33810-04-7

Upstream product

• 123-11-5 4-methoxy-benzaldehyde 
• 78-84-2 isobutyraldehyde 
• 104736-12-1 2-Methyl-1-tributylstannanyl-propan-1-one 
• 100-07-2 4-methoxy-benzoyl chloride 
• 82938-20-3 3-methyl-1-(4-methoxyphenyl)-1-butanone 

Downstream Products

• 1421479-11-9 4-isopropyl-3-(4-methoxyphenyl)-1,2,5-thiadiazole-1,1-dioxide 
• 1421479-21-1 (S)-4-isopropyl-3-(4-methoxyphenyl)-4,5-dihydro-1,2,5-thiadiazoline-1,1-dioxide 
• 1421479-29-9 (3R,4S)-4-isopropyl-3-(4-methoxyphenyl)-1,2,5-thiadiazolidine-1,1-dioxide 
• 1421479-35-7 (3S,4S)-4-isopropyl-3-(4-methoxyphenyl)-1,2,5-thiadiazolidine-1,1-dioxide 
• 1421479-37-9 (1R,2S)-1-(4-methoxyphenyl)-3-methylbutane-1,2-diamine 
• 1421479-38-0 (1S,2S)-1-(4-methoxyphenyl)-3-methylbutane-1,2-diamine 
• 1421479-39-1 N,N'-[(1R,2S)-1-(4-methoxyphenyl)-3-methylbutane-1,2-diyl]bis(trifluoroacetamide) 
• 1421479-40-4 N,N'-[(1S,2S)-1-(4-methoxyphenyl)-3-methylbutane-1,2-diyl]bis(trifluoroacetamide) 

Relevant academic research and scientific papers

Enantioselective synthesis of 3,4-disubstituted cis- and trans-1,2,5-thiadiazolidine-1,1-dioxides as precursors for chiral 1,2-diamines

Both, cis- and trans-3,4-disubstituted thiadiazolidines 5 and 6 can enantioselectively be obtained from thiadiazoles 2 which, in turn, are efficiently prepared from the respective 1,2-diketone by an improved protocol. An asymmetric ruthenium-catalyzed transfer hydrogenation followed by a diastereoselective hydride addition furnishes exclusively the cis-isomers 5 which, under acidic conditions, undergo a novel isomerization into the trans-isomers 6. These cyclic sulfamides can be transformed into 1,2-diamines as well as 2,3-diamino acids.

A VERSATILE ACCESS TO UNSYMMETRICAL AND SYMMETRICAL α-DIKETONES VIA ORGANOTIN REAGENTS

Unsymmetrical α-diketones have been obtained via cross coupling of acyltins with acyl halides under PdCl2(PPh3)2 catalysis while symmetrical α-diketones have been readily obtained via "in situ" formation of acyltins using hexabutylditin and acyl chlorides under similar experimental conditions.