetyl-N-(3-chlorophenyl)-N-[3-[4-(2-pyridinylthio)-1-piperidinyl]propyl]-4-piperidinecarboxamide Trifluoroacetate 

Relevant articles and documents

Visible Light-Driven Decarboxylative Alkylation of Aldehydes via Electron Donor–Acceptor Complexes of Active Esters

There are some synthesis methods from widely available aldehydes to the corresponding ketones, however, they involved in multistep reactions with Grignard’s reagents or transition metal catalysts. In this paper, we have developed photocatalyst-free and visible light-driven decarboxylative alkylation of pyridinaldehydes. The photochemical reactions are initiated via photoinduced single electron transfer from triethylamine to N-hydroxyphthalimide esters in electron donor–acceptor complexes. This photochemical method can achieve to translate 15 pyridinaldehydes and 11 2-quinolinaldehydes to the corresponding ketones. Furthermore, this strategy can also achieve two other transformations, disulfanes to aryl sulfides and a styrene sulfone to the alkyl-substituted alkene.

Peptide compounds

The present invention relates to a compound of the formula (I)wherein R1 is benzofuranyl substituted by halogen, or styryl substituted by halogen; R2 is substituted hydroxy, substituted mercapto or substituted sulfonyl; and X is or pharmaceutically acceptable salts thereof. The compound (1) of the present invention and pharmaceutically acceptable salts thereof possess a strong inhibitory activity on the production of nitric oxide (NO), and are useful for prevention and/or treatment of NO-mediated diseases in human being and animals.