33515-43-4

Upstream product

• 35779-32-9 1,3,5-tris(4-methylphenyl)-2,4-diazapenta-1,4-diene 
• 3839-31-4 dimethyl(phenyl)silyllithium 
• 104-85-8 para-methylbenzonitrile 
• 104-87-0 4-methyl-benzaldehyde 
• 3457-48-5 1,2-di(4-methylphenyl)-1,2-ethanedione 
• 1218-89-9 4,4'-dimethylbenzoin 
• 104-84-7 para-methylbenzylamine 
• 108-88-3 toluene 
• 102747-54-6 2,4,5-tri-p-tolyl-4,5-dihydro-1H-imidazole 

Relevant academic research and scientific papers

Preparation method for 2,4,5-trisubstituted imidazole compound

The invention relates to a preparation method for 2,4,5-trisubstituted imidazole. According to the method, benzylamine is used as a substrate, and ZnIn2S4 is used as a photocatalyst; and under the condition of illumination of visible light, benzylamine un

Photocatalytic coupling of amines to imidazoles using a Mo-ZnIn2S4 catalyst

Substituted imidazoles are traditionally synthesized by co-condensation of multiple feedstocks. Herein, we report a new route for the synthesis of substituted imidazoles via photocyclization of readily available amines at room temperature. The reaction is achieved by the visible-light-induced C-C/C-N bond coupling and subsequent dehydrogenation reaction over Mo-ZnIn2S4 as a heterogeneous photocatalyst. A wide range of amines were converted into the corresponding tri- and tetra-substituted imidazoles with up to 96% total yields. The simplicity, high efficiency and mild condition merits of this new reaction will enable it to be useful in synthetic transformations.

Efficient synthesis of 2,4,5-triaryl-1H-imidazoles from aromatic aldehydes with HMDS catalyzed by N-bromosaccharin (NBSa)

A one-pot efficient procedure for the synthesis of 2, 4, 5-triaryl-1H-imidazole derivatives by the reactions of hexamethyldisilazane and arylaldehydes in the presence of N-bromosaccharin (NBSa) is studied. This new method offers several advantages, such as excellent yields, easy workup, short reaction times, and simple procedure.

One-pot, simple and efficient synthesis of triaryl-1h-imidazoles by kmno4/cuso4

ABSTRACT 2,4,5-Triarylimidazoles have been obtained in excellent yields by the one-pot three-component condensation of bis-aryl a-hydroxyketones, aromatic aldehydes and ammonium acetate by the action of inexpensive, readily available and nontoxic KMnO4/CuSO4 under mild reaction conditions. The present method is simple, efficient, cost-effective and eco-friendly.

Convenient one-pot synthesis of 2,4,5-triaryl-1H-imidazoles from arylaldehydes, benzyl alcohols, or benzyl halides with HMDS in the presence of molecular iodine

A one-pot efficient procedure for the synthesis of 2,4,5-triaryl-1 H-imidazole derivatives in good to excellent yields by reaction between hexamethyldisilazane and arylaldehydes, benzyl alcohols, benzyl halides in the presence of molecular iodine has been developed. The remarkable advantages of this method are the simple workup procedure, high yields of products, and the availability of reagents.

One-pot synthesis of polysubstituted imidazoles from arylaldehydes in water catalyzed by nhc using microwave irradiation

A simple, high yielding synthesis of tri (3a-i) and tetrasubstituted (4a-g) imidazols from aldehydes is described. The cornerstone of this methodology involves the condensation of NH4OAc, substituted aldehydes, and benzoin, which is synthesized in situ from aldehydes catalyzed by N-heterocyclic carbine (NHC), under microwave irradiation in water to afford trisubstituted imidazoles (3a-i). If arylamine is added in the solution, tetrasubstituted imidazoles (4a-g) can be obtained. Lepidilines B and trifenagrel are also synthesized in high yield using this procedure. All the experiment deta are in agreement with the literature.

One-pot synthesis of 2,4,5-triaryl-1 H -imidazoles from arylaldehydes, benzyl alcohols, or benzyl halides with hexamethyldisilazane in molten tetrabutylammonium bromide

A simple and efficient method for the synthesis of 2,4,5-triaryl-1H- imidazole derivatives in good to excellent yields by reaction between hexamethyldisilazane and arylaldehydes, benzyl alcohols, benzyl halides in molten tetrabutylammonium bromide as an inexpensive and non toxic solvent has been developed. The remarkable advantages of this method are the simple workup procedure, high yields of products, the use of an ionic liquid as a green solvent, and the availability of reagents. Georg Thieme Verlag Stuttgart - New York.

One-pot synthesis of imidazoles from aromatic nitriles with nickel catalysts

Nickel(0) catalysts were used to produce substituted imidazoles in good to high yields using benzonitrile, p-substituted benzonitriles and 4-cyanopyridine as starting materials. The Royal Society of Chemistry 2011.

Facile method for one-step synthesis of 2,4,5-triarylimidazoles under catalyst-free, solvent-free, and microwave-irradiation conditions

A green and efficient method for the synthesis of 2,4,5-triarylimidazoles by one-step condensation reaction of benzil, aromatic aldehyde, and ammonium acetate under catalyst-free, solvent-free, and microwave-irradiation conditions is reported. This method had many dramatic advantages, such as the short reaction time (3-5min), good yields (80-99%), environmental friendliness, and convenient operation.

Application of alkali metal hydrides of nanometric size in reduction, cyclotrimerization and metalation

Reactions of some representative organic functional compounds by the alkali metal hydrides of nanometric size have been studied. Nitrobenzene, some aldehydes, esters and organic halides are reduced with good yield and high selectivity in many cases. Nitriles are cyclotrimerized and dimethyl sulfoxide is rapidly deprotonated.