33675-75-1

Basic information

• Product Name: 3-PHENETHYL-PHENOL
• Synonyms: 3-PHENETHYL-PHENOL;PHENOL,3-(2-PHENYLETHYL)-;1-(3-Hydroxyphenyl)-2-phenylethane;3-(2-phenylethyl)phenol
• CAS NO: 33675-75-1
• Molecular Formula: C₁₄H₁₄O
• Molecular Weight: 198.26036
• Mol File: 33675-75-1.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 319.7 °C at 760 mmHg
• Flash Point: 151.6 °C
• Appearance: /
• Density: 1.093 g/cm³
• Vapor Pressure: 0.000178mmHg at 25°C
• Refractive Index: 1.601
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 3-PHENETHYL-PHENOL(CAS DataBase Reference)
• NIST Chemistry Reference: 3-PHENETHYL-PHENOL(33675-75-1)
• EPA Substance Registry System: 3-PHENETHYL-PHENOL(33675-75-1)

Safety Data

• Hazardous Substances Data: 33675-75-1(Hazardous Substances Data)

Usage

General Description

3-Phenethyl-phenol, also known as 3-phenethylphenol or 3-PEP, is a chemical compound with the formula C14H14O. It is a white crystalline powder with a faint floral odor, and it is commonly used as a preservative and antiseptic agent in various personal care and cosmetic products, as well as in food packaging. 3-Phenethyl-phenol has antimicrobial properties and is effective against a wide range of bacteria and fungi, making it a valuable ingredient in products such as mouthwash, hand sanitizers, and cleaning solutions. It is also used in the preservation of industrial products such as metalworking fluids and surfactants. Additionally, 3-Phenethyl-phenol has been investigated for its potential as an anti-cancer and anti-inflammatory agent, showing promise in preclinical studies. However, it is important to note that it can cause skin and eye irritation in high concentrations and should be used with caution.

InChI:InChI=1/C14H14O/c15-14-8-4-7-13(11-14)10-9-12-5-2-1-3-6-12/h1-8,11,15H,9-10H2

Upstream product

• 76425-88-2 3-hydroxystilbene 
• 1449-46-3 benzyltriphenylphosphonium bromide 
• 22115-41-9 2-(bromomethyl)benzonitrile 
• 5505-00-0 2-(2-Phenethyl)benzonitrile 
• 100-42-5 styrene 
• 739-58-2 4-(N,N-Dimethylamino)triphenylphosphine 
• 536-74-3 phenylacetylene 
• 626-02-8 3-Iodophenol 
• 14064-41-6 1-methoxy-3-styrylbenzene 
• 57234-27-2 1-(methoxymethoxy)-3-methylbenzene 
• 108-88-3 toluene 
• 100-44-7 benzyl chloride 
• 13246-50-9 benzylchlorotriphenylphosphorane 
• 108-39-4 3-methyl-phenol 

Downstream Products

• 127003-24-1 3-(4-dimethylaminobutoxy)bibenzyl 

Relevant articles and documents

Combined Cyanoborylation, C-H Activation Strategy for Styrene Functionalization

A one-pot multicomponent copper-catalyzed protocol for borylation/ortho-cyanation of styrene derivatives followed by a Suzuki-Miyaura coupling provides a platform to explore the factors that control the selectivity between distal or proximal functionalization of arenes. The development of divergent nitrile-directed C-H functionalization (acetoxylation, pivalation, and methoxylation) offers an effective approach to rapidly increase synthetic complexity. Finally, the development of a mild reductive decyanation allows a traceless method to access functionalized biaryl motifs.

Prevention of Marine Biofouling Using the Natural Allelopathic Compound Batatasin-III and Synthetic Analogues

The current study reports the first comprehensive evaluation of a class of allelopathic terrestrial natural products as antifoulants in a marine setting. To investigate the antifouling potential of the natural dihydrostilbene scaffold, a library of 22 syn

Homo- and hetero-oxidative coupling of benzyl anions

The regioselective benzylic metalation of substituted toluenes using BuLi/KO-t-Bu/TMP(H) (LiNK metalation conditions) with subsequent in situ oxidative C-C coupling has been developed for the facile generation of 1,2-diarylethanes. A range of oxidants can be used for the oxidative coupling step, with 1,2-dibromoethane proving optimal. Heterocouplings can be achieved starting from a mixture of two different toluenes with a bias toward cross coupling achievable by using a 2-fold excess of one toluene starting material. The utility of this approach is illustrated by the synthesis of several biologically active natural products. A distinct advantage is that the synthetic steps typically required to preactivate the coupling substrates are eliminated and no transition metal is required to facilitate the C-C bond formation.