334477-48-4

Basic information

• Product Name: methyl 2-(3,5-bis(trifluoromethyl)phenyl)-2-methylpropanoate
• Synonyms: methyl 2-(3,5-bis(trifluoromethyl)phenyl)-2-methylpropanoate
• CAS NO: 334477-48-4
• Molecular Weight: 314.227
• Mol File: 334477-48-4.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: methyl 2-(3,5-bis(trifluoromethyl)phenyl)-2-methylpropanoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 2-(3,5-bis(trifluoromethyl)phenyl)-2-methylpropanoate(334477-48-4)
• EPA Substance Registry System: methyl 2-(3,5-bis(trifluoromethyl)phenyl)-2-methylpropanoate(334477-48-4)

Safety Data

• Hazardous Substances Data: 334477-48-4(Hazardous Substances Data)

Upstream product

• 149-73-5 trimethyl orthoformate 
• 95299-16-4 methyl [3,5-bis(trifluoromethyl)-phenyl]-acetate 
• 74-88-4 methyl iodide 

Downstream Products

• 374791-63-6 α,α-dimethyl-N-[4-oxo-1-phenylcyclohexyl]-3,5-bis(trifluoromethyl)benzeneacetamide 
• 488098-44-8 α,α-dimethyl-3,5-bis(trifluoromethyl)benzenemethanamine 
• 289686-70-0 α,α-Dimethyl-3,5-bis(trifluoromethyl)benzeneacetic Acid 

Relevant articles and documents

Preparation method of synthetic 2-(3,5-bis(trifluoromethyl)phenyl)-2-methyl propioric acid

The invention discloses a preparation method of synthetic 2-(3,5-bis(trifluoromethyl)phenyl)-2-methyl propioric acid. S1: 3,5-bis(trifluoromethyl)bromobenzene is dissolved in an organic solvent, the solution is added dropwisely into isopropylmagnesium chloride, and a Grignard reagent is obtained; mafosfamide is dissolved in an organic solvent, the solution is added dropwisely into the Grignard reagent, in order to obtain 2-(3,5-bis(trifluoromethyl)phenyl)-2-methyl propyl-1-ketone; S2: 2-(3,5-bis(trifluoromethyl)phenyl)-2-methyl propyl-1-ketone obtained in the step S1 is dissolved in an organicsolvent, and 2-(3,5-bis(trifluoromethyl)phenyl)-2-bromo-methyl propyl-1-ketone is obtained; S3: 2-(3,5-bis(trifluoromethyl)phenyl)-2-bromo-2-methyl propyl-1-ketone obtained in the step S2 is dissolved in an organic solvent, zinc bromide is added, in order to obtain 2-(3,5-bis(trifluoromethyl)phenyl)-2-methyl methacrylate; S4: 2-(3,5-bis(trifluoromethyl)phenyl)-2-methyl methacrylate obtained in the step S3 is dissolved in an organic solvent, the solution is added into an aqueous solution of alkali, and 2-(3,5-bis(trifluoromethyl)phenyl)-2-methyl propioric acid is obtained.

PIPERIDINE COMPOUND AND PROCESS FOR PREPARING THE SAME

The present invention is to provide a piperidine compound represented by the formula [I]: wherein Ring A is an optionally substituted benzene ring, Ring B is an optionally substituted benzene ring, R1 is hydrogen atom or a substituent for amino group, R2 is hydrogen atom, an optionally substituted hydroxyl group, an optionally substituted amino group, an optionally substituted alkyl group, a substituted carbonyl group or a halogen atom, Z is oxygen atom or -N(R3)-, R3 is hydrogen atom or an optionally substituted alkyl group, R4a and R4b may be the same or different, and each is hydrogen atom or an optionally substituted alkyl group, or a pharmaceutically acceptable salt thereof, which has an excellent tachykinin receptor antagonistic action.

Cyclohexane derivatives and their use as therapeutic agents

The present invention relates compounds of formula (I), wherein ring A is a phenyl or pyridyl ring; X represents a linker selected from the group consisting of formulae: (a), (b), (c), (d), and (e); and R1, R2, R3, R4, R5, R6, R7, R13, R14, R15, R16, R17, R21a and R21b are as defined herein. The compounds are of particular use in the treatment or prevention of depression, anxiety, pain, inflammation, migraine, emesis or postherpetic neuralgia.