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2,2-bis(4-fluorophenyl)propanoic acid is a synthetic organic compound with the molecular formula C15H12F2O2. It is a white crystalline solid that is soluble in organic solvents and has a molecular weight of 260.25 g/mol. 2,2-bis(4-fluorophenyl)propanoic acid is characterized by the presence of two 4-fluorophenyl groups attached to a central propane chain, which terminates in a carboxylic acid group. It is used as an intermediate in the synthesis of various pharmaceuticals and agrochemicals, particularly in the production of certain anti-inflammatory and analgesic drugs. The presence of fluorine atoms in the molecule can significantly influence its chemical and physical properties, such as reactivity, lipophilicity, and bioavailability, making it a valuable building block in the development of new therapeutic agents.

337-54-2

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337-54-2 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 337-54-2 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 3,3 and 7 respectively; the second part has 2 digits, 5 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 337-54:
(5*3)+(4*3)+(3*7)+(2*5)+(1*4)=62
62 % 10 = 2
So 337-54-2 is a valid CAS Registry Number.

337-54-2Downstream Products

337-54-2Relevant academic research and scientific papers

Ligand-Accelerated Palladium(II)-Catalyzed Enantioselective Amination of C(sp2)-H Bonds

Cheng, Xiu-Fen,Fei, Fan,Li, Yan,Hou, Yi-Ming,Zhou, Xin,Wang, Xi-Sheng

supporting information, p. 6394 - 6398 (2020/08/24)

The first example of the Pd(II)-catalyzed enantioselective amination of aryl C-H bonds is reported. The key to the successful realization of this asymmetric catalytic transformation was the identification of mono-N-protected α-amino-O-methylhydroxamic acid (MPAHA) ligands, which promote reactivity under mild conditions and control enantioselectivity. The counteranions in the solvent medium, hexafluoroacetylacetate and acetate, were also found to play key roles in stereocontrol and reactivity enhancement.

Site-Selective Catalytic Carboxylation of Unsaturated Hydrocarbons with CO2 and Water

Gaydou, Morgane,Moragas, Toni,Juliá-Hernández, Francisco,Martin, Ruben

supporting information, p. 12161 - 12164 (2017/09/12)

A catalytic protocol that reliably predicts and controls the site-selective incorporation of CO2 to a wide range of unsaturated hydrocarbons utilizing water as formal hydride source is described. This platform unlocks an opportunity to catalytically repurpose three abundant, orthogonal feedstocks under mild conditions.

CARBOXYLATION OF ALCOHOLS WITH CARBON MONOXIDE SUPERSATURATED IN STRONG ACID. FACILE SYNTHESIS OF 2,2-BIS(4-HALOPHENYL)ACETIC, -PROPIONIC, AND RELATED ACIDS

Takahashi, Yukio,Yoneda, Norihiko,Nagai, Hiroshi

, p. 1733 - 1734 (2007/10/02)

Using 97percent H2SO4 supersaturated with carbon monoxide, bis(4-halophenyl)methanols, 1,1-bis(4-halophenyl)ethanols and related alcohols were transformed to the carboxylic acids in 60-95percent yields.

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