335-42-2

Basic information

• Product Name: HEPTAFLUOROBUTYRYL FLUORIDE
• Synonyms: HEPTARFLUOROBUTYRYL FLUORIDE;HEPTAFLUOROBUTYRYL FLUORIDE;heptafluoro-butanoylfluorid;perfluorobutyryl fluoride;HEPTAFLUOROBUTYRYL FLUOROIDE;Heptafluorobutyric acid fluoride;2,2,3,3,4,4,4-heptafluorobutanoyl fluoride;2,2,3,3,4,4,4-heptafluorobutyryl fluoride
• CAS NO: 335-42-2
• Molecular Formula: C₄F₈O
• Molecular Weight: 216.03
• EINECS: 206-390-0
• Mol File: 335-42-2.mol
• Article Data: 19

Chemical Properties

• Boiling Point: 7-9°C
• Flash Point: °C
• Appearance: /
• Density: 1.595g/cm³
• Vapor Pressure: 808mmHg at 25°C
• Refractive Index: 1.255
• CAS DataBase Reference: HEPTAFLUOROBUTYRYL FLUORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: HEPTAFLUOROBUTYRYL FLUORIDE(335-42-2)
• EPA Substance Registry System: HEPTAFLUOROBUTYRYL FLUORIDE(335-42-2)

Safety Data

• Hazard Codes: C
• Statements: 34
• Safety Statements: 26-36/37/39-45
• RIDADR: 3308
• TSCA: T
• HazardClass: GAS, CORROSIVE
• Hazardous Substances Data: 335-42-2(Hazardous Substances Data)

Usage

General Description

Heptafluorobutyryl fluoride, also known as HFBBF, is a fluorocarbon compound that is used as a building block in the production of various fluorochemicals. It is a colorless and volatile liquid with a pungent odor, and it is highly reactive due to the presence of the fluorine atoms in its structure. Heptafluorobutyryl fluoride is primarily used as a reagent in the synthesis of pharmaceuticals, agrochemicals, and materials with specific fluorinated functionalities. It is also used as a key intermediate in the manufacturing of fluorinated polymers, surfactants, and specialty chemicals. However, it is important to handle this chemical with caution, as it is hazardous if ingested, inhaled, or comes in contact with the skin or eyes.

InChI:InChI=1/C4F8O/c5-1(13)2(6,7)3(8,9)4(10,11)12

Upstream product

• 107-92-6 butyric acid 
• 79-53-8 chloropentafluoroacetone 
• 143813-70-1 Perfluoro-cis-2-n-butyl-3-n-propyloxaziridine 
• 118361-35-6 α-Chlorohexafluorobutyryl fluoride 
• 225792-85-8 Fluorosulfuric acid 2,3,4,4,4-pentafluoro-2-fluorosulfonyloxy-1-heptafluoropropyl-1,3-bis-trifluoromethyl-butyl ester 
• 78-93-3 butanone 
• 694-02-0 cyclopropane carboxylic acid fluoroanhydride 
• 118361-32-3 1,2-epoxy-2-chloroheptafluorobutane 
• 3709-90-8 1,2-epoxy-1,1,2,3,3,4,4,4-octafluorobutane 
• 83305-86-6 perfluorobutyrylfluorosulfonylfluoroacetyl fluoride 
• 127-21-9 1,3-dichloro-1,1,3,3-tetrafluoro-propan-2-one 
• 72844-35-0 2,2,3,3,4,4,4-Heptafluoro-butyric acid 2-chloro-1,1,2,2-tetrafluoro-ethyl ester 
• 72844-36-1 2,2,3,3,4,4,4-Heptafluoro-butyric acid 2-chloro-1,1-difluoro-ethyl ester 
• 353-50-4 Carbonyl fluoride 

Downstream Products

• 336-61-8 2,2,3,3,4,4,4-heptafluoro-N-phenylbutanamide 
• 813-45-6 2H-undecafluoro-2-trifluoromethyl-hexan-3-one 
• 358-74-7 diethyl fluorophosphate 
• 78-40-0 triethyl phosphate 
• 80982-75-8 diethyl ester of pentafluoroisopropenylphosphonic acid 
• 356-27-4 ethyl heptafluorobutyrate 
• 464-40-4 [3-(2,2,3,3,4,4,4-heptafluorobutanoyloxy)-2,2-bis(2,2,3,3,4,4,4-heptafluorobutanoyloxymethyl)propyl] 2,2,3,3,4,4,4-heptafluorobutanoate 
• 163702-07-6 methyl nonafluorobutyl ether 
• 355-42-0 tetradecafluorohexane 
• 2110-93-2 <4-Perfluor-heptyl>-perfluorpropyl-aether 
• 308-67-8 heptafluoro-butyric acid-(4-bromo-anilide) 
• 662-50-0 heptafluorobutyramide 
• 375-22-4 heptafluorobutyric Acid 
• 356-24-1 methyl heptafluorobutyrate 

Relevant articles and documents

THE FACILE PREPARATION OF HF FREE POLYFLUORINATED ACYL FLUORIDES

The reaction of polyfluorinated acids with the Ishikawa Reagent (FAR) in the presence of NaF gives 59 - 91 percent isolated yields of HF free polyfluorinated acyl fluorides.The reaction is rapid, safe, easily scaled up, and amenable to a one-pot procedure.

Method for preparing perfluoroisobutyryl fluoride by reaction kettle liquid-phase method

The invention belongs to the field of fluorine chemical industry, and particularly relates to a method for preparing perfluoroisobutyryl fluoride by a reaction kettle liquid-phase method; the perfluoroisobutyryl fluoride is prepared with hexafluoropropylene and carbonyl fluoride as raw materials and a 2-perfluoroalkylbenzothiazole compound as a catalyst. Compared with a traditional reaction kettleliquid-phase one-pot method for preparing perfluorobutyryl fluoride, the method has the advantages that the 2-perfluoroalkylbenzothiazole compound is used as the catalyst, can be dissolved in an acetonitrile solvent and is uniformly coated around the raw material hexafluoropropylene, and the electron donor and acceptor properties of the perfluorobutyryl fluoride can tightly combine carbonyl fluoride free radicals, hexafluoropropylene free radicals and isobutyryl fluoride free radicals generated under an alkaline condition, so as to be beneficial to shortening the reaction time.

Heptafluorobutyric acid and preparation method of derivative thereof

The invention provides a preparation method of heptafluorobutyric acid. The preparation method comprises the following steps: (A) carrying out an electrochemical fluoridation reaction on n-butyric acid, n-butyryl chloride or n-butyryl fluoride with anhydrous hydrogen fluoride, thus obtaining an electrolytic mixed gas, wherein the current density of the electrochemical fluoridation reaction is 0.025 to 0.033 A/cm, and the reaction temperature is 9 to 13 DEG C; a cooling reflux device is arranged in the electrochemical fluoridation reaction, and the temperature of a cooling medium of the cooling reflux device is -45 DEG C; (B) pumping the electrolytic mixed gas obtained in the step (A) into a reaction kettle filled with an acid-binding agent, thus obtaining heptafluorobutyryl fluoride, wherein the acid-binding agent is triethylamine; (C) mixing the heptafluorobutyryl fluoride obtained in the step (B) with water, and hydrolyzing, thus generating a heptafluorobutyric acid water solution; (D) mixing the heptafluorobutyric acid water solution with KOH, and naturally crystallizing until the concentration of the KOH is 40 to 45 percent, thus obtaining potassium heptafluorobutyrate; (E) acidizing the potassium heptafluorobutyrate by using sulfuric acid, thus obtaining the heptafluorobutyric acid.