33581-95-2

Usage

InChI:InChI=1/C4H10ClNO2S/c1-4(2,3)6-9(5,7)8/h6H,1-3H3

Upstream product

• 10017-37-5 tert-butylamine hydrochloride 
• 75-64-9 tert-butylamine 
• 1189-71-5 isocyanate de chlorosulfonyle 
• 75-65-0 tert-butyl alcohol 

Downstream Products

• 49689-93-2 C₁₁H₁₈N₂O₃S 
• 49689-96-5 C₁₂H₂₀N₂O₂S 
• 49689-95-4 C₁₀H₁₄Cl₂N₂O₂S 
• 815-24-7 Di-t-butyl ketone 
• 38662-39-4 t-butyl-N-sulfinylamine 
• 105168-41-0 C₁₀H₁₆N₄O₄S 
• 123568-49-0 n-tert-butyl-N'-<1,1-diphenyl-1-(methoxycarbonyl)methyl>sulfamide 
• 75-97-8 3,3-dimethyl-butan-2-one 
• 78077-07-3 tert-Butyl-[1,2,2-trimethyl-prop-(E)-ylidene]-amine 
• 68256-21-3 N-<(1-ethyl-2-pyrrolidinyl)methyl>-2-methoxy-4-methyl-5-<(tert-butylsulfamoyl)amino>benzamide 
• 90763-40-9 C₂₀H₃₄N₄O₄S 
• 90763-42-1 C₂₀H₃₃ClN₄O₄S 
• 486-25-9 9-fluorenone 
• 64605-49-8 N-t-Butylfluorenimin 

Relevant academic research and scientific papers

Strongly UV absorbing bifunctional azoalkanes

(Figure Presented) Two new anthracene-containing azoalkanes (1 and 2) absorb UV light 600 times more strongly than simple azoalkanes. Intramolecular energy transfer from excited singlet anthracene to the azo group is nearly complete, but despite the close proximity of the two chromophores, 1 and 2 continue to exhibit anthracene fluorescence. Thermolysis of these compounds in the presence of monomers affords fluorescent labeled polymers. Compounds 1 and 2 are the first azoalkanes to undergo induced decomposition in solution.

Synthesis of N-Substituted Sulfamate Esters from Sulfamic Acid Salts by Activation with Triphenylphosphine Ditriflate

A general approach to access sulfamate esters through preparation of sulfamic acid salts, subsequent activation with triphenylphosphine ditriflate, and nucleophilic trapping is disclosed. The method proceeds in modest to excellent yields to incorporate nucleophiles derived from aliphatic alcohols and phenols. This approach can be employed to furnish differentially substituted sulfamides.

Synthesis of α-alkylated γ-butyrolactones with concomitant anhydride kinetic resolution using a sulfamide-based catalyst

The Kinetic Resolution (KR) of α-alkylated enolisable disubstituted anhydrides has been shown to be possible for the first time. In the presence of an ad hoc designed novel class of bifunctional sulfamide organocatalyst, a regio-, diastereo- and enantioselective cycloaddition reaction between the enolisable anhydride and benzaldehydes provides densely functionalised γ-butyrolactones in one pot (up to 19:1 dr, 94% ee) with control over three contiguous stereocentres. The concomitant resolution of the starting material anhydride, provides access to a range of chiral succinate derivatives with selectivity factors up to S? = 10.5.

NOVEL FLUORINATED CYCLIC SULFAMIDES EXHIBITING NEUROPROTECTIVE ACTION AND THEIR METHOD OF USE

Pharmaceutical compositions of the invention include substituted fluorinated cyclic sulfamide derivatives having a disease-modifying action in the treatment of diseases associated with excitotoxicity and accompanying oxidative stress that include epilepsy

PYRROLO SULFONAMIDE COMPOUNDS FOR MODULATION OF ORPHAN NUCLEAR RECEPTOR RAR-RELATED ORPHAN RECEPTOR-GAMMA (RORGAMMA, NR1F3) ACTIVITY AND FOR THE TREATMENT OF CHRONIC INFLAMMATORY AND AUTOIMMUNE DISEASES

The invention provides modulators for the orphan nuclear receptor RORy and methods for treating RORy mediated diseases by administrating these novel RORy modulators to a human or a mammal in need thereof. Specifically, the present invention provides pyrrolo sulfonamide compounds of Formula (1) and the enantiomers, diastereomers, tautomers, solvates and pharmaceutically acceptable salts thereof.

An improved procedure for the synthesis of 4,4-disubstituted-3-oxo-1,2,5-thiadiazolidine 1,1-dioxides

An improved synthesis for the preparation of 3-oxo-1,2,5-thiadiazolidine 1,1-dioxides has been developed. This facile two-step procedure from α-amino acid esters and chlorosulfonyl isocyanate results in excellent yields of products.

Thiaziridine 1,1-Dioxides

Experiments towards a 1,3-elimination of hydrogen halides from α-chlorosulfonamides, α-bromosulfonamides, and N-chlorosulfonamides did not yield isolable thiaziridine 1,1-dioxides 4.Therefore, at -78 deg C, the diazoalkanes 10 were allowed to react with N-sulfonylamines 14 generated in situ by hydrogen chloride elimination from sulfamoylchlorides with triethylamine.If the work-up temperature was kept below -30 deg C, from tert-alkyldiazomethanes and tert-alkylsulfamoylchlorides the 2,3-di-tert-alkylthiaziridine 1,1-dioxides 4f - i were obtained in 32 - 47 percent yield.They form colorless, thermally labile crystals.Their structure was based on IR, UV and 1H-NMR spectra as well as on the quantitative thermal decomposition into sulfur dioxide and aldimines.The disubstituted diazomethanes 23 reacted with tert-butylsulfonylamine affording, besides N-tert-butylketimines (the decomposition products of intermediate trisubstituted thiaziridine 1,1-dioxides 21), tert-butylsulfinylamine 25 and ketones 26.The latter products presumably resulted from the cheletropic decomposition of the oxathiiranes 24.

Thiadiaziridine 1,1-Dioxides: Synthesis and Chemistry

The synthesis and chemical reactions of a series of thiadiaziridine 1,1-dioxides (2) are described.The thermal stability is highly dependent on the R group and in one case (R = tert-octyl) is postulated that the thermolysis initially produces a diradical intermediate which can be trapped or further fragments to give a nitrene.A temperature-dependent NMR study on the coalescence of the diastereotopic α-methyl protons of 2b gives a ΔG = 20 kcal*mol-1.

N-pyrazinecarbonyl-N'-substituted-sulfamoylguanidine and processes for preparing same

The case involves novel N-pyrazinecarbonyl-N'-substituted-sulfamoylguanidine and processes for preparing same. The N-pyrazinecarbonyl-N'-substituted-sulfamoylguanidines are excellent eukalemic agents possessing diuretic and natriuretic properties.