82938-20-3

Basic information

• Product Name: 1-(4-METHOXYPHENYL)-3-METHYLBUTAN-1-ONE
• Synonyms: 1-(4-METHOXYPHENYL)-3-METHYLBUTAN-1-ONE;1-(4-METHOXYPHENYL)-3-METHYLBUTAN-1-ONE(WXG01592)
• CAS NO: 82938-20-3
• Molecular Formula: C₁₂H₁₆O₂
• Molecular Weight: 192.25
• Mol File: 82938-20-3.mol
• Article Data: 16

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-(4-METHOXYPHENYL)-3-METHYLBUTAN-1-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-METHOXYPHENYL)-3-METHYLBUTAN-1-ONE(82938-20-3)
• EPA Substance Registry System: 1-(4-METHOXYPHENYL)-3-METHYLBUTAN-1-ONE(82938-20-3)

Safety Data

• Hazardous Substances Data: 82938-20-3(Hazardous Substances Data)

Usage

General Description

1-(4-Methoxyphenyl)-3-methylbutan-1-one, also known as p-Methoxy-α-methylcinnamaldehyde, is a chemical compound with the molecular formula C12H16O2. It is a yellow liquid with a floral, spicy odor. This chemical is commonly used in the fragrance and flavor industry as a scent enhancer and fixative. It is also used in the production of cosmetic and personal care products, as well as in the synthesis of other organic compounds. This chemical has potential applications in pharmaceuticals and agrochemicals, and it is important to handle and store it properly due to its flammability and skin and eye irritant properties.

Upstream product

• 503-74-2 3-methylbutyric acid 
• 100-66-3 methoxybenzene 
• 1468-39-9 Isovaleric anhydride 
• 108-12-3 isopentanoyl chloride 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 590-86-3 isovaleraldehyde 
• 5674-02-2 2-methylpropylmagnesium chloride 
• 874-90-8 4-methoxybenzonitrile 
• 5720-07-0 4-methoxyphenylboronic acid 
• 3319-15-1 rac-1-(4-methoxyphenyl)-ethanol 
• 67-63-0 isopropyl alcohol 
• 108-64-5 Ethyl isovalerate 
• 123-11-5 4-methoxy-benzaldehyde 
• 100757-90-2 1-(p-methoxyphenyl)-3-methyl-1-butanol 

Downstream Products

• 82938-21-4 Cyano-2-(p-methoxyphenyl)-4-methyl-pent-1-ene 
• 100757-90-2 1-(p-methoxyphenyl)-3-methyl-1-butanol 
• 1381862-15-2 (S)-2-isopropyl-1-(4-methoxyphenyl)pent-4-en-1-one 
• 1381862-29-8 C₁₄H₁₈O₃ 
• 1381862-22-1 C₁₆H₂₀O₄ 

Relevant articles and documents

Discovery of Novel 3-Amino-4-alkoxyphenylketones as PDE4 Inhibitors with Improved Oral Bioavailability and Safety against Spatial Memory Impairments

To realize PDE4 inhibitors with good developmental potentiality for the treatment of dementia, structure-based optimizations of lead compound FCPR03 resulted in novel aminophenylketones 9c and 9H with low nanomolar potency, which displayed comparable acti

Aminophenone compounds as well as preparation method and application thereof

The invention belongs to the technical field of medicinal chemistry, and particularly relates to aminophenone compounds as well as a preparation method and application thereof. The aminophenone compounds provided by the invention have a good inhibition effect on PDE4, also have good bioavailability, can be applied to preparation of drugs for treating PDE4-related diseases, and increase the optionsof drugs for treating PDE4-related diseases; and the effect of a part of the aminophenone compounds is equivalent to the effect of positive drugs, and the aminophenone compounds have good developmentpotential.

DABCO-promoted photocatalytic C-H functionalization of aldehydes

Herein we present a direct application of DABCO, an inexpensive and broadly accessible organic base, as a hydrogen atom transfer (HAT) abstractor in a photocatalytic strategy for aldehyde C-H activation. The acyl radicals generated in this step were arylated with aryl bromides through a well stablished nickel cross-coupling methodology, leading to a variety of interesting aryl ketones in good yields. We also performed computational calculations to shine light in the HAT step energetics and determined an optimized geometry for the transition state, showing that the hydrogen atom transfer between aldehydes and DABCO is a mildly endergonic, yet sufficiently fast step. The same calculations were performed with quinuclidine, for comparison of both catalysts and the differences are discussed.