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335-67-1

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335-67-1 Usage

Description

Concerns about the potential environmental and toxicological impacts of long-chain perfluoroalkyl sulfonates and carboxylic acids have led to: (1) the phaseout of production of perfluorooctane sulfonate (PFOS) and related compounds and perfluorooctanoic acid (PFOA) by their major global manufacturer in 2000–02; (2) the conclusion of a stewardship agreement between the United States Environmental Protection Agency (US EPA) and eight leading global companies to reduce emissions and product content of PFOA and related chemicals by 95% by 2010 and to work toward their elimination by 2015; (3) a similar agreement between the Canadian environmental and health authorities and five companies to restrict perfluorinated carboxylic acids in products; (4) a European Union Marketing and Use Directive restricting the use of ‘PFOSs’ in the European Union; and (5) the inclusion of PFOS in the Stockholm Convention on Persistent Organic Pollutants as an Annex B substance, i.e., restricted in its use; and other regulatory and voluntary initiatives intended to reduce environmental emissions of this family of compounds.

Chemical Properties

Perfluorooctanoic acid is a white to off-white powder or colorless flakes. It is very soluble in water.It has a pH of 2.6. Perfluorooctanoic acid has the ability to react with bases, oxidizing agents, and reducing agents. Upon decomposition, PFOA can form carbon oxides and hydrogen fluoride. Additional information related to physical and chemical properties of PFOA are not currently available.

Uses

Different sources of media describe the Uses of 335-67-1 differently. You can refer to the following data:
1. Perfluorooctanoic acid (PFOA) is fluorinated surfactant used, primarily as its ammonium salt (APFO), as an aid in the chemical synthesis of fluoropolymers and fluoroelastomers. As such, it may be found in nonstick cookware and utensils, stain-repellant fabric treatments, and water-proofing treatments for garments. Although an effort is underway by the U.S. EPA to reduce use of and replace perfluoroalkyls with other substances, PFOA is still used in United States industry. Perfluorooctanoic acid (PFOA, C8, pentadecafluorooctanoic acid, perfluoro caprylic acid) is an eightcarbon compound in the perfluoroalkyl family of chemicals. Perfluorooctane sulfonate is used in a variety of applications, including nonstick cookware, waterproof clothing, leather products, cleaning products, and pesticides. Its main use was as a stain repellent on carpet, furniture, and other consumer products. In 2006, the U.S. Protection Agency along with eight major companies that utilized PFOA embarked on a program to reduce emissions and use of the chemical by 2015 (USEPA, 2012).
2. PFOA is a completely fluorinated organic acid that is produced synthetically as its salts. The typical structure has a nonbranched chain of eight carbon atoms. The industrial production of perfluoroalkyl carboxylates started in the late 1940s. Two principal production processes are used to manufacture PFOA, viz. electrochemical fluorination and telomerization. PFOA can also appear as a result of degradation of some precursors, e.g., fluorotelomer alcohols. The ammonium salt of PFOA is primarily used as an emulsifier or ‘processing aid’ in industrial applications, for example, in the production of fluoropolymers such as polytetrafluoroethylene, but also produced for fluorosurfactant use. Typical uses include fluoropolymers in electronics, textiles, and nonstick cookware, and fluorosurfactants in aqueous filmforming foams used for fire fighting.
3. Pentadecafluorooctanoic acid solution may be used as an ion-pairing reagent in the development of a chromatographic method for the separation and determination of underivatized proteinic amino acids using liquid chromatography with evaporative light scattering detection (LC-ELSD) and atmospheric pressure ionization-mass spectrometry (LC-API-MS), respectively.

Definition

ChEBI: A fluoroalkanoic acid that is perfluorinated octanoic acid.

General Description

Perfluorooctanoic acid is a perfluoroalkyl acid commonly used in the preparation of fluoroacrylic esters, fluoropolymers and fluoroelastmers. It is found to be environmentally persistent and bioaccumulative with a long half-life.

Safety Profile

Poison by intraperitoneal route. Mutation data reported. Whenheated to decomposition it emits toxic vapors of Fí.

Environmental Fate

Perfluorooctanoic acid found in the environment may result from waste stream releases from manufacture of cosmetics, lubricants, paints, polishes, adhesives, fabric treatments, and fire-fighting compounds. It can partition to the vapor phase in the atmosphere, where it is degraded atmospherically with a half-life of 31 days. It is very resistant to hydrolysis, and immobile in soil. It will not likely evaporate from soil (depending on soil pH) or surface waters. It is not expected to be absorbed to sediments and suspended particles. Perfluorooctanoic acid is not expected to bioaccumulate in aquatic organisms (BCF =3.1–9.4) (NLM, 2013).

Purification Methods

Crystallise the acid from CCl4 and toluene, and distil it. It forms micelles in H2O and the solubility is 1% in H2O. The acid chloride has b 129-130o/744mm. The amide has m 138o. [Bernett & Zisman J Phys Chem 63 1911 1959, Bro & Sperati J Polym Sci 38 289 1959, Beilstein 2 IV 994.]

Toxicity evaluation

Studies with animals fed PFOA for a long period showed effects on the stomach, liver, and thyroid hormones. Animal studies also indicate that PFOA may cause cancer at relatively high levels. PFOA has also been shown to be a developmental toxicant, and to have effects on the immune system. PFOA affects primarily the liver and can cause developmental and reproductive toxic effects at relatively low dose levels in experimental animals. It increases the tumor incidence in rats, mainly in the liver. The carcinogenic effects in rats appear to be due to indirect/nongenotoxic modes of action. Epidemiological studies in PFOA-exposed workers do not indicate an increased cancer risk. There is relatively consistent evidence of modest positive associations between serum levels of PFOA and cholesterol, uric acid, and liver enzyme levels. The critical effects observed in rodents and monkeys are on the liver and include hypertrophy, changes in liver enzyme activity, and proliferation of peroxisomes. In rodents the anionic form of PFOA induces hepatocellular adenomas, Leydig cell adenomas, and pancreatic hyperplasia. The genotoxic activity of PFOA is a matter of current debate and controversy, with classifications as ‘devoid of significant genotoxicity’ as well as ‘weakly nonspecific genotoxic.’ PFOA does not appear directly genotoxic; animal data indicate that it can cause several types of tumors and neonatal death and may have toxic effects on the immune, liver, and endocrine systems.

Check Digit Verification of cas no

The CAS Registry Mumber 335-67-1 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 3,3 and 5 respectively; the second part has 2 digits, 6 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 335-67:
(5*3)+(4*3)+(3*5)+(2*6)+(1*7)=61
61 % 10 = 1
So 335-67-1 is a valid CAS Registry Number.

335-67-1 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
  • Packaging
  • Price
  • Detail
  • TCI America

  • (P0764)  Pentadecafluorooctanoic Acid  >98.0%(T)

  • 335-67-1

  • 10g

  • 590.00CNY

  • Detail
  • TCI America

  • (P0764)  Pentadecafluorooctanoic Acid  >98.0%(T)

  • 335-67-1

  • 25g

  • 1,200.00CNY

  • Detail
  • Alfa Aesar

  • (L08862)  Perfluorooctanoic acid, 95%   

  • 335-67-1

  • 5g

  • 267.0CNY

  • Detail
  • Alfa Aesar

  • (L08862)  Perfluorooctanoic acid, 95%   

  • 335-67-1

  • 25g

  • 955.0CNY

  • Detail
  • Sigma-Aldrich

  • (33824)  Pentadecafluorooctanoicacid  analytical standard

  • 335-67-1

  • 33824-100MG

  • 934.83CNY

  • Detail
  • Sigma-Aldrich

  • (33603)  Pentadecafluorooctanoicacidsolution  100 μg/mL in methanol, analytical standard

  • 335-67-1

  • 33603-1ML

  • 1,062.36CNY

  • Detail
  • Aldrich

  • (171468)  Perfluorooctanoicacid  96%

  • 335-67-1

  • 171468-5G

  • 466.83CNY

  • Detail
  • Aldrich

  • (171468)  Perfluorooctanoicacid  96%

  • 335-67-1

  • 171468-25G

  • 1,781.91CNY

  • Detail

335-67-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017

1.Identification

1.1 GHS Product identifier

Product name perfluorooctanoic acid

1.2 Other means of identification

Product number -
Other names A 5717

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only. Intermediates
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:335-67-1 SDS

335-67-1Relevant articles and documents

A rationally designed perfluorinated host for the extraction of PFOA from water utilising non-covalent interactions

Omorodion, Harrison,Palenzuela, Miguel,Ruether, Manuel,Twamley, Brendan,Platts, James A.,Baker, Robert J.

, p. 7956 - 7968 (2018)

Perfluorooctanoic acid (PFOA) is a persistent organic pollutant and widespread in the environment. Three hosts have been synthesized based upon the formation of a fluorous cavity and hydrogen bonding receptors with the aim of extracting PFOA from water into organic solvents. The hosts based upon a calix[4]arene functionalized at the lower rim with amide groups and fluorous ponytails are effective for the quantitative removal of PFOA. Modification to a partial cone or a trisaminoamine framework reduces the conformational rigidity and lowers the extraction efficiency. A comprehensive NMR spectroscopic analysis both in solution and the solid state, along with other characterization techniques, has elucidated the stoichiometry of the host:guest species and the binding constants have been measured. A computational study has given further insight into the binding modes and corroborated the spectroscopic measurements.

Preparation method of fluorine-containing carboxylic acid

-

Paragraph 0056-0058, (2020/07/12)

The invention discloses a preparation method of fluorine-containing carboxylic acid. The method comprises the following steps: reacting fluorine-containing carboxylate used as a raw material with an acylating chlorination reagent to obtain a corresponding mixture of fluorine-containing acyl chloride and fluorine-containing anhydride, and hydrolyzing and drying the mixture of fluorine-containing acyl chloride and fluorine-containing anhydride to obtain high-purity fluorine-containing carboxylic acid. The method provided by the invention is suitable for post-treatment of fluorine-containing carboxylic acid prepared by a fluorine-containing olefin (monoolefine, diene, cycloolefin and the like) oxidation method, replaces the traditional strong acid acidification and ether continuous extractionprocess, and is simpler, more convenient and more applicable; and the method can also be used for recovering and purifying a fluorine-containing carboxylate emulsifier. The purity of the fluorine-containing carboxylic acid prepared by the method can reach 98% or above.

Hydrolysis of p-nitrophenyl perfluoroctanoate in mixed surfactant systems

Torres, Maria Florencia,De Rossi, Rita H.,Fernandez, Mariana A.

, p. 28606 - 28614 (2014/07/22)

The kinetics of the hydrolysis reaction of p-nitrophenyl perfluoroctanoate were studied in the presence of different amphiphilic systems: two hydrocarbon surfactants (sodium dodecyl sulfate, SDS, and polyoxyethylene(23)lauryl ether, Brij-35), a perfluorinated detergent (perfluorononanoic acid, PFNA) and in mixtures of SDS-PFNA and Brij-35-PFNA. The study was performed at different compositions of the mixtures (characterized by the molar fraction of PFNA, αPFNA), and for each αPFNA the concentration was varied over a wide range. The kinetic probe p-nitrophenyl perfluoroctanoate showed a very strong interaction with the surfactants. In the presence of the mixed surfactants, the behaviour of the probe changed dramatically with the composition of the mixtures, which indicates that this substrate is very sensitive to the effect of the micellar media, being a very good molecule to study these types of surfactant systems. The use of the studied ester allowed us to confirm the presence of two different aggregates in the mixture Brij-35-PFNA as was previously observed with other techniques. The presence of hydrocarbon-rich micelles at low αPFNA, as well as perfluorinated rich micelles at high αPFNA was also confirmed. The kinetic behaviour of p-nitrophenyl perfluoroctanoate in SDS-PFNA mixtures fully agreed with our previous description of the aggregates formed in this system. The presence of a practically pure PFNA micelle at high αPFNA could be also demonstrated from the kinetic results.

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