33798-39-9Relevant academic research and scientific papers
In situ hydrogen from aqueous-methanol for nitroarene reduction and imine formation over an Au-Pd/Al2O3 catalyst
Xiang, Yizhi,Meng, Qiangqiang,Li, Xiaonian,Wang, Jianguo
, p. 5918 - 5920 (2010)
In situ hydrogen from aqueous-methanol, instead of H2 or CO, was used to synthesize imines with a high selectivity from nitroarenes and carbonyl compounds over an Au-Pd/Al2O3 catalyst.
Silylative Reductive Amination of α,β-Unsaturated Aldehydes: A Convenient Synthetic Route to β-Silylated Secondary Amines
Kim, Eunae,Park, Sehoon,Chang, Sukbok
supporting information, p. 5765 - 5769 (2018/03/28)
Described here is a reductive amination/hydrosilylation cascade of α,β-unsaturated aldehydes mediated by a Lewis acidic borane catalyst. The present reaction system provides an one-pot synthetic route towards β-silylated secondary amines that have not been accessible by other previous catalysis. Comparative 1H NMR studies on the silylative reduction of enimines revealed that steric bulkiness of primary amine reactants strongly affects both catalytic efficiency and regioselectivity. This strategy was applicable to a broad range of substrates and amenable to one-pot gram-scale synthesis. Moreover, a diastereoselective introduction of the β-silyl group was also found to be feasible (d.r. up to 71:29).
