3346-63-2

Basic information

• Product Name: TERT-BUTYL CARBAZATE
• Synonyms: (6-amino-3-nitro-2-pyridyl)amine;2,6-Diamino-3-nitropyridine;3-Nitro-2,6-pyridinediamine;2,6-Pyridinediamine, 3-nitro-
• CAS NO: 3346-63-2
• Molecular Formula: C₅H₆N₄O₂
• Molecular Weight: 132.16
• EINECS: 1533716-785-6
• Mol File: 3346-63-2.mol
• Article Data: 10

Chemical Properties

• Melting Point: 230℃
• Boiling Point: 303.6 °C at 760 mmHg
• Flash Point: 94.7 °C
• Appearance: Yellow crystal powder
• Density: 1.555
• Vapor Pressure: 7.76E-08mmHg at 25°C
• Refractive Index: 1.725
• CAS DataBase Reference: TERT-BUTYL CARBAZATE(CAS DataBase Reference)
• NIST Chemistry Reference: TERT-BUTYL CARBAZATE(3346-63-2)
• EPA Substance Registry System: TERT-BUTYL CARBAZATE(3346-63-2)

Safety Data

• Hazardous Substances Data: 3346-63-2(Hazardous Substances Data)

Usage

InChI:InChI=1/C5H6N4O2/c6-4-2-1-3(9(10)11)5(7)8-4/h1-2H,(H4,6,7,8)

Upstream product

• 89323-10-4 2,6-diamino-3-nitrosopyridine 
• 4214-75-9 2-amino-3-nitropyridine 
• 857992-18-8 6-ethoxy-2-bromo-3-nitro-pyridine 
• 2530-26-9 3-nitropyridine 
• 27048-04-0 2-amino-6-chloro-3-nitropyridine 
• 500589-17-3 N,N′-(3-nitropyridine-2,6-diyl)diacetamide 
• 5441-02-1 N,N'-(2,6-pyridinediyl)bis(acetamide) 
• 141-86-6 2.6-diaminopyridine 
• 16013-85-7 2,6-dicholoro-3-nitropyridine 
• 4645-11-8 6-ethoxy-2-bromo-pyridine 
• 64-17-5 ethanol 
• 7803-49-8 hydroxylamine 
• 7664-41-7 ammonia 
• 7722-84-1 dihydrogen peroxide 

Downstream Products

• 118020-75-0 6-nitro-thiazolo[4,5-b]pyridine-2,5-diyldiamine 
• 4318-79-0 2,3,6-triaminopyridine 
• 147408-05-7 2-n-Propyl-5-n-butyrylamino-imidazo[4,5-b]pyridine 
• 108676-56-8 N,N',N''-thiazolo[4,5-b]pyridine-2,5,6-triyl-tris-acetamide 
• 119151-74-5 2-amino-5,8-dihydro-thiazolo[5',4':5,6]pyrido[2,3-b]pyrazine-6,7-dione 
• 119151-73-4 thiazolo[5',4':5,6]pyrido[2,3-b]pyrazin-2-ylamine 
• 412307-90-5 thiazolo[4,5-b]pyridine-2,5,6-triyltriamine 

Relevant articles and documents

Novel nucleoside analogues targeting HCV replication through an NS5A-dependent inhibition mechanism

A series of new tricyclic nucleosides were synthesized and evaluated as hepatitis C virus (HCV) replication inhibitors. Initial screening in a HCV replicon system, derived from a genotype 1b isolate, identified 9-benzylamino-3-(β-D-ribofuranosyl)-3H-imidazo[4′,5′:5,6]pyrido[2,3-b]pyrazine (15d) as the most potent analogue. Comparative assessment of 15d activity against HCV full-length viruses or subgenomic replicons derived from genotypes 1 to 4 revealed a specificity of the compound for genotypes 1 and 3. Surprisingly, resistance mutations selected against 15d were mapped to domains II and III of the non-structural protein 5A (NS5A), but not to the RNA-dependent RNA polymerase residing in NS5B. These results argue that compound 15d might represent a lead for the development of a novel class of NS5A inhibitors.

p38α AUTOPHOSPHORYLATION INHIBITORS

The present invention concerns inhibitors of p38α autophosphorylation, pharmaceutical compositions comprising them, and their use in the treatment of a number of diseases, such as myocardial ischemia reperfusion injury. The inhibitors satisfy the following general formula: wherein R, R1, R2, R4, and R5 may have different meanings.

A practical synthesis of substituted 2,6-diaminopyridines via microwave-assisted copper-catalyzed amination of halopyridines

A microwave assisted copper-catalyzed amination protocol is reported utilizing a series of 2,6-dihalo- and 2-amino-6-halo pyridine precursors. Using this procedure, selective substitution of one or two halogens by aryl or alkylamines was achieved within 2-6 h with temperatures between 80 and 225 °C affording 2,6-diaminopyridines in good to excellent isolated yields. The reaction allows easy variation between educts and different N-substitutions. The target compounds are valuable precursors for the synthesis of bis-phosphorylated 2,6-diaminopyridines which are used as PNP pincer ligands in transition metal complexes.